SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Faucher P) srt2:(2020-2022)"

Sökning: WFRF:(Faucher P) > (2020-2022)

  • Resultat 1-4 av 4
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Faucher, Sebastien P., et al. (författare)
  • Toxoflavin secreted by Pseudomonas alcaliphila inhibits the growth of Legionella pneumophila and Vermamoeba vermiformis
  • 2022
  • Ingår i: Water Research. - : Elsevier. - 0043-1354 .- 1879-2448. ; 216
  • Tidskriftsartikel (refereegranskat)abstract
    • Legionella pneumophila is a natural inhabitant of water systems. From there, it can be transmitted to humans by aerosolization resulting in severe pneumonia. Most large outbreaks are caused by cooling towers colonized with L. pneumophila. The resident microbiota of the cooling tower is a key determinant for the colonization and growth of L. pneumophila. In our preceding study, the genus Pseudomonas correlated negatively with the presence of L. pneumophila in cooling towers, but it was not clear which species was responsible. Therefore, we identified the Pseudomonas species inhabiting 14 cooling towers using a Pseudomonas-specific 16S rRNA amplicon sequencing strategy. We found that cooling towers that are free of L. pneumophila contained a high relative abundance of members from the Pseudomonas alcaliphila/oleovorans phylogenetic cluster. P. alcaliphila JCM 10630 inhibited the growth of L. pneumophila on agar plates. Analysis of the P. alcaliphila genome revealed the presence of a gene cluster predicted to produce toxoflavin. L. pneumophila growth was inhibited by pure toxoflavin and by extracts from P. alcaliphila culture found to contain toxoflavin by liquid chromatography coupled with mass spectrometry. In addition, toxoflavin inhibits the growth of Vermameoba vermiformis, a host cell of L. pneumophila. Our study indicates that P. alcaliphila may be important to restrict growth of L. pneumophila in water systems through the production of toxoflavin. A sufficiently high concentration of toxoflavin is likely not achieved in the bulk water but might have a local inhibitory effect such as near or in biofilms.
  •  
2.
  • Hernandez, Svea, et al. (författare)
  • First Cospatial Comparison of Stellar, Neutral-gas, and Ionized-gas Metallicities in a Metal-rich Galaxy : M83
  • 2021
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 908:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We carry out a comparative analysis of the metallicities from the stellar, neutral-gas, and ionized-gas components in the metal-rich spiral galaxy M83. We analyze spectroscopic observations taken with the Hubble Space Telescope, the Large Binocular Telescope, and the Very Large Telescope. We detect a clear depletion of the H i gas, as observed from the H i column densities in the nuclear region of this spiral galaxy. We find column densities of log[N(H i) cm−2] < 20.0 at galactocentric distances of <0.18 kpc, in contrast to column densities of log[N(H i) cm−2] ~ 21.0 in the galactic disk, a trend observed in other nearby spiral galaxies. We measure a metallicity gradient of −0.03 ± 0.01 dex kpc−1 for the ionized gas, comparable to the metallicity gradient of a local benchmark of 49 nearby star-forming galaxies of −0.026 ± 0.002 dex kpc−1. Our cospatial metallicity comparison of the multiphase gas and stellar populations shows excellent agreement outside of the nucleus of the galaxy, hinting at a scenario where the mixing of newly synthesized metals from the most massive stars in the star clusters takes longer than their lifetimes (~10 Myr). Finally, our work shows that caution must be taken when studying the metallicity gradient of the neutral-gas component in star-forming galaxies, since this can be strongly biased, as these environments can be dominated by molecular gas. In these regions the typical metallicity tracers can provide inaccurate abundances, as they may trace both the neutral- and molecular-gas components.
  •  
3.
  • Paranjape, Kiran, et al. (författare)
  • Bacterial Antagonistic Species of the Pathogenic Genus Legionella Isolated from Cooling Tower
  • 2022
  • Ingår i: Microorganisms. - : MDPI AG. - 2076-2607. ; 10:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Legionella pneumophila is the causative agent of Legionnaires' disease, a severe pneumonia. Cooling towers are a major source of large outbreaks of the disease. The growth of L. pneumophila in these habitats is influenced by the resident microbiota. Consequently, the aim of this study was to isolate and characterize bacterial species from cooling towers capable of inhibiting several strains of L. pneumophila and one strain of L. quinlivanii. Two cooling towers were sampled to isolate inhibiting bacterial species. Seven inhibitory isolates were isolated, through serial dilution plating and streaking on agar plates, belonging to seven distinct species. The genomes of these isolates were sequenced to identify potential genetic elements that could explain the inhibitory effect. The results showed that the bacterial isolates were taxonomically diverse and that one of the isolates may be a novel species. Genome analysis showed a high diversity of antimicrobial gene products identified in the genomes of the bacterial isolates. Finally, testing different strains of Legionella demonstrated varying degrees of susceptibility to the antimicrobial activity of the antagonistic species. This may be due to genetic variability between the Legionella strains. The results demonstrate that though cooling towers are breeding grounds for L. pneumophila, the bacteria must contend with various antagonistic species. Potentially, these species could be used to create an inhospitable environment for L. pneumophila, and thus decrease the probability of outbreaks occurring.
  •  
4.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-4 av 4

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy