| 1. |
- Farewell, Anne, 1961, et al.
(författare)
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The potential improvement of team-working skills in Biomedical and Natural Science students using a problem-based learning approach.
- 2013
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Ingår i: Journal of Problem Based Learning in Higher Education. - 2246-0918. ; 1:1, s. 84-93
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Tidskriftsartikel (refereegranskat)abstract
- Teamwork has become an integral part of most organisations today, and it is clearly important in Science and other disciplines. In Science, research teams increase in size while the number of single-authored papers and patents decline. Team-work in laboratory sciences permits projects that are too big or complex for one individual to be tackled. This development requires that students gain experience of team-work before they start their professional career. Students working in teams this may increase productivity, confidence, innovative capacity and improvement of interpersonal skills. Problem-based learning (PBL) is an instructional approach focusing on real analytical problems as a means of training an analytical scientist. PBL may have a positive impact on team-work skills that are important for undergraduates and postgraduates to enable effective collaborative work. This survey of the current literature explores the development of the team-work skills in Biomedical Science students using PBL.
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| 2. |
- Persson, Örjan, 1974, et al.
(författare)
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UspB, a member of the sigma-S regulon, facilitates RuvC resolvase function.
- 2010
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Ingår i: DNA repair. - : Elsevier BV. - 1568-7856 .- 1568-7864. ; 9:11, s. 1162-9
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Tidskriftsartikel (refereegranskat)abstract
- A growing body of evidence shows that there is an intimate connection between proteins required for genome stability and stationary phase survival. In this work we show that the integral membrane protein UspB, a member of the RpoS regulon, is required for proper DNA repair as mutants lacking uspB are hypersensitive to several DNA damaging agents including ultraviolet light, mitomycin C, bleomycin and ciprofloxacin. Genetic and physical studies demonstrate that UspB acts in the RuvABC recombination repair pathway and removing uspB creates a phenocopy of the Holliday junction resolvase mutant, ruvC. Further, we show that the uspB mutant phenotype can be suppressed by ectopic overproduction of RuvC and that both ruvC and uspB mutants can be suppressed by inactivating recD. The fact that RuvABC-dependent repair requires UspB for proper activity suggests that the sigma-S regulon works together with DNA repair pathways under stress conditions to defend the cell against genotoxic stress.
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