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| 2. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 6. |
- Khalifa, Shaden A. M., et al.
(författare)
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Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications
- 2021
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Ingår i: Marine Drugs. - : MDPI AG. - 1660-3397 .- 1660-3397. ; 19:5
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Forskningsöversikt (refereegranskat)abstract
- Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.
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| 7. |
- Bin-Jumah, May, et al.
(författare)
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Acrylamide-induced peripheral neuropathy : manifestations, mechanisms, and potential treatment modalities
- 2021
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Ingår i: Environmental Science and Pollution Research. - : Springer. - 0944-1344 .- 1614-7499. ; 28:11, s. 13031-13046
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Forskningsöversikt (refereegranskat)abstract
- Acrylamide is a chemical monomer; its polymer compounds are used in the manufacture of plastic, papers, adhesive tapes, dyes, and food packaging. Lately, scientists found that cooking (mainly roasting, baking, and frying) yields acrylamide. In addition to fried/baked potatoes, coffee and bakery products still contain substantial amounts of acrylamide. Acrylamide has toxic effects on different body systems include genitourinary, reproductive, nervous system, along with being a carcinogenic substance. The neurotoxicity of acrylamide includes central and peripheral neuropathy. In humans, the clinical manifestations include sensory or motor peripheral neuropathy, drowsiness, or cerebellar ataxia. Likewise, it presents with skeletal muscle weakness, hindlimb dysfunction, ataxia, and weight loss in animals. The suggested mechanisms for acrylamide neurotoxicity include direct inhibition of neurotransmission, cellular changes, inhibition of key cellular enzymes, and bonding of kinesin-based fast axonal transport. Moreover, it is suggested that acrylamide's molecular effect on SNARE core kinetics is carried out through the adduction of NSF and/or SNARE proteins. Lately, scientists showed disruption of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) cell signaling pathways in human differentiating neuroblastoma SH-SY5Y cells, exposed to acrylamide. Different treatment modalities have been revealed to shield against or hasten recovery from acrylamide-induced neuropathy in preclinical studies, including phytochemical, biological, and vitamin-based compounds. Still, additional studies are needed to elucidate the pathogenesis and to identify the best treatment modality.
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| 8. |
- Samak, Dalia H., et al.
(författare)
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Developmental toxicity of carbon nanoparticles during embryogenesis in chicken
- 2020
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Ingår i: Environmental Science and Pollution Research. - : Springer Nature. - 0944-1344 .- 1614-7499. ; 27:16, s. 19058-19072
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Tidskriftsartikel (refereegranskat)abstract
- Nanoparticles (NPs) are very small particles present in a wide range of materials. There is a dearth of knowledge regarding their potential secondary effects on the health of living organisms and the environment. Increasing research attention, however, has been directed toward determining the effects on humans exposed to NPs in the environment. Although the majority of studies focus on adult animals or populations, embryos of various species are considered more susceptible to environmental effects and pollutants. Hence, research studies dealing mainly with the impacts of NPs on embryogenesis have emerged recently, as this has become a major concern. Chicken embryos occupy a special place among animal models used in toxicity and developmental investigations and have also contributed significantly to the fields of genetics, virology, immunology, cell biology, and cancer. Their rapid development and easy accessibility for experimental observance and manipulation are just a few of the advantages that have made them the vertebrate model of choice for more than two millennia. The early stages of chicken embryogenesis, which are characterized by rapid embryonic growth, provide a sensitive model for studying the possible toxic effects on organ development, body weight, and oxidative stress. The objective of this review was to evaluate the toxicity of various types of carbon black nanomaterials administered at the beginning of embryogenesis in a chicken embryo model. In addition, the effects of diamond and graphene NPs and carbon nanotubes are reviewed.
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| 9. |
- Yossa, M. T., et al.
(författare)
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Remote sensing and geographic information system (GIS)-based high-resolution mapping of potential groundwater recharge zones on the hard rock terrains of the Cameroon volcanic line (CVL)
- 2023
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Ingår i: Sn Applied Sciences. - : Springer Science and Business Media LLC. - 2523-3963 .- 2523-3971. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- Groundwater is the major water reserve in the present context of global warming-related droughts that appear to be more intense in hard rock terrains. The use of Geographical Information Systems (GIS) and Remote Sensing (RS) technologies are increasingly beneficial to groundwater research, by allowing for low cost and larger-scale high-resolution mapping compared to conventional hydrogeological exploration methods. This study aimed at developing a high-resolution map of potential groundwater recharge (GWR(pot)) zones for the drought-stricken Banka hard rock terrain, straddling the Cameroon Volcanic Line (CVL). Shuttle Radar Tomography Mission (SRTM)-30m and Landsat 8 satellite images constituted the main data source that was ground-truthed through field mapping and used to produce various thematic GIS layers: geology slope, aspect, land use & land cover, drainage density and lineament density of spatial resolution 16m x 16m. The layers were each attributed a fixed score and weight to groundwater recharge, computed using Multi-Influencing Factor (MIF) and Analytical Hierarchy Process of Multi-Criteria Decision Analysis (AHP-MCDA) techniques. Lastly, a Weighted Overlay Analysis was done using the layers to produce the GWR(pot) zones for the study area. The resulting map shows that 60% of the study area, covering the south, west-northwest and the north-northeast portions of the map have moderate to very high recharge potentials. This result is particularly useful for groundwater targeting in the area and demonstrates the effectiveness of the method in hard rock terrains where traditional methods have been less efficient in properly delineating groundwater recharge zones.
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| 10. |
- Ahlawat, Paramvir, et al.
(författare)
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A combined molecular dynamics and experimental study of two-step process enabling low-temperature formation of phase-pure alpha-FAPbI3
- 2021
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 7:17
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Tidskriftsartikel (refereegranskat)abstract
- It is well established that the lack of understanding the crystallization process in a two-step sequential deposition has a direct impact on efficiency, stability, and reproducibility of perovskite solar cells. Here, we try to understand the solid-solid phase transition occurring during the two-step sequential deposition of methylammonium lead iodide and formamidinium lead iodide. Using metadynamics, x-ray diffraction, and Raman spectroscopy, we reveal the microscopic details of this process. We find that the formation of perovskite proceeds through intermediate structures and report polymorphs found for methylammonium lead iodide and formamidinium lead iodide. From simulations, we discover a possible crystallization pathway for the highly efficient metastable alpha phase of formamidinium lead iodide. Guided by these simulations, we perform experiments that result in the low-temperature crystallization of phase-pure alpha-formamidinium lead iodide.
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