| 1. |
- Espinosa-Oliva, Ana M., et al.
(författare)
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Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain
- 2024
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Ingår i: Neuropathology and Applied Neurobiology. - 0305-1846. ; 50:1
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Tidskriftsartikel (refereegranskat)abstract
- Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. Methods: We have analysed the gut and the ventral midbrain from subjects previously diagnosed with IBD and form a DSS-based rat model of gut inflammation in terms of α-syn pathology. Results: Our data support the existence of pathogenic α-syn in both the gut and the brain, thus reinforcing the potential role of the ENS as a contributing factor in PD aetiology. Additionally, we have analysed the effect of a DSS-based rat model of gut inflammation to demonstrate (i) the appearance of P-α-syn inclusions in both Auerbach's and Meissner's plexuses (gut), (ii) an increase in α-syn expression in the ventral mesencephalon (brain) and (iii) the degeneration of nigral dopaminergic neurons, which all are considered classical hallmarks in PD. Conclusion: These results strongly support the plausibility of Braak's hypothesis and emphasise the significance of peripheral inflammation and the gut-brain axis in initiating α-syn aggregation and transport to the substantia nigra, resulting in neurodegeneration.
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| 2. |
- Pick, Cari M., et al.
(författare)
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Fundamental social motives measured across forty-two cultures in two waves
- 2022
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Ingår i: Scientific Data. - : Springer Nature. - 2052-4463. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- How does psychology vary across human societies? The fundamental social motives framework adopts an evolutionary approach to capture the broad range of human social goals within a taxonomy of ancestrally recurring threats and opportunities. These motives-self-protection, disease avoidance, affiliation, status, mate acquisition, mate retention, and kin care-are high in fitness relevance and everyday salience, yet understudied cross-culturally. Here, we gathered data on these motives in 42 countries (N = 15,915) in two cross-sectional waves, including 19 countries (N = 10,907) for which data were gathered in both waves. Wave 1 was collected from mid-2016 through late 2019 (32 countries, N = 8,998; 3,302 male, 5,585 female; M-age = 24.43, SD = 7.91). Wave 2 was collected from April through November 2020, during the COVID-19 pandemic (29 countries, N = 6,917; 2,249 male, 4,218 female; M-age = 28.59, SD = 11.31). These data can be used to assess differences and similarities in people's fundamental social motives both across and within cultures, at different time points, and in relation to other commonly studied cultural indicators and outcomes.
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| 3. |
- Tsopra, Rosy, et al.
(författare)
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Reorganisation of GP surgeries during the COVID-19 outbreak : analysis of guidelines from 15 countries
- 2021
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Ingår i: BMC Family Practice. - : BioMed Central. - 1471-2296. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- Background General practitioners (GPs) play a key role in managing the COVID-19 outbreak. However, they may encounter difficulties adapting their practices to the pandemic. We provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the pandemic from 15 countries. Methods A network of GPs collaborated together in a three-step process: (i) identification of key recommendations of GP surgery reorganisation, according to WHO, CDC and health professional resources from health care facilities; (ii) collection of key recommendations included in the guidelines published in 15 countries; (iii) analysis, comparison and synthesis of the results. Results Recommendations for the reorganisation of GP surgeries of four types were identified: (i) reorganisation of GP consultations (cancelation of non-urgent consultations, follow-up via e-consultations), (ii) reorganisation of GP surgeries (area partitioning, visual alerts and signs, strict hygiene measures), (iii) reorganisation of medical examinations by GPs (equipment, hygiene, partial clinical examinations, patient education), (iv) reorganisation of GP staff (equipment, management, meetings, collaboration with the local community). Conclusions We provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the COVID-19 outbreak from 15 countries. These guidelines focus principally on clinical care, with less attention paid to staff management, and the area of epidemiological surveillance and research is largely neglected. The differences of guidelines between countries and the difficulty to apply them in routine care, highlight the need of advanced research in primary care. Thereby, primary care would be able to provide recommendations adapted to the real-world settings and with stronger evidence, which is especially necessary during pandemics.
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| 4. |
- Galárraga-Espinosa, Daniela, et al.
(författare)
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Evolution of cosmic filaments in the MTNG simulation?
- 2024
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Ingår i: Astronomy and Astrophysics. - 0004-6361. ; 684
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of the evolution of cosmic filaments across redshift with an emphasis on some important properties: filament lengths, growth rates, and radial profiles of galaxy densities. Following an observation-driven approach, we built cosmic filament catalogues at z = 0, 1, 2, 3, and 4 from the galaxy distributions of the large hydro-dynamical run of the MilleniumTNG project. We employed the extensively used DisPerSE cosmic web finder code, for which we provide a user-friendly guide, including the details of a physics-driven calibration procedure, with the hope of helping future users. We performed the first statistical measurements of the evolution of connectivity in a large-scale simulation, finding that the connectivity of cosmic nodes (defined as the number of filaments attached) globally decreases from early to late times. The study of cosmic filaments in proper coordinates reveals that filaments grow in length and radial extent, as expected from large-scale structures in an expanding Universe. But the most interesting results arise once the Hubble flow is factored out. We find remarkably stable comoving filament length functions and over-density profiles, showing only little evolution of the total population of filaments in the past ∼12.25 Gyr. However, by tracking the spatial evolution of individual structures, we demonstrate that filaments of different lengths actually follow different evolutionary paths. While short filaments preferentially contract, long filaments expand along their longitudinal direction with growth rates that are the highest in the early, matter-dominated Universe. Filament diversity at a fixed redshift is also shown by the different (∼5σ) density values between the shortest and longest filaments. Our results hint that cosmic filaments can be used as additional probes for dark energy, but further theoretical work is still needed.
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| 5. |
- García-Revilla, Juan, et al.
(författare)
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Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
- 2022
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Ingår i: Cell Death and Disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 13:7
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Forskningsöversikt (refereegranskat)abstract
- The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes is the upregulation of galectin-3. Representative examples of these phenotypes include disease-associated microglia (DAM) and white-associated microglia (WAM), whose role(s) in neuroprotection/neurotoxicity is a matter of high interest in the microglia community. In this review, we summarise the main findings that demonstrate the ability of galectin-3 to interact with key pattern recognition receptors, including, among others, TLR4 and TREM2 and the importance of galectin-3 in the regulation of microglia activation. Finally, we discuss increasing evidence supporting the involvement of this lectin in the main neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, traumatic brain injury, and stroke.
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| 6. |
- Lalander, Rickard, et al.
(författare)
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Indigenous Gold Mining in the Kenkuim Shuar Community : A Decolonial and Postcapitalist Approach to Sustainability
- 2021
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Ingår i: Revista iberoamericana de estudios de desarrollo / Iberoamerican Journal of Development Studies. - Saragoza : Universidad de Zaragoza (Spain) ; Spanish Network of Development Studies (REEDES). - 2254-2035. ; 10:2, s. 178-202
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Tidskriftsartikel (refereegranskat)abstract
- This article analyzes the experiences of the small Shuar community of Kenkuim (Congüime) in the Ecuadorian Amazon that since 2016 carries out gold mining through the communitarian company Exploken Minera. The case is unique in South America, not only for being the only example of indigenous mining granted formal state concession, but also for its green profile, without the usage of chemicals or heavy metals. Within a setting of expanding extractivism conditioned by global capitalism and a theoretical framework of a decolonial and postcapitalist approach to sustainability, this ethnographic study deals with the expressions of resistance and adaptation of the Kenkuim community and how socio-cultural, ecological, and economic values are articulated by Shuar actors in relation to the new indigenous mining project. The results indicate that this mining experiment constitutes a meaningful alternative to destructive extractivismin line with decolonial and postcapitalist reasoning.
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| 7. |
- Lalander, Rickard, et al.
(författare)
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Una ecología política de minería indígena responsable : Dilemas, disputas y desafíos en la comunidad Shuar de Congüime de la Amazonía ecuatoriana
- 2020
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Ingår i: Revista Chilena de Derecho y Ciencia Política. - : Universidad Catolica de Temuco. - 0718-9389 .- 0719-2150. ; 11:1, s. 66-101
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Tidskriftsartikel (refereegranskat)abstract
- Desde 2016, la comunidad indígena Shuar de Congüime en la Amazonía ecuatoriana tiene la concesión para extraer oro en su territorio mediante su empresa comunitaria Exploken Minera. Con su misión de una minería socio-ecológicamente responsable, invirtiendo los ingresos en la comunidad y sin usar químicos o metales pesados, este modelo único se contrasta con la extracción minera transnacional e ilegal en territorios indígenas. Con inspiración teórica y metodológica de la ecología política, justicia ambiental y el post-desarrollo, así como la conceptualización de utopías reales, este estudio etnográfico trata de las experiencias de gobernanza y justicia socioambiental de la empresa comunitaria y los dilemas, disputas y desafíos que emergen en la comunidad con esta nueva situación. El resultado indica que varios desafíos estructurales siguen sin resolverse. Si bien las experiencias de responsabilidad socioecológica de Exploken constituyen una opción ante el extractivismo destructivo y considerando la mejora de las condiciones de vida de muchas familias Shuar, surgieron nuevas tensiones sociales en Congüime, incluso transformaciones de las estructuras de poder social.
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| 8. |
- Lembke, Magnus, 1964-, et al.
(författare)
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Indigenous Gold Mining in the Kenkuim Shuar Community : A Decolonial and Postcapitalist Approach to Sustainability
- 2021
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Ingår i: Revista iberoamericana de estudios de desarrollo / Iberoamerican Journal of Development Studies. - : Universidad de Zaragoza. - 2254-2035.
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Tidskriftsartikel (refereegranskat)abstract
- This article analyzes the experiences of the small Shuar community of Kenkuim (Congüime) in the Ecuadorian Amazon that since 2016 carries out gold mining through the communitarian company Exploken Minera. The case is unique in South America, not only for being the only example of indigenous mining granted formal state concession, but also for its green profile, without the usage of chemicals or heavy metals. Within a setting of expanding extractivism conditioned by global capitalism and a theoretical framework of a decolonial and postcapitalist approach to sustainability, this ethnographic study deals with the expressions of resistance and adaptation of the Kenkuim community and how socio-cultural, ecological, and economic values are articulated by Shuar actors in relation to the new indigenous mining project. The results indicate that this mining experiment constitutes a meaningful alternative to destructive extractivismin line with decolonial and postcapitalist reasoning.
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| 9. |
- Moreno-Espinosa, Ana L., et al.
(författare)
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Prediction of Neonatal Respiratory Morbidity Assessed by Quantitative Ultrasound Lung Texture Analysis in Twin Pregnancies
- 2022
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Ingår i: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 11:16
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to evaluate the performance of quantitative ultrasound of fetal lung texture analysis in predicting neonatal respiratory morbidity (NRM) in twin pregnancies. This was an ambispective study involving consecutive cases. Eligible cases included twin pregnancies between 27.0 and 38.6 weeks of gestation, for which an ultrasound image of the fetal thorax was obtained within 48 h of delivery. Images were analyzed using quantusFLM® version 3.0. The primary outcome of this study was neonatal respiratory morbidity, defined as the occurrence of either transient tachypnea of the newborn or respiratory distress syndrome. The performance of quantusFLM® in predicting NRM was analyzed by matching quantitative ultrasound analysis and clinical outcomes. This study included 166 images. Neonatal respiratory morbidity occurred in 12.7% of cases, and it was predicted by quantusFLM® analysis with an overall sensitivity of 42.9%, specificity of 95.9%, positive predictive value of 60%, and negative predictive value of 92.1%. The accuracy was 89.2%, with a positive likelihood ratio of 10.4, and a negative likelihood ratio of 0.6. The results of this study demonstrate the good prediction capability of NRM in twin pregnancies using a non-invasive lung texture analysis software. The test showed an overall good performance with high specificity, negative predictive value, and accuracy.
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| 10. |
- Rodríguez-Gómez, José A, et al.
(författare)
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Microglia : Agents of the CNS Pro-Inflammatory Response.
- 2020
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Ingår i: Cells. - : MDPI AG. - 2073-4409. ; 9:7
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Tidskriftsartikel (refereegranskat)abstract
- The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though the research of microglia spans over a century, the last two decades have increased our understanding exponentially. Here, we discuss the phenotypic transformation from homeostatic microglia towards reactive microglia, initiated by specific ligand binding to pattern recognition receptors including toll-like receptor-4 (TLR4) or triggering receptors expressed on myeloid cells-2 (TREM2), as well as pro-inflammatory signaling pathways triggered such as the caspase-mediated immune response. Additionally, new research disciplines such as epigenetics and immunometabolism have provided us with a more holistic view of how changes in DNA methylation, microRNAs, and the metabolome may influence the pro-inflammatory response. This review aimed to discuss our current knowledge of pro-inflammatory microglia from different angles, including recent research highlights such as the role of exosomes in spreading neuroinflammation and emerging techniques in microglia research including positron emission tomography (PET) scanning and the use of human microglia generated from induced pluripotent stem cells (iPSCs). Finally, we also discuss current thoughts on the impact of pro-inflammatory microglia in neurodegenerative diseases.
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