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Expression of p53 p...
Expression of p53 protein in high-grade gastroenteropancreatic neuroendocrine carcinoma
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- Ali, Abir Salwa (författare)
- Uppsala universitet,Onkologisk endokrinologi
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- Grönberg, Malin, 1980- (författare)
- Uppsala universitet,Onkologisk endokrinologi
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- Federspiel, Birgitte (författare)
- Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark
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- Scoazec, Jean-Yves (författare)
- Inst Gustave Roussy, Villejuif, France
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- Hjortland, Geir Olav (författare)
- Univ Oslo, Oslo, Norway
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- Gronbaek, Henning (författare)
- Aarhus Univ Hosp, Aarhus, Denmark
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- Ladekarl, Morten (författare)
- Aarhus Univ Hosp, Aarhus, Denmark
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- Langer, Seppo W. (författare)
- Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark
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- Welin, Staffan (författare)
- Uppsala universitet,Onkologisk endokrinologi
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- Vestermark, Lene Weber (författare)
- Odense Univ Hosp, Odense, Denmark
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- Arola, Johanna (författare)
- Univ Helsinki, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
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- Osterlund, Pia (författare)
- Univ Helsinki, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland; Tampere Univ Hosp, Tampere, Finland
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- Knigge, Ulrich (författare)
- Univ Copenhagen, Rigshosp, Copenhagen, Denmark
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- Sorbye, Halfdan (författare)
- Haukeland Hosp, Bergen, Norway; Univ Bergen, Bergen, Norway
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- Grimelius, Lars (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Tiensuu Janson, Eva (författare)
- Uppsala universitet,Onkologisk endokrinologi,Uppsala Univ, Sect Endocrine Oncol, Dept Med Sci, Uppsala, Sweden.
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(creator_code:org_t)
- 2017-11-07
- 2017
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:11
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) are aggressive, rapidly proliferating tumors. Therapeutic response to current chemotherapy regimens is usually short lasting. The aim of this study was to examine the expression and potential clinical importance of immunoreactive p53 protein in GEP-NEC. Materials and methods Tumor tissues from 124 GEP-NEC patients with locally advanced or metastatic disease treated with platinum-based chemotherapy were collected from Nordic centers and clinical data were obtained from the Nordic NEC register. Tumor proliferation rate and differentiation were re-evaluated. All specimens were immunostained for p53 protein using a commercially available monoclonal antibody. Kaplan-Meier curves and cox regression analyses were used to assess progression-free survival (PFS) and overall survival (OS). Results All tumor tissues were immunoreactive for either one or both neuroendocrine biomarkers (chromogranin A and synaptophysin) and Ki67 index was >20% in all cases. p53 immunoreactivity was only shown in 39% of the cases and was not found to be a prognostic marker for the whole cohort. However, p53 immunoreactivity was correlated with shorter PFS in patients with colorectal tumors (HR = 2.1, p = 0.03) in a univariate analysis as well as to poorer PFS (HR = 2.6, p = 0.03) and OS (HR = 3.4, p = 0.02) in patients with colorectal tumors with distant metastases, a correlation which remained significant in the multivariate analyses. Conclusion In this cohort of GEP-NEC patients, p53 expression could not be correlated with clinical outcome. However, in patients with colorectal NECs, p53 expression was correlated with shorter PFS and OS. Further studies are needed to establish the role of immunoreactive p53 as a prognostic marker for GEP-NEC patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Ali, Abir Salwa
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Grönberg, Malin, ...
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Federspiel, Birg ...
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Scoazec, Jean-Yv ...
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Hjortland, Geir ...
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Gronbaek, Hennin ...
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Ladekarl, Morten
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Langer, Seppo W.
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Welin, Staffan
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Vestermark, Lene ...
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Arola, Johanna
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Osterlund, Pia
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Knigge, Ulrich
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Sorbye, Halfdan
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Grimelius, Lars
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Tiensuu Janson, ...
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