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- Kueppers, Michael, et al.
(författare)
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Triple F-a comet nucleus sample return mission
- 2009
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:3, s. 809-847
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Tidskriftsartikel (refereegranskat)abstract
- The Triple F (Fresh From the Fridge) mission, a Comet Nucleus Sample Return, has been proposed to ESA's Cosmic Vision program. A sample return from a comet enables us to reach the ultimate goal of cometary research. Since comets are the least processed bodies in the solar system, the proposal goes far beyond cometary science topics (like the explanation of cometary activity) and delivers invaluable information about the formation of the solar system and the interstellar molecular cloud from which it formed. The proposed mission would extract three sample cores of the upper 50 cm from three locations on a cometary nucleus and return them cooled to Earth for analysis in the laboratory. The simple mission concept with a touch-and-go sampling by a single spacecraft was proposed as an M-class mission in collaboration with the Russian space agency ROSCOSMOS.
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- Bilski, P., et al.
(författare)
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The problems associated with the monitoring of complex workplace radiation fields at European high-energy accelerators and thermonuclear fusion facilities
- 2007
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 0144-8420 .- 1742-3406. ; 126:1-4, s. 491-496
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Tidskriftsartikel (refereegranskat)abstract
- The European Commission is funding within its Sixth Framework Programme a three-year project (2005-2007) called CONRAD, COordinated Network for RAdiation Dosimetry. The organisational framework for this project is provided by the European Radiation Dosimetry Group EURADOS. One task within the CONRAD project, Work Package 6 (WP6), was to provide a report outlining research needs and research activities within Europe to develop new and improved methods and techniques for the characterisation of complex radiation fields at workplaces around high-energy accelerators, but also at the next generation of thermonuclear fusion facilities. The paper provides an overview of the report, which will be available as CERN Yellow Report.
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- Becherini, Yvonne, et al.
(författare)
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Time correlations of high energy muons in an underground detector
- 2005
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Ingår i: Astroparticle physics. - : Elsevier. - 0927-6505 .- 1873-2852. ; 23:3, s. 341-348
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Tidskriftsartikel (refereegranskat)abstract
- We present the result of a search for correlations in the arrival times of high energy muons collected from 1995 till 2000 with the streamer tube system of the complete MACRO detector at the underground Gran Sasso Lab. Large samples of single muons (8.6 million), double muons (0.46 million) and multiple muons with multiplicities from 3 to 6 (0.08 million) were selected. These samples were used to search for time correlations of cosmic ray particles coming from the whole upper hemisphere or from selected space cones. The results of our analyses confirm with high statistics a random arrival time distribution of high energy cosmic rays. (c) 2005 Elsevier B.V. All rights reserved.
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| 9. |
- Forte, A, et al.
(författare)
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c-Myc antisense oligonucleotides preserve smooth muscle differentiation and reduce negative remodelling following rat carotid arteriotomy
- 2005
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Ingår i: Journal of Vascular Research. - : S. Karger AG. - 1423-0135 .- 1018-1172. ; 42:3, s. 214-225
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The vascular biology of restenosis is complex and not fully understood, thus explaining the lack of effective therapy for its prevention in clinical settings. The role of c-Myc in arteriotomy-induced stenosis, smooth muscle cell (SMC) differentiation and apoptosis was investigated in rat carotids applying full phosphorothioate antisense ( AS) oligonucleotides (ODNs). Methods: Carotid arteries from WKY rats were submitted to arteriotomy and to local application of ODNs through pluronic gel. Apoptosis ( deoxynucleotidyl transferase-mediated dUTP nick end-labelling), SMC differentiation (SM22 immunofluorescence) and vessel morphology and morphometry ( image analysis) were determined 2, 5 and 30 days after injury, respectively. Results: AS ODNs induced a 60% decrease of target c-Myc mRNA 4 h after surgery in comparison to control sense ( S) and scrambled ODN-treated carotids (p < 0.05). A significant 37 and 50% decrease in SM22 protein in the media of S ODN-treated and untreated carotids was detected when compared to uninjured contralateral arteries (p < 0.05). This reduction in SM22 expression was prevented in AS ODN-treated carotids. Stenosis was mainly due to adventitial constrictive remodelling. Lumen area in AS ODN-treated carotids was 35% greater than in control arteries 30 days after surgery (p < 0.05). TUNEL assay revealed increased apoptosis in AS ODN-treated carotids (p < 0.05). Conclusions: c-Myc AS ODNs reduce arteriotomy-induced negative remodelling. This is accompanied by maintained SMC differentiation and greater apoptosis. The combination of reduced c-Myc-induced proliferation and increased apoptosis may thus underlie the less severe remodelling upon treatment with c-Myc mRNA AS ODN.
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| 10. |
- Hawkes, N. C., et al.
(författare)
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Ion transport barrier formation with low injected torque in JET
- 2007
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Ingår i: 34th EPS Conference on Plasma Physics 2007, EPS 2007 - Europhysics Conference Abstracts. - 9781622763344 ; , s. 504-507
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Konferensbidrag (refereegranskat)abstract
- Ion temperature ITB trigger events have been provoked on JET with very low levels of injected torque using a 3He minority ion heating scheme. The evidence indicates that E x B shear driven by toroidal rotation is not important in these ITB triggers, however the ITBs which form are weak and short lived. Evidence from other experiments [4], suggests that higher torque is necessary to establish and maintain strong ITBs. Future experiments with the increased RF power of the new JET ICRH antenna will be made to explore whether 'strong' ITBs can be created at high power and low applied torque.
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