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Characterization of...
Characterization of the Biological Activity of the Ethanolic Extract from the Roots of Cannabis sativa L. Grown in Aeroponics
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- Ferrini, Fabio (författare)
- University of Urbino
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- Donati Zeppa, Sabrina (författare)
- University of Urbino
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- Fraternale, Daniele (författare)
- University of Urbino
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- Carrabs, Vittoria (författare)
- University of Urbino
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- Annibalini, Giosuè (författare)
- University of Urbino
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- Verardo, Giancarlo (författare)
- University of Udine
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- Gorassini, Andrea (författare)
- University of Udine
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- Albertini, Maria Cristina (författare)
- University of Urbino
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- Ismail, Tariq (författare)
- Lund University,Lunds universitet,Avdelningen för livsmedel och läkemedel,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Food and Pharma,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH,Bahauddin Zakariya University
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- Fimognari, Carmela (författare)
- University of Bologna
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- Sestili, Piero (författare)
- University of Urbino
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(creator_code:org_t)
- 2022-04-27
- 2022
- Engelska.
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Ingår i: Antioxidants. - : MDPI AG. - 2076-3921. ; 11:5
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Cannabis sativa var. Kompolti, a variety routinely used for food production purposes, is characterized by a low concentration of psychoactive molecules, although containing many other biologically attractive metabolites in all parts of the plant, including the roots. In the present work, we evaluate the specific biological activities of the roots’ extract from plants cultivated through aeroponics, an affordable and reliable method facilitating the isolation and processing of roots, with the advantage of being suitable for industrial scale‐up. Furthermore, aeroponics results in an increased net accumulation of the most biologically attractive constituents (β‐sitosterol, friedelin and epi‐friedelanol) found in the roots. The ethanolic extract of the aeroponic roots of C. sativa (APEX) and its separate components are studied to evaluate their anti‐inflammatory (modulation of the expression level of specific markers upon LPS stimulation in U937 cells, such as IL‐6, IL‐8, TNF‐α, IkB‐α, iNOS, IRAK‐1 and miR‐146a) and antioxidant (in either acellular or cellular settings) activities. The APEX anti‐inflammatory and antioxidant capacities are also functionally benchmarked using the wound‐healing assay. On the whole, the data obtained show that APEX and its main components showed significant anti‐inflammatory and antioxidant activities, which may render the exploitation of roots as a source of natural antioxidants and anti‐inflammatory agents highly attrac-tive, with the additional technical and economic advantages of aeroponics compared to soil cultivation.
Ämnesord
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Växtbioteknologi (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Plant Biotechnology (hsv//eng)
Nyckelord
- aeroponic roots
- antioxidant
- anti‐inflammatory
- Cannabis sativa L.
- epi‐friedelanol
- friedelin
- β‐sitosterol
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Ferrini, Fabio
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Donati Zeppa, Sa ...
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Fraternale, Dani ...
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Carrabs, Vittori ...
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Annibalini, Gios ...
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Verardo, Giancar ...
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visa fler...
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Gorassini, Andre ...
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Albertini, Maria ...
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Ismail, Tariq
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Fimognari, Carme ...
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Sestili, Piero
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