| 1. |
- Uhlén, Mathias, et al.
(author)
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A human protein atlas for normal and cancer tissues based on antibody proteomics
- 2005
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In: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932
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Journal article (peer-reviewed)abstract
- Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
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| 2. |
- Abrahamsson, Marcus, et al.
(author)
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Analytical Input to Emergency Preparedness at the Municipal Level – a Case Study
- 2007
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In: Proceedings of Disaster Recovery and Relief: Current & Future Approaches (TIEMS 2007).
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Conference paper (peer-reviewed)abstract
- In this paper an approach for employing risk and vulnerability analyses as the basis for emergency preparedness planning is discussed and exemplified using a case study. The study consisted of three connected parts: a broad scope hazard identification and analysis, an assessment of potential assistance needs should any of the hazards materialise and finally a mapping of actors and dependencies. The case study was conducted as a series of workshops, involving key actors from the studied municipality. Some thirty hazard scenarios, originating from five different categories; accidents, epidemics, infrastructure/utilities breakdown/interruption, criminal activity and socially induced scenarios were identified, described and initially evaluated in terms of possible consequences over a range of predefined attributes. In the next step, an analysis of potential assistance needs that may evolve during the identified scenarios was undertaken. Furthermore, an effort was made to identify municipal actors of central importance in the management of potential emergency scenarios, their respective tasks, resources and dependence on service from various technical infrastructures, other actors etc. Examples from the resulting overview of potential emergency scenarios, generated assistance needs and emergency management actors, tasks, resources and dependencies are presented and discussed, alongside with some implications for societal preparedness activities.
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| 3. |
- Asplund, Marcus, et al.
(author)
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Price Discrimination in Oligopoly : evidence from regional newspapers
- 2008
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In: Journal of Industrial Economics. - : Wiley. - 0022-1821 .- 1467-6451. ; 56:2, s. 333-346
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Journal article (peer-reviewed)abstract
- Recent theoretical work has shown that the incentive to target rival firms' customers with low prices can increase price discrimination, and that the strength of the incentive depends on a firm's market position. Using data on Swedish newspaper subscriptions, we find strong support for these predictions. Newspapers with a local competitor sell a larger part of their circulation at a discount than monopoly newspapers. Moreover, in competitive markets, the use of discounts is inversely related to the newspaper's market share. We find no evidence that price discrimination based on observable and exogenous characteristics is influenced by the market structure.
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| 4. |
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| 5. |
- Asplund, Marcus, et al.
(author)
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Prices, margins and liquidity constraints : Swedish newspapers, 1990-1992
- 2005
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In: Economica. - : Wiley. - 0013-0427 .- 1468-0335. ; 72:286, s. 349-359
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Journal article (peer-reviewed)abstract
- A firm facing liquidity constraints in a recession may increase its price to exploit locked-in consumers in an attempt to boost short-run profits. We find support for such behaviour for Swedish regional newspapers during a deep recession. Newspapers sell both subscriptions and advertising space, and arguably buyers of the latter are less locked in. Newspapers with low solvency raised their subscription prices relative to others. In contrast, the changes in advertising price were independent of the newspapers' financial positions. Hence financial constraints affected firms' pricing behaviour only when consumers were locked in.
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| 6. |
- Bjorklund, Marcus Gry, et al.
(author)
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Microarray analysis using disiloxyl 70mer oligonucleotides
- 2008
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In: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 36:4, s. 1334-1342
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Journal article (peer-reviewed)abstract
- DNA microarray technology has evolved dramatically in recent years, and is now a common tool in researchers portfolios. The scope of the technique has expanded from small-scale studies to extensive studies such as classification of disease states. Technical knowledge regarding solid phase microarrays has also increased, and the results acquired today are more reliable than those obtained just a few years ago. Nevertheless, there are various aspects of microarray analysis that could be improved. In this article we show that the proportions of full-length probes used significantly affects the results of global analyses of transcriptomes. In particular, measurements of transcripts in low abundance are more sensitive to truncated probes, which generally increase the degree of cross hybridization and loss of specific signals. In order to improve microarray analysis, we here introduce a disiloxyl purification step, which ensures that all the probes on the microarray are at full length. We demonstrate that when the features on microarrays consist of full-length probes the signal intensity is significantly increased. The overall increase in intensity enables the hybridization stringency to be increased, and thus enhance the robustness of the results.
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| 7. |
- Björn, Eriksson, 1981-, et al.
(author)
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Energy saving system utilizing LQ-technique design
- 2009
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In: Proceedings of the Seventh International Conference on Fluid Power Transmission and Control. - Beijing : Beijing World Publishing Corporation. ; , s. 224-229
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Conference paper (peer-reviewed)abstract
- This paper deals with the control of individual metering systems. This paper deals with the control of an individual metering system that could be used for reducing metering losses by enabling recuperation and regeneration operation. A system that utilizes individual metering is more flexible than a conventional system since there are more control signals and thereby more outputs to control. Energy saving aspects is among the main reasons for the research on this kind of system, but there is also an opportunity of improvements of the dynamics compared to a conventional system. In this paper an approach with LQtechnique are presented for improvements of system dynamics. Since all states in the system can not be measured a state observer is also considered in the control design. These work present simulations, implementations in a real world forwarder application and results from verifying experiments.
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| 8. |
- Boström, Dan, 1954-, et al.
(author)
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Ash transformations in fluidized-bed combustion of rapeseed meal
- 2009
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In: Energy & Fuels. - : American Chemical Society (ACS). - 0887-0624 .- 1520-5029. ; 23:5, s. 2700-2706
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Journal article (peer-reviewed)abstract
- The global production of rapeoil is increasing. A byproduct is rapeseed meal that is a result of the oil extraction process. Presently the rapeseed meal mainly is utilized as animal feed. An interesting alternative use is, however, energy conversion by combustion. This study was undertaken to determine the combustion properties of rapeseed meal and bark mixtures in a bubbling fluidized bed, with emphasis on gas emissions, ash formation, -fractionation and -interaction with the bed material. Due to the high content of phosphorus in rapeseed meal the fuel ash is dominated by phosphates, in contrast to most woody biomass where the ash is dominated by silicates. From a fluidized bed combustion (FBC) point of view, rapeseed meal could be a suitable fuel. Considering FBC agglomeration effects, pure rapeseed meal is in level with the most suitable fuels, as earlier tested by the methods utilized in the present investigation. The SO2 emission, however, is higher than most woody biomass fuels as a direct consequence of the high levels of sulfur in the fuel. Also the particulate matter emission, both submicron and coarser particles, is higher. Again this can be attributed the high ash content of rapeseed meal. The high abundance of SO2 is apparently effective for sulfatization of KCl in the flue gas. Practically no KCl was observed in the particulate matter of the flue gas. A striking difference in the mechanisms of bed agglomeration for rapeseed meal compared to woody biomass fuels was also observed. The ubiquitous continuous layers on the bed grains found in FBC combustion of woody biomass fuels was not observed in the present investigation. Instead very thin and discontinuous layers were observed together with isolated partly melted bed ash particles. The latter could occasionally be seen as adhered to the quartz bed grains. Apparently the bed agglomeration mechanism, that obviously demanded rather high temperatures, involved more of adhesion by partly melted ash derived potassium-calcium phosphate bed ash particles/droplets than direct attack of gaseous alkali on the quartz bed grains forming potassium-calcium silicate rich bed grain layers. An explanation could be found in the considerable higher affinity for base cations of phosphorus than silicon. This will to a great extent withdraw the present basic oxides from attacking the quartz bed grains with agglomeration at low temperatures as a result.
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| 9. |
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| 10. |
- De Geyter, Sigrid, et al.
(author)
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Effects of non-quartz minerals in natural bed sand on agglomeration characteristics during fluidized bed combustion of biomass fuels
- 2007
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In: Energy & Fuels. - : American Chemical Society (ACS). - 0887-0624 .- 1520-5029. ; 21:5, s. 2663-2668
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Journal article (peer-reviewed)abstract
- Most of the previous literature on fluidized bed agglomeration during biomass combustion is based on quartz as a bed material. Full-scale installations however often use natural sand, which apart from quartz may contain a high fraction of non-quartz minerals such as potassium feldspar and plagioclase. The objective of the present study was therefore to elucidate the effects of non-quartz minerals occurring in natural sand on the agglomeration behavior during fluidized bed combustion of biomass fuels. Three fuels typical for previously determined agglomeration mechanisms were chosen as model fuels: calcium-rich bark, potassium-rich olive residues, and silica- and potassium-rich wheat straw. Two different feldspar minerals were used: a potassium feldspar and a plagioclase, labradorite, which both occur in many commercial bed materials. Furthermore, olivine was used as a bed material as this mineral represents another type of bed material used in some full-scale installations. Quartz was used as a reference bed material. The effects of non-quartz minerals in natural sand on initial defluidization temperature were assessed during carefully controlled, bench-scale fluidized bed agglomeration experiments. Bed material samples and agglomerates were analyzed using scanning electron microscopy/energy-dispersive spectroscopy (SEM/EDS) in order to explore the occurrence and chemical composition of coating and attack layers on the bed particles and necks between agglomerated particles. Significant differences in agglomeration characteristics were found for the different minerals when bark and olive residue were combusted. Potassium-feldspar was shown to lower the initial defluidization temperature for combustion of bark and olive residues. Plagioclase and olivine on the other hand were found to increase the initial defluidization temperature as compared to quartz for the combustion of olive residue, but for bark combustion, they did not differ significantly from quartz. During combustion of wheat straw, all bed materials agglomerated shortly after the startup of the experiment. For bark and olive residue samples, attack layers were found on all bed materials and the composition of the inner attack layer and agglomerate necks differed significantly with the fuel/bed material combination. For wheat straw however, no continuous attack layers were found, and the bed material composition was concluded not to influence the agglomeration characteristics for this biomass. The results were used to suggest possible mechanisms involved in layer formation for the different minerals.
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