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- Abrahamsson, Kate, 1959, et al.
(författare)
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Pivalic acid-induced carnitine deficiency and physical exercise in humans.
- 1996
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Ingår i: Metabolism: clinical and experimental. - : Elsevier BV. - 0026-0495. ; 45:12, s. 1501-7
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Tidskriftsartikel (refereegranskat)abstract
- To study the effect of carnitine depletion on physical working capacity, healthy subjects were administered pivaloyl-conjugated antibiotics for 54 days. The mean carnitine concentration in serum decreased from 35.0 to 3.5 mmicromol/L, and in muscle from 10 to 4.3 micromol/g noncollagen protein (NCP). Exercise tests were performed before and after 54 days' administration of the drug. At submaximal exercise, there was a slight increase in the concentration of 3-hydroxybutyrate in serum, presumably caused by decreased fatty acid oxidation in the liver. There was also a decreased consumption of muscle glycogen, indicating decreased glycolysis in the skeletal muscle. The muscle presumably had enough energy available, since there was no significant decrease in the concentration of adenosine triphosphate (ATP) and creatine phosphate during exercise. The work at maximal oxygen uptake (VO2max) and the maximal heart rate were reduced. Since VO2max is considered dependent on heart function, carnitine depletion seemed to affect cardiac function.
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- Abrahamsson, Kate, 1959, et al.
(författare)
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Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid.
- 1995
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Ingår i: British heart journal. - : BMJ. - 0007-0769. ; 74:6, s. 656-9
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Tidskriftsartikel (refereegranskat)abstract
- To study the effect of induced carnitine depletion on myocardial structure and function.7 healthy adult volunteers given 1200 mg pivmecillinam per day for 7-8 weeks were studied by echocardiography before and after 7-8 weeks of treatment and a 15 months follow up after the treatment period.Teaching hospital.Carnitine concentration in serum, urine, and muscle and echocardiographic measurements.After 7-8 weeks of treatment the median free serum carnitine concentration was reduced to 7% and the median total muscle carnitine concentration to 46% of the pretreatment levels. The median diastolic interventricular septum thickness decreased by 14% (mean 26%, P = 0.028) and the median left ventricular mass by 10% (mean 20%, P = 0.018). Fifteen months later these dimensions had increased but not completely returned to pretreatment values.Extended treatment with pivalic acid containing antibiotics causes carnitine depletion which may lead to changes in cardiac structure.
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- Ahuja, R, et al.
(författare)
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Calculated electronic and optical properties of a graphite intercalation compound: LiC6
- 1997
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Ingår i: JOURNAL OF PHYSICS-CONDENSED MATTER. - : IOP PUBLISHING LTD. - 0953-8984. ; 9:45, s. 9845-9852
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We have used the linear muffin-tin orbital method, without geometrical approximations, to calculate the electronic structure of LiC6. Using our self-consistent solution, we have calculated the anisotropic frequency-dependent dielectric function and the re
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- Ahuja, R, et al.
(författare)
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Calculated optical properties of a solar energy material: CuGaS2
- 1998
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Ingår i: SOLAR ENERGY MATERIALS AND SOLAR CELLS. - : ELSEVIER SCIENCE BV. - 0927-0248. ; 53:3-4, s. 357-366
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The full-potential linear muffin-tin orbital method is used to study the electronic structure of the solar energy material CuGaS2. From this the optical reflectivity is calculated and compared with experiment, both for the case when the polarization vecto
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- Ahuja, R, et al.
(författare)
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Electronic and optical properties of InP
- 1997
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Ingår i: SOLID STATE COMMUNICATIONS. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0038-1098. ; 104:5, s. 249-252
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We have calculated the band structure and dielectric function of InP by means of an accurate first-principles method using the full potential linear muffin-tin orbital method (FPLMTO). Our calculated dielectric functions is compared with the recent data o
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- Ahuja, R, et al.
(författare)
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Electronic and optical properties of red HgI2
- 1996
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Ingår i: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMER INST PHYSICS. - 0163-1829. ; 54:15, s. 10419-10424
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Within the local-density approximation we have used the linear muffin-tin orbital method, without geometrical approximations, to calculate the electronic structure of red HgI2. Using the self-consistent potential we have calculated the energy bands and fr
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