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- Steen, Stig, et al.
(författare)
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Transplantation of lungs from a non-heart-beating donor
- 2001
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Ingår i: The Lancet. - 1474-547X. ; 357:9259, s. 825-829
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In animals, we have previously done successful lung transplantations using organs from non-heart-beating donors. We have also developed an ex-vivo system of assessing the function of such organs before transplantation. The next stage was to try the technique in human beings. Bearing in mind the sensitive ethical issues involved, our first aim was to find out what procedures would be acceptable, and to use the results to guide a clinical lung transplantation from a non-heart-beating donor. METHODS: The ethical acceptability of the study was gauged from the results of a broad information programme directed at the general public in Sweden, and from discussions with professionals including doctors, nurses, hospital chaplains, and judges. The donor was a patient dying of acute myocardial infarction in a cardiac intensive-care unit after failed cardiopulmonary resuscitation. The next of kin gave permission to cool the lungs within the intact body, and intrapleural cooling was started 65 min after death. Blood samples were sent for virological testing and cross matching. The next of kin then had time to be alone with the deceased. After 3 h, the body was transported to the operating theatre and the heart-lung block removed. The lungs were assessed ex vivo, and the body was transported to the pathology department for necropsy. RESULTS: No contraindications to transplantation were found, and the right lung was transplanted successfully into a 54-year-old woman with chronic obstructive pulmonary disease. The donor lung showed excellent function only 5 min after reperfusion and ventilation, and during the first 5 months of follow-up, the function of the transplanted lung has been good. INTERPRETATION: About half the deaths in Sweden are caused by cardiac and cerebrovascular disease. This group could be a potential source of lung donors. When all hospitals and ambulance personnel in Sweden have received training in non-heart-beating lung donation, we hope that there will be enough donor lungs of good quality for all patients needing a lung transplant.
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| 2. |
- Andersson, Stefan, et al.
(författare)
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Rekommendationer : Nationellt format för publiceringsdatabaser
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Vid ett antal lärosäten i Sverige har lokala system för att redovisa det egna lärosätets vetenskapliga publicering (publiceringsdatabaser) redan tagits i drift eller håller på att utvecklas. Uppgifterna i dessa system ligger i de flesta fall till grund för den redovisning av vetenskaplig publicering som Utbildningsdepartementet numera efterfrågar. För detta ändamål, och för eventuellt andra jämförande studier, är det viktigt att data anges på ett enhetligt sätt. Detta är även förutsättningen för att ett informationsutbyte vid exempelvis en gemensam exponering av svensk vetenskaplig publicering skall kunna möjliggöras.Därför har representanter för en del av dessa lärosäten fått i uppdrag att inom delprojekt 1 (DP 1) inom Samordning av den svenska högskolans elektroniska publicering (SVEP) utarbeta ett förslag till gemensamma riktlinjer för dessa publiceringsdatabaser.Dessa riktlinjer syftar till att ange vilka uppgifter som minst ska vara med vid beskrivningen av en publikation samt till att få en enhetlig klassificering vad gäller publikationstyp och ämnesområde.Förslag till utökningar av minimiformatet ges också under de olika elementen i beskrivingsformatet. Dessa utökningar motsvarar i princip en fullständig beskrivningsnivå.
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| 3. |
- Andersson, Åke, et al.
(författare)
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The 100 MHz RF system for MAX-II and MAX-III
- 2002
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Ingår i: 8th European Particle Accelerator Conference. ; , s. 2118-2120
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Konferensbidrag (refereegranskat)abstract
- The MAX-II synchrotron radiation source has since 1997 been operated routinely with a double RF system, 500 MHz active plus 1.5 GHz passive. Four Landau cavities have successfully provided increased Touschek beam lifetime, and damping of coupled bunch mode instabilities. However, the delivered power from the present 500 MHz RF system will be marginal for the operation of the planned MAX-II SC wigglers, with 250 mA circulating beam current. It is shown that it is favourable to change to a 100 MHz system, with one 500 MHz Landau cavity, both considering power consumption, beam lifetime and beam stability. The new RF system and the cavities, that are being built at MAX-lab, are described. The same RF combination and type of cavities will be used at the VUV source MAX-III
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| 7. |
- Carlsson, A, et al.
(författare)
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Pseudomonas-induced lung damage in cystic fibrosis correlates to bactericidal-permeability increasing protein (BPI)-autoantibodies
- 2003
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Ingår i: Clinical and Experimental Rheumatology. - 1593-098X. ; 21:Suppl. 32, s. 95-100
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Tidskriftsartikel (refereegranskat)abstract
- Objective. Lung damage is the most common cause of death in cystic fibrosis (CF). It is induced by bacterial colonization and inflammatory activity perpetuates its course. Autoantibodies directed against BPI (bactericidal permeability increasing protein), called BPI-ANCA, have recently been associated with cystic fibrosis. Here we confirm this association and evaluate the relation between ANCA and total IgG level as they relate to bacterial colonization, pulmonary function, and musculoskeletal symptoms. Methods. BPI-ANCA, MPO-ANCA, and PR3-ANCA were measured with ELISA in 46 adult patients with CF Total IgG was determined by immunoturbidimetry. Results were correlated to bacterial colonization, lung function and musculoskeletal symptoms. Results. BPI-ANCA was found in 33 patients. In the whole group, both BPI-ANCA and total IgG were inversely correlated to lung function, but in patients chronically colonized with Pseudomonas aeruginosa (P. aeruginosa), BPI-ANCA alone was correlated to lung damage (p = 0.01). Median lung function, measured as forced expiratory volume in I second, in P. aeruginosa colonized patients with high levels of BPI-ANCA was 43% of the predicted value. In BPI-ANCA negative, the corresponding figure was 83%. In patients not colonized with P. aeruginosa, this relation was less evident. No correlation between ANCA and musculoskeletal symptoms was seen. Conclusion. P. aeruginosa induced lung damage in CF patients is associated with the presence of BPI-ANCA. P. aeruginosa colonized patients without BPI-ANCA have almost normal lung function. We suggest that BPI-ANCA discriminate P. aeruginosa colonized CF patients with severe lung damage from those whose disease is less destructive. Vasculitis like symptoms in CF are not ANCA associated.
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| 9. |
- Durbeej, Bo, et al.
(författare)
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A density functional theory study of coniferyl alcohol intermonomeric cross linkages in lignin – three-dimensional structures, stabilities and the thermodynamic control hypothesis
- 2003
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Ingår i: Holzforschung. - : Walter de Gruyter. - 0018-3830 .- 1437-434X. ; 57:2, s. 150-164
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Tidskriftsartikel (refereegranskat)abstract
- Density functional theory methods are utilized to investigate structural features and stabilities of the most common lignin dimerization products. It is found that intra-molecular hydrogen bonding acts as a stabilizing force in the lowest-energy conformer(s) of several different dimeric lignin structures. Furthermore, the calculations show that the hypothesis of thermodynamic control of monolignol dimerization accounts for some of the results obtained in experimental studies aimed at determining the ratios of intermonomeric linkages. A quantitative correlation between experimentally observed ratios and calculated relative energies cannot, however, be pointed out.
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