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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 3. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
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| 5. |
- Becker, Christoph, et al.
(författare)
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Temporal discounting in technical debt : How do software practitioners discount the future?
- 2019
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Ingår i: Proceedings - 2019 IEEE/ACM International Conference on Technical Debt, TechDebt 2019. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728133713 ; , s. 23-32
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Konferensbidrag (refereegranskat)abstract
- Technical Debt management decisions always imply a trade-off among outcomes at different points in time. In such intertemporal choices, distant outcomes are often valued lower than close ones, a phenomenon known as temporal discounting. Technical Debt research largely develops prescriptive approaches for how software engineers should make such decisions. Few have studied how they actually make them. This leaves open central questions about how software practitioners make decisions. This paper investigates how software practitioners discount uncertain future outcomes and whether they exhibit temporal discounting. We adopt experimental methods from intertemporal choice, an active area of research. We administered an online questionnaire to 33 developers from two companies in which we presented choices between developing a feature and making a longer-term investment in architecture. The results show wide-spread temporal discounting with notable differences in individual behavior. The results are consistent with similar studies in consumer behavior and raise a number of questions about the causal factors that influence temporal discounting in software engineering. As the first empirical study on intertemporal choice in SE, the paper establishes an empirical basis for understanding how software developers approach intertemporal choice and provides a blueprint for future studies. © 2019 IEEE.
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| 6. |
- Bärgman, Jonas, 1972, et al.
(författare)
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The UDrive dataset and key analysis results
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- UDrive is a large European naturalistic driving study, sponsored by the European Commission (FP7).Nineteen partners across Europe have come together and, along with stakeholders, defined researchquestions, developed data acquisition, collected and managed data, and finally, performed a first analysis onthe UDrive dataset with respect to driver/rider behaviour related to traffic safety and the environment (ecodriving).This document presents key results of the UDrive analysis performed in UDrive Sub-project 4: Data analysis.It also describes the UDrive dataset and, in brief, how we got here.
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| 7. |
- Caso, Giuseppe, et al.
(författare)
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Monitoring and Analytics (Release A)
- 2019
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Rapport (refereegranskat)abstract
- This document describes the design and implementation of the 5GENESIS Monitoring & Analytics (M&A) framework (Release A), developed within Task T3.3 of the Project work plan.
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| 8. |
- Fagerholm, Fabian, et al.
(författare)
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Temporal Discounting in Software Engineering : A Replication Study
- 2019
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Ingår i: International Symposium on Empirical Software Engineering and Measurement. - : IEEE Computer Society. - 9781728129686
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Konferensbidrag (refereegranskat)abstract
- Background: Many decisions made in Software Engineering practices are intertemporal choices: trade-offs in time between closer options with potential short-term benefit and future options with potential long-term benefit. However, how software professionals make intertemporal decisions is not well understood. Aim: This paper investigates how shifting time frames influence preferences in software projects in relation to purposefully selected background factors. Method: We investigate temporal discounting by replicating a questionnaire-based observational study. The replication uses a changed-population and -experimenter design to increase the internal and external validity of the original results. Results: The results of this study confirm the occurrence of temporal discounting in samples of both professional and student participants from different countries and demonstrate strong variance in discounting between study participants. We found that professional experience influenced discounting. Participants with broader professional experience exhibited less discounting than those with narrower experience. Conclusions: The results provide strong empirical support for the relevance and importance of temporal discounting in SE and the urgency of targeted interdisciplinary research to explore the underlying mechanisms and their theoretical and practical implications. The results suggest that technical debt management could be improved by increasing the breadth of experience available for critical decisions with long-term impact. In addition, the present study provides a methodological basis for replicating temporal discounting studies in software engineering. © 2019 IEEE.
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| 9. |
- Lien, Sigbjorn, et al.
(författare)
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The Atlantic salmon genome provides insights into rediploidization
- 2016
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 533:7602, s. 200-205
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Tidskriftsartikel (refereegranskat)abstract
- The whole-genome duplication 80 million years ago of the common ancestor of salmonids (salmonid-specific fourth vertebrate whole-genome duplication, Ss4R) provides unique opportunities to learn about the evolutionary fate of a duplicated vertebrate genome in 70 extant lineages. Here we present a high-quality genome assembly for Atlantic salmon (Salmo salar), and show that large genomic reorganizations, coinciding with bursts of transposon-mediated repeat expansions, were crucial for the post-Ss4R rediploidization process. Comparisons of duplicate gene expression patterns across a wide range of tissues with orthologous genes from a pre-Ss4R outgroup unexpectedly demonstrate far more instances of neofunctionalization than subfunctionalization. Surprisingly, we find that genes that were retained as duplicates after the teleost-specific whole-genome duplication 320 million years ago were not more likely to be retained after the Ss4R, and that the duplicate retention was not influenced to a great extent by the nature of the predicted protein interactions of the gene products. Finally, we demonstrate that the Atlantic salmon assembly can serve as a reference sequence for the study of other salmonids for a range of purposes.
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| 10. |
- Längin, Matthias, et al.
(författare)
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Consistent success in life-supporting porcine cardiac xenotransplantation
- 2018
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 564:7736, s. 430-433
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Tidskriftsartikel (refereegranskat)abstract
- Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply of allogeneic donor organs falls far short of the clinical need1–3. Xenotransplantation of genetically modified pig hearts has been discussed as a potential alternative4. Genetically multi-modified pig hearts that lack galactose-α1,3-galactose epitopes (α1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantation in baboons5. This model demonstrated long-term acceptance of discordant xenografts with safe immunosuppression but did not predict their life-supporting function. Despite 25 years of extensive research, the maximum survival of a baboon after heart replacement with a porcine xenograft was only 57 days and this was achieved, to our knowledge, only once6. Here we show that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and control of post-transplantation growth to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model. Consistent life-supporting function of xenografted hearts for up to 195 days is a milestone on the way to clinical cardiac xenotransplantation7.
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