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Brain dysfunction i...
Brain dysfunction in tubular and tubulointerstitial kidney diseases
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- Viggiano, Davide (författare)
- Univ Campania L Vanvitelli, Italy; Biogem, Italy
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- Bruchfeld, Annette (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Karolinska Univ Hosp, Sweden; CLINTEC Karolinska Inst, Sweden
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- Carriazo, Sol (författare)
- IIS Fdn Jimenez Diaz UAM, Spain
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- de Donato, Antonio (författare)
- Karolinska Univ Hosp, Sweden; CLINTEC Karolinska Inst, Sweden; IIS Fdn Jimenez Diaz UAM, Spain
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- Endlich, Nicole (författare)
- Univ Med Greifswald, Germany
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- Ferreira, Ana Carina (författare)
- Ctr Hosp & Univ Lisboa Cent, Portugal; Univ Nova Lisboa, Portugal
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- Figurek, Andreja (författare)
- Univ Zurich, Switzerland
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- Fouque, Denis (författare)
- Univ Lyon, France
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- Franssen, Casper F. M. (författare)
- Univ Groningen, Netherlands
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- Giannakou, Konstantinos (författare)
- European Univ Cyprus, Cyprus
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- Goumenos, Dimitrios (författare)
- Patras Univ Hosp, Greece
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- Hoorn, Ewout J. (författare)
- Erasmus MC, Netherlands
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- Nitsch, Dorothea (författare)
- London Sch Hyg & Trop Med, England
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- Ortiz, Alberto (författare)
- IIS Fdn Jimenez Diaz UAM, Spain
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- Pesic, Vesna (författare)
- Univ Belgrade, Serbia
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- Rastenyte, Daiva (författare)
- Lithuanian Univ Hlth Sci, Lithuania
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- Soler, Maria Jose (författare)
- Vall dHebron Barcelona Hosp Campus, Spain
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- Rroji, Merita (författare)
- Univ Hosp Ctr Mother Tereza, Albania
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- Trepiccione, Francesco (författare)
- Univ Campania L Vanvitelli, Italy; Biogem, Italy
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- Unwin, Robert J. (författare)
- UCL, England
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- Wagner, Carsten A. (författare)
- Univ Zurich, Switzerland
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- Wiecek, Andrzej (författare)
- Med Univ Silesia, Poland
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- Zacchia, Miriam (författare)
- Univ Campania L Vanvitelli, Italy; Biogem, Italy
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- Zoccali, Carmine (författare)
- Renal Res Inst, NY USA; Assoc Ipertens Nefrol Trapianto Renale, Italy
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- Capasso, Giovambattista (författare)
- Univ Campania L Vanvitelli, Italy; Biogem, Italy
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(creator_code:org_t)
- 2021-11-18
- 2022
- Engelska.
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Ingår i: Nephrology, Dialysis and Transplantation. - : Oxford University Press. - 0931-0509 .- 1460-2385. ; 37, s. 45-54
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Kidney function has two important elements: glomerular filtration and tubular function (secretion and reabsorption). A persistent decrease in glomerular filtration rate (GFR), with or without proteinuria, is diagnostic of chronic kidney disease (CKD). While glomerular injury or disease is a major cause of CKD and usually associated with proteinuria, predominant tubular injury, with or without tubulointerstitial disease, is typically non-proteinuric. CKD has been linked with cognitive impairment, but it is unclear how much this depends on a decreased GFR, altered tubular function or the presence of proteinuria. Since CKD is often accompanied by tubular and interstitial dysfunction, we explore here for the first time the potential role of the tubular and tubulointerstitial compartments in cognitive dysfunction. To help address this issue we selected a group of primary tubular diseases with preserved GFR in which to review the evidence for any association with brain dysfunction. Cognition, mood, neurosensory and motor disturbances are not well characterized in tubular diseases, possibly because they are subclinical and less prominent than other clinical manifestations. The available literature suggests that brain dysfunction in tubular and tubulointerstitial diseases is usually mild and is more often seen in disorders of water handling. Brain dysfunctionmay occur when severe electrolyte and water disorders in young children persist over a long period of time before the diagnosis is made. We have chosen Bartter and Gitelman syndromes and nephrogenic diabetes insipidus as examples tohighlight this topic. Wediscuss current published findings, some unanswered questions and propose topics for future research.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- brain; chronic kidney disease; cognitive function; electrolyte; tubulointerstitial
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Till lärosätets databas
- Av författaren/redakt...
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Viggiano, Davide
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Bruchfeld, Annet ...
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Carriazo, Sol
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de Donato, Anton ...
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Endlich, Nicole
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Ferreira, Ana Ca ...
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visa fler...
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Figurek, Andreja
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Fouque, Denis
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Franssen, Casper ...
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Giannakou, Konst ...
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Goumenos, Dimitr ...
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Hoorn, Ewout J.
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Nitsch, Dorothea
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Ortiz, Alberto
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Pesic, Vesna
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Rastenyte, Daiva
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Soler, Maria Jos ...
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Rroji, Merita
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Trepiccione, Fra ...
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Unwin, Robert J.
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Wagner, Carsten ...
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Wiecek, Andrzej
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Zacchia, Miriam
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Zoccali, Carmine
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Capasso, Giovamb ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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Nephrology, Dial ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet