| 1. |
- Flygare, Oskar, et al.
(författare)
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Association of anxiety or depression with risk of recurrent cardiovascular events and death after myocardial infarction : A nationwide registry study
- 2023
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Ingår i: International Journal of Cardiology. - 0167-5273 .- 1874-1754. ; 381, s. 120-127
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Tidskriftsartikel (refereegranskat)abstract
- Background: Depression and anxiety are risk factors for patients with myocardial infarction (MI). However, the association of a previous psychiatric diagnosis of anxiety or depression, or only such self-reported symptoms, with cardiovascular outcomes and mortality post-MI has not been previously examined in the same nationwide cohort. Methods: We linked demographic, socioeconomic and clinical data from four nationwide Swedish registries for patients enrolled in cardiac rehabilitation (CR) after first-time MI (2006–2015, N = 45,096). After multiple imputation, we applied Cox regression to estimate the post-MI outcome risk for patients with a previous psychiatric diagnosis of anxiety/depression (Diagnosis), patients with no formal diagnosis but self-reported symptoms of anxiety/depression (Symptoms), versus patients with neither Diagnosis nor Symptoms (Reference). Results: During one-year follow-up, fully adjusted models showed that patients with Diagnosis had a higher risk (hazard ratio [95%CI]) of all-cause mortality (1.86 [1.36, 2.53]), reinfarction (1.14 [1.06, 1.22]), their composite (1.15 [1.07, 1.23]), and an extended cardiovascular composite (1.19 [1.12, 1.26]), versus Reference, even though 77% reported no symptoms at the time of MI. In patients with Symptoms, estimates were also elevated yet somewhat attenuated compared to Reference. Findings were overall robust across multiple sensitivity analyses. Conclusions: Both a previous diagnosis, and present self-reported symptoms of anxiety or depression are associated with an increased risk of death and recurrent cardiovascular events in adults with first-time MI. Only screening for present symptoms is inadequate for assessing this excessive risk. Assessment of both psychiatric history and self-reported symptoms seems warranted for these patients.
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| 2. |
- Hjalmarsson, Johannes, et al.
(författare)
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Enhancing the value of large-scale energy storage systems in congested distribution grids using service stacking
- 2023
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Ingår i: Journal of Energy Storage. - 2352-152X .- 2352-1538.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Energy storage systems (ESS) are suitable for many grid applications, where some have large seasonal variations. By combining additional services, i.e., service stacking, companies with energy storage assets may generate additional revenue as well as provide services to the power system. This paper aims to highlight and estimate the technical and economic potential of stacking services using energy storage systems in congested a distribution grid. A scheduling optimization tool was implemented for a large-scale battery ESS providing a selection of deemed relevant services over two years. The results show that there is a great potential to enhance the value of the ESS significantly depending on the service portfolio layout. A capacity life loss model was also implemented to analyse the degradation of the ESS, and the cycle aging was estimated for the chosen portfolios. The results showed that a fully stacked portfolio does not necessarily result in increased cycle aging, but that it depended on the services in the portfolio. The cycle aging was affected the most by stacking flexibility with energy arbitrage, while frequency regulation services only resulted in a few additional cycles during each year of operation.
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| 3. |
- Ivanova, Ekaterina, et al.
(författare)
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Study protocol for a single-blind, parallel-group, randomised, controlled non-inferiority trial of 4-day intensive versus standard cognitive behavioural therapy for adults with obsessive-compulsive disorder
- 2023
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 13:12
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Individual cognitive behavioural therapy (CBT) with exposure and response prevention is an effective treatment for obsessive-compulsive disorder (OCD). However, individual CBT is costly and time-consuming, requiring weekly therapy sessions for 3-4 months. A 4-day intensive version of CBT for OCD delivered in group format has been recently developed in Norway (Bergen 4-day treatment, B4DT). B4DT has shown promising results in several uncontrolled and one small, randomised trial, but its non-inferiority to the gold standard treatment has not been established. Methods and analysis This single-blind, randomised controlled trial including 120 patients (60 per arm) will compare B4DT to individual CBT. The primary outcome is the blind assessor-rated Yale-Brown Obsessive Compulsive Scale (Y-BOCS). We hypothesise that B4DT will be non-inferior to gold standard CBT 15 weeks after treatment start. The non-inferiority margin is set at four points on the Y-BOCS. Secondary outcomes include time to treatment response, cost-effectiveness, response and remission rates, drop-out rates and adverse events. Ethics and dissemination This study has been approved by the Swedish Ethical Review Authority. Hypotheses were specified and analysis code published before data collection started. Results from all analyses will be reported in accordance with the Consolidated Standards of Reporting Trials statement for non-pharmacological trials and Consolidated Health Economic Evaluation Reporting Standards irrespective of outcome. Trial registration number NCT05608278.
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