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- Eriksson, M, et al.
(författare)
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Angiotensin converting enzyme dependent and non-dependent effects of a fibrinogen-derived pentapeptide on microvascular permeability in rat skin.
- 1983
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Ingår i: Upsala Journal of Medical Sciences. - 0300-9734 .- 2000-1967. ; 88:2, s. 95-101
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Tidskriftsartikel (refereegranskat)abstract
- A permeability-increasing pentapeptide, termed peptide 6A, derived from plasmin-degraded human fibrinogen and known to potentiate the increase in microvascular permeability caused by bradykinin was investigated concerning its angiotensin converting enzyme (A.C.E.) related effects. When applied to a rat skin model together with a specific inhibitor of this enzyme, peptide 6A showed a potentiated effect after 30 min. but not after 5 min. The same was also true for bradykinin. These findings suggest that the degradation rate of these peptides is decreased with resulting prolongation of the period of leakage, when the action of A.C.E. is opposed. It is deduced that peptide 6A may act as a partial antagonist of this enzyme in the rat skin model. Addition of peptide 6A to a mixture of bradykinin together with inhibitors of the enzymes degrading bradykinin before application to the rat skin, significantly augmented the extravasation of 125I-albumin. These findings are consistent with data indicating that peptide 6A is a prostacyclin-releaser able to induce vasodilation. This effect of peptide 6A on the microcirculation seems to be separate from its angiotensin converting enzyme-related effects.
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| 2. |
- Eriksson, M, et al.
(författare)
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Enhancement of the permeability-increasing effect of bradykinin and substance P by a peptide derived from fibrinogen.
- 1983
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Ingår i: International journal of microcirculation, clinical and experimental. - 0167-6865. ; 2:1, s. 53-9
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Tidskriftsartikel (refereegranskat)abstract
- Two low molecular weight fibrin(ogen) degradation products, 6A (Ala-Arg-Pro-Ala-Lys) and 6D (Ser-Gln-Leu-Gln-Lys-Val-Pro-Pro-Glu-Trp-Lys) that are known to increase vascular permeability were injected together with bradykinin, substance P, neurotensin, histamine or tuftsin into the dorsal skin of rats. Effects on microvascular permeability were evaluated as leakage of intravenously injected 125I-labelled human serum albumin to tissues. It was found that peptide 6A potentiated the leakage caused by bradykinin and also, to a minor extent, that caused by substance P over a 30 min period, but not of any other substance. Peptide 6D increased bradykinin-induced leakage to a lower degree than did peptide 6A. Thus, it is shown that products resulting from fibrinolysis exert a selective effect upon the action of bradykinin and of substance P.
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| 3. |
- Eriksson, M., et al.
(författare)
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Soft-tissue sarcomas and exposure to chemical substances : A case-referent study
- 1981
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Ingår i: British Journal of Industrial Medicine. - : BMJ. - 0007-1072. ; 38:1, s. 27-33
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Tidskriftsartikel (refereegranskat)abstract
- In 1977 several patients were seen with soft-tissue sarcomas and previous exposure to phenoxy acids. This clinical observation resulted in a case-referent (case-control) study being undertaken which showed that exposure to phenoxy acids or chlorophenols, which are chemically related, gave a roughly six-fold increase in the risk for this type of tumor. A further case-referent study of soft-tissue sarcomas has now been performed to confirm these earlier findings and also to obtain further information on the effects of different phenoxy acids. This new investigation gave an increase of the same magnitude in the risk for soft-tissue sarcomas after exposure to phenoxy acids or chlorophenols, but this risk related also to exposure to phenoxy acids free from impurities, such as polychlorinated dibenzodioxins and dibenzofurans.
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| 4. |
- Eriksson, T., et al.
(författare)
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Successive Encoding of Correlated Sources
- 1982
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The encoding of a discrete memoryless multiple source for reconstruction of a sequence with is considered. We require that the encoding should be such that is encoded first without any consideration of , while in a seeond part of the encoding this latter sequence is encoded based on knowledge of the outcome of the first encoding. The resulting scheme is called successive encoding. We find general outer and inner bounds for the corresponding set of achievable rates along with a complete single letter characterization for the special case . Comparisons with the Slepian-Wolf problem [3] and the Ahlswede-Körner-Wyner side information problem [2 ], [9) are carried out.
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