| 1. |
- Azevedo, M, et al.
(författare)
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Infection by Helicobacter pylori expressing the BabA adhesin is influenced by the secretor phenotype
- 2008
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Ingår i: Journal of Pathology. - : Wiley. - 0022-3417 .- 1096-9896. ; 215:3, s. 308-316
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Tidskriftsartikel (refereegranskat)abstract
- Helicobacter pylori (Hp) infects half the world's population and causes diverse gastric lesions, from gastritis to gastric cancer. Our aim was to evaluate the significance of secretor and Lewis status in infection and in vitro adherence by Hp expressing BabA adhesin. We enrolled 304 Hp-infected individuals from Northern Portugal. Gastric biopsies, blood and saliva were collected. Polymerase chain reaction (PCR) and immunofluorescence were used to detect BabA+ Hp in gastric biopsies. In vitro adherence by a BabA expressing Hp strain to gastric biopsies was performed. Secretor status was identified by Ulex, a lectin that recognizes secretor-dependent glycan structures in saliva and in gastric mucosa, and by Lewis(a/b) antibodies, and indirectly by identification of an inactivating mutation in the FUT2 gene (G428A). BabA status of infecting Hp was associated with CagA and VacAs1 (p < 0.05), intercellular localization of Hp (p < 0.01) and the presence of intestinal metaplasia (p < 0.05) and degenerative alterations (p < 0.005) in the biopsies. BabA was associated (p < 0.05) with Ulex staining of gastric biopsies and, although not significantly, to absence of homozygosity for FUT2 G428A inactivating polymorphism. In vitro Hp adherence was higher in cases wild-type or heterozygous for FUT2 G428A mutation (p < 0.0001), cases staining for Ulex (p < 0.0001) and a(-)b+ and a(-)b(-) secretor phenotypes (p < 0.001). In conclusion, BabA+ Hp infection/adhesion is secretor-dependent and associated with the severity of gastric lesions.
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| 2. |
- Barret, B., et al.
(författare)
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Intercomparisons of trace gases profiles from the Odin/SMR and Aura/MLS limb sounders
- 2006
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 111:D21
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the intercomparison of O(3), HNO(3), ClO, N(2)O and CO profiles measured by the two spaceborne microwave instruments MLS ( Microwave Limb Sounder) and SMR ( Submillimetre Radiometer) on board the Aura and Odin satellites, respectively. We compared version 1.5 level 2 data from MLS with level 2 data produced by the French data processor version 222 and 225 and by the Swedish data processor version 2.0 for several days in September 2004 and in March 2005. For the five gases studied, an overall good agreement is found between both instruments. Most of the observed discrepancies between SMR and MLS are consistent with results from other intercomparison studies involving MLS or SMR. O(3) profiles retrieved from the SMR 501.8 GHz band are noisier than MLS profiles but mean biases between both instruments do not exceed 10%. SMR HNO(3) profiles are biased low relative to MLS's by similar to 30% above the profile peak. In the lower stratosphere, MLS ClO profiles are biased low by up to 0.3 ppbv relative to coincident SMR profiles, except in the Southern Hemisphere polar vortex in the presence of chlorine activation. N(2)O profiles from both instruments are in very good agreement with mean biases not exceeding 15%. Finally, the intercomparison between SMR and MLS CO profiles has shown a good agreement from the middle stratosphere to the middle mesosphere in spite of strong oscillations in the MLS profiles. In the upper mesosphere, MLS CO concentrations are biased high relative to SMR while negative values in the MLS retrievals are responsible for a negative bias in the tropics around 30 hPa.
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| 3. |
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| 4. |
- Eriksson, LE, et al.
(författare)
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Health-related quality of life in homo- and bisexual men attending a sexually transmitted disease clinic in Sweden
- 2007
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Ingår i: International journal of STD & AIDS. - : SAGE Publications. - 0956-4624 .- 1758-1052. ; 18:3, s. 207-211
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Tidskriftsartikel (refereegranskat)abstract
- Men who have sex with men (MSM) have an increased risk of contracting sexually transmitted diseases (STDs) and HIV. Studies of their health-related quality of life (HRQL) are uncommon, though such studies may provide additional knowledge that is of interest in counselling and care. The HRQL in MSM attending a clinic for STD- and HIV testing in Stockholm, Sweden, was investigated in 1996 and 2004, measured by means of the Swedish Health-Related Quality of Life questionnaire. The results were compared with those for men from a general Swedish population sample and with HIV-infected men. The HIV-negative MSM had significantly worse emotional wellbeing, satisfaction with family life, relation to their partner and general health perception, and better physical HRQL compared with the general Swedish population. There were no differences in the emotional and family dimensions between HIV-infected and HIV-negative MSM, but the HIV-negative group scored at a higher level in respect of their physical and general health than the HIV-infected group. No apparent differences over time were seen in the HIV-negative group. This study shows that psychosocial HRQL is lower for MSM than for a general male population sample, which calls for increased attention in the care of MSM patients.
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| 5. |
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| 6. |
- Eriksson, S., et al.
(författare)
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Magnetic island formation between large-scale flow vortices at an undulating postnoon magnetopause for northward interplanetary magnetic field
- 2009
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114:2, s. A00C17-
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Tidskriftsartikel (refereegranskat)abstract
- Time History of Events and Macroscale Interactions during Substorms multispacecraft observations are presented for a similar to 2-h-long postnoon magnetopause event on 8 June 2007 that for the first time indicate that the trailing (sunward) edges of Kelvin-Helmholtz (KH) waves are commonly related to small-scale < 0.56 R-E magnetic islands or flux transfer events (FTE) during the growth phase of these surface waves. The FTEs typically show a characteristic bipolar B-N structure with enhanced total pressure at their center. Most of the small-scale FTEs are not related to any major plasma acceleration. TH-A observations of one small FTE at a transition from the low-latitude boundary layer (LLBL) into a magnetosheath plasma depletion layer were reconstructed using separate techniques that together confirm the presence of a magnetic island within the LLBL adjacent to the magnetopause. The island was associated with a small plasma vortex and both features appeared between two large-scale (similar to 1 R-E long and 2000 km wide) plasma vortices. We propose that the observed magnetic islands may have been generated from a time-varying reconnection process in a low ion plasma beta (beta(i) < 0.2) and low 8.3 degrees field shear environment at the sunward edge of the growing KH waves where the local magnetopause current sheet may be compressed by the converging flow of the large-scale plasma vortices as suggested by numerical simulations of the KH instability.
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| 7. |
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| 8. |
- Jégou, F., et al.
(författare)
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Validation of Odin/SMR limb observations of ozone, comparisons with OSIRIS, POAM III, ground-based and balloon-borne intruments
- 2008
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Ingår i: Atmospheric Chemistry and Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 8:13, s. 3385-3409
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Tidskriftsartikel (refereegranskat)abstract
- The Odin satellite carries two instruments capable of determining stratospheric ozone profiles by limb sounding: the Sub-Millimetre Radiometer (SMR) and the UV-visible spectrograph of the OSIRIS (Optical Spectrograph and InfraRed Imager System) instrument. A large number of ozone profiles measurements were performed during six years from November 2001 to present. This ozone dataset is here used to make quantitative comparisons with satellite measurements in order to assess the quality of the Odin/SMR ozone measurements. In a first step, we compare Swedish SMR retrievals version 2.1, French SMR ozone retrievals version 222 (both from the 501.8 GHz band), and the OSIRIS retrievals version 3.0, with the operational version 4.0 ozone product from POAM III (Polar Ozone Atmospheric Measurement). In a second step, we refine the Odin/SMR validation by comparisons with ground-based instruments and balloon-borne observations. We use observations carried out within the framework of the Network for Detection of Atmospheric Composition Change (NDACC) and balloon flight missions conducted by the Canadian Space Agency (CSA), the Laboratoire de Physique et de Chimie de l\'{}Environnement (LPCE, Orléans, France), and the Service d'Aéronomie (SA, Paris, France). Coincidence criteria were 5° in latitude×10° in longitude, and 5 h in time in Odin/POAM III comparisons, 12 h in Odin/NDACC comparisons, and 72 h in Odin/balloons comparisons. An agreement is found with the POAM III experiment (10–60 km) within −0.3±0.2 ppmv (bias±standard deviation) for SMR (v222, v2.1) and within −0.5±0.2 ppmv for OSIRIS (v3.0). Odin ozone mixing ratio products are systematically slightly lower than the POAM III data and show an ozone maximum lower by 1–5 km in altitude. The comparisons with the NDACC data (10–34 km for ozonesonde, 10–50 km for lidar, 10–60 for microwave instruments) yield a good agreement within −0.15±0.3 ppmv for the SMR data and −0.3±0.3 ppmv for the OSIRIS data. Finally the comparisons with instruments on large balloons (10–31 km) show a good agreement, within −0.7±1 ppmv. The official SMR v2.1 dataset is consistent in all altitude ranges with POAM III, NDACC and large balloon-borne instruments measurements. In the SMR v2.1 data, no different systematic error has been found in the 0–35km range in comparison with the 35–60 km range. The same feature has been highlighted in both hemispheres in SMR v2.1/POAM III intercomparisons, and no latitudinal dependence has been revealed in SMR v2.1/NDACC intercomparisons.
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| 9. |
- Lacour, S., et al.
(författare)
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The limb-darkened Arcturus : imaging with the IOTA/IONIC interferometer
- 2008
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 485:2, s. 561-570
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We undertook an H band interferometric examination of Arcturus, a star frequently used as a spatial and spectral calibrator. Methods. Using the IOTA 3 telescope interferometer, we performed spectro-interferometric observations (R approximate to 35) of Arcturus. Atmospheric models and prescriptions were fitted to the data to derive the brightness distribution of the photosphere. Image reconstruction was performed using two software algorithms: WISARD and MIRA. Results. An achromatic power law proved to be a good model of the brightness distribution, with a limb darkening compatible with the one derived from atmospheric model simulations using our mARCS model. A Rosseland diameter of 21.05 +/- 0.21 was derived, corresponding to an effective temperature of T-eff = 4295 +/- 26 K. No companion was detected from the closure phases, with an upper limit on the brightness ratio of 8 x 10(-4) at 1 AU. The dynamic range at such distance from the photosphere was established as 1.5 x 10(-4) (1 sigma rms). An upper limit of 1.7 x 10(-3) was also derived for the level of brightness asymmetries present in the photosphere.
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| 10. |
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