| 1. |
- Aad, G., et al.
(författare)
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The ATLAS Experiment at the CERN Large Hadron Collider
- 2008
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 3:S08003
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Forskningsöversikt (refereegranskat)abstract
- The ATLAS detector as installed in its experimental cavern at point 1 at CERN is described in this paper. A brief overview of the expected performance of the detector when the Large Hadron Collider begins operation is also presented.
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| 2. |
- Bhardwaj, R. D., et al.
(författare)
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Neocortical neurogenesis in humans is restricted to development.
- 2006
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 103:33, s. 12564-8
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Tidskriftsartikel (refereegranskat)abstract
- Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of (14)C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally.
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| 3. |
- Curtis, Maurice A, et al.
(författare)
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Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension.
- 2007
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 315:5816, s. 1243-9
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Tidskriftsartikel (refereegranskat)abstract
- The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.
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| 4. |
- Eriksson, Henrik, et al.
(författare)
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Exact expectations for random graphs and assignments
- 2003
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Ingår i: Combinatorics, probability & computing. - 0963-5483 .- 1469-2163. ; 12, s. 401-412
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Tidskriftsartikel (refereegranskat)abstract
- For a random graph on n vertices where the edges appear with individual rates, we give exact formulas for the expected time at which the number of components has gone down to k and the expected length of the corresponding minimal spanning forest.For a random bipartite graph we give a formula for the expected time at which a k-assignment appears. This result has a bearing on the random assignment problem.
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| 5. |
- Eriksson, Henrik, et al.
(författare)
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Expected inversion number after k adjacent transpositions
- 2000
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Ingår i: Formal Power Series and Algebraic Combinatorics. - 3540672478 ; , s. 677-685
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Konferensbidrag (refereegranskat)abstract
- We give expressions for the expected number of inversions after t random adjacent transpositions have been performed on the identity permutation in Sn+1 The problem is a simplification of a problem motivated by genome evolution. For a fixed t and for all n greater than or equal to t, the expected number of inversions after t random adjacent transpositions isE-nt = t - 2/n ((t)(2)) + Sigma(r=2)(t) (-1)(r)/n(r) [2(r)C(r)((t)(r+1)) + 4d(r) ((t)(r))]where d(2) = 0, d(3) = 1, d(4) = 9, d(5) = 69,... is a certain integer sequence. An important part of the our method is the use of a heat. conduction analogy of the random walks, which guarantees certain properties of the solution.
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| 6. |
- Eriksson, Henrik, et al.
(författare)
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Note on the lamp lighting problem
- 2001
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Ingår i: Advances in Applied Mathematics. - : Elsevier BV. - 0196-8858 .- 1090-2074. ; 27:03-feb, s. 357-366
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Tidskriftsartikel (refereegranskat)abstract
- We answer some questions concerning the so-called sigma -game of Sutner [Linear cellular automata and the Garden of Eden, Math. Intelligencer 11 (1989), 49-53]. It is played on a graph where each vertex has a lamp, the light of which is toggled by pressing any vertex with an edge directed to the lamp. For example, we show that every configuration of lamps can be lit if and only if the number of complete matchings in the graph is odd. In the special case of an orthogonal grid one gets a criterion for whether the number of monomer-dimer tilings of an m x n grid is odd or even.
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| 7. |
- Melke, Jonas, 1971, et al.
(författare)
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Serotonin transporter gene polymorphisms and platelet [3H] paroxetine binding in premenstrual dysphoria.
- 2003
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Ingår i: Psychoneuroendocrinology. - 0306-4530. ; 28:3, s. 446-58
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to investigate if women with premenstrual dysphoria differ from controls with respect to the number of platelet serotonin transporters, and with respect to three polymorphisms in the gene coding for the serotonin transporter: a 44 base pair insertion/deletion in the promoter region, a variable number of tandem repeats in the second intron, and a single nucleotide polymorphism in the 3' untranslated region. Also, the possible relationship between the three polymorphisms and platelet serotonin transporter density was analyzed. The density of platelet [(3)H]paroxetine binding sites was significantly lower in women with premenstrual dysphoria than in controls, but patients and controls did not differ with respect to allele or genotype frequency for any of the three polymorphisms examined. A significant association between the number of platelet serotonin transporters and the promoter polymorphism was observed, subjects being homozygous for the short (deletion) variant having higher platelet serotonin transporter density than subjects carrying the long (insertion) allele. The results support the assumption that serotonin-related psychiatric disorders-such as premenstrual dysphoria-may be associated with a reduction in platelet [(3)H]paroxetine binding, but argue against the notion that this reduction is due to certain variants of the serotonin transporter gene being more common in patients than in controls.
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| 8. |
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| 9. |
- Tornblom, M, et al.
(författare)
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Lead time associated with screening for prostate cancer
- 2004
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136. ; 108:1, s. 122-129
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Tidskriftsartikel (refereegranskat)abstract
- Screening serum levels of prostate-specific antigen (PSA) is now a major strategy for early detection of prostate cancer (PC). Quantification of the lead time thus obtained is important both for understanding the development of PC and for evaluating the advantages and disadvantages of widespread screening. In our study, 1,233 randomly selected men living in Stockholm in 1988 were invited to participate in an early detection (ED) program, in which suspicious findings provided by digital rectal examination (DRE), transrectal ultrasonography (TRUS) and/or a PSA value greater than or equal to10.0 ng/mL were followed up by biopsy. The cumulative incidence (Kaplan-Meier) of PC in the 946 participants (ED) during 12 years of follow-up was compared to that of an age-matched, randomly selected reference population (RP) of 657 men for whom PSA values (from frozen serum samples) could also be obtained. The PC incidence in men in the RP with PSA values >3.0 ng/mL reached the corresponding level for the ED group after 10.6 years (the "catch-up" point). After 12 years of follow-up, the estimated median lead time for men with PSA values in this interval was 4.5 years in the ED population, compared to 7.8 years in the RP. With 20 years of follow-up, the estimated median lead time of the RP was enhanced to 10.7 years. The lead time in connection with PC was influenced by the initial PSA level (although with large variations), length of follow-up and sensitivity of the ED procedure employed. The ED program described here was not associated with major overdetection.
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| 10. |
- Abrahamsson, Maria, et al.
(författare)
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A new strategy for the improvement of photophysical properties in ruthenium(II) polypyridyl complexes. Synthesis and photophysical and electrochemical characterization of six mononuclear ruthenium(II) bisterpyridine-type complexes
- 2005
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Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 44:9, s. 3215-3225
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis and characterization of six ruthenium(II) bistridentate polypyridyl complexes is described. These were designed on the basis of a new approach to increase the excited-state lifetime of ruthenium(II) bisterpyridine-type complexes. By the use of a bipyridylpyridyl methane ligand in place of terpyridine, the coordination environment of the metal ion becomes nearly octahedral and the rate of deactivation via ligand-field (i.e., metal-centered) states was reduced as shown by temperature-dependent emission lifetime studies. Still, the possibility to make quasi-linear donor-ruthenium-acceptor triads is maintained in the complexes. The most promising complex shows an excited-state lifet me of tau = 15 ns in alcohol solutions at room temperature, which should be compared to a lifetime of tau = 0.25 ns for [Ru(tpy)(2)](2+). The X-ray structure of the new complex indeed shows a more octahedral geometry than that of [Ru(tpy)(2)](2+). Most importantly, the high excited-state energy was retained, and thus, so was the potential high reactivity of the excited complex, which has not been the case with previously published strategies based on bistridentate complexes.
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