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- Agelis, Sacki
(författare)
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Reconfigurable Optical Interconnection Networks for High-Performance Embedded
- 2005
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In embedded computer and communication system the capacity demand for interconnection networks is increasing continuously in order to achieve high-performance systems. Recent breakthroughs show that by using reconfigurability inside a single chip substantial performance gains can be added. However, in this thesis the focus is on system level reconfigurability (between chips or modules) and the performance gains that potentially can be achieved by having support for runtime reconfigurability on the system level.This thesis addresses the field of runtime system level reconfigurability with the use of optics in switches and routers for data- and telecommunications, and in multi-processor systems used for embedded signal processing. Several reconfigurable systems for switching and routing with support to adapt for asymmetric traffic patterns are proposed and compared to identify how design choices affect flexibility, performance etc. The proposed solutions are characterized by their multistage optical interconnection networks with reconfigurable shuffle patterns, where the reconfigurability is provided by micro-optical-electrical mechanical systems. More specifically, application-specific bottlenecks can be resolved by reconfiguring the interconnection network according to the current application demands. The benefits of the architectural solutions are confirmed by simulations that clearly show that the architectures can achieve high performance for both symmetric application characteristics and for several classes of asymmetric application characteristics. The final architectural solution is characterized by electronic packet-switches interconnected through an optical backplane, which is reconfigurable. Moreover, the thesis presents how several signal processing applications can be mapped to run concurrently in a time-shared scheme on a single reconfigurable multi-processor system that has high flexibility to adapt for the application currently at hand. The interconnection network is then adapted (reconfigured) according to the demands of the currently executed application in each time instance. The analysis shows that it is feasible to build such a system with today’s components.
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| 3. |
- Brännvall, Karin, et al.
(författare)
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Central nervous system stem/progenitor cells form neurons and peripheral glia after transplantation to the dorsal root ganglion.
- 2006
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Ingår i: NeuroReport. - 0959-4965 .- 1473-558X. ; 17:6, s. 623-628
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Tidskriftsartikel (refereegranskat)abstract
- We asked whether neural stem/progenitor cells from the cerebral cortex of E14.5 enhanced green fluorescent protein transgenic mice are able to survive grafting and differentiate in the adult rat dorsal root ganglion. Neurospheres were placed in lumbar dorsal root ganglion cavities after removal of the dorsal root ganglia. Alternatively, dissociated neurospheres were injected into intact dorsal root ganglia. Enhanced green fluorescent protein-positive cells in the dorsal root ganglion cavity were located in clusters and expressed beta-III-tubulin or glial fibrillary acidic protein after 1 month, whereas after 3 months, surviving grafted cells expressed only glial fibrillary acidic protein. In the intact adult DRG, transplanted neural stem/progenitor cells surrounded dorsal root ganglion cells and fibers, and expressed glial but not neuronal markers. These findings show that central nervous system stem/progenitor cells can survive and differentiate into neurons and peripheral glia after xenotransplantation to the adult dorsal root ganglion.
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| 4. |
- Engqvist, Cecilia, et al.
(författare)
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Interactions between single latex particles and silica surfaces studied with AFM
- 2007
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Ingår i: Colloids and Surfaces A. - : Elsevier BV. - 0927-7757 .- 1873-4359. ; 302:03-jan, s. 197-203
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Tidskriftsartikel (refereegranskat)abstract
- The spreading of single styrene-acrylic latex particles on silicon oxide C surfaces was studied using atomic force microscopy (AFM). Three latexes with different glass transition temperature (Tg) were used and the effects of temperature, time and preparation method were investigated. Particle sizes and shape were measured with AFM and the contact angles were calculated. The observed rate for the spreading of latex particles was low and it took several days before the particles reached steady state, even at temperatures well above their T-g. The experimental particle spreading results deviated with two orders of magnitude from predictions Using the WLF equation for polymer diffusion. The deviation could be attributed to polymer-surface interactions that slowed down the particle spreading. The work of adhesion was calculated using two models. The results from using the regular Young-Dupre equation and a modified version of this equation that also included the mechanical properties (E-modulus and Poisson's ratio) of the latexes, were compared. For soft latex particles the results from the two models agreed well and were of the order of 75 J/m(2), but for glassy latexes the Young-Dupre equation underestimated the work of adhesion.
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| 6. |
- Erikson, Anders, et al.
(författare)
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Ten years' experience of enzyme infusion therapy of Norrbottnian (type 3) Gaucher disease.
- 2006
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Ingår i: Acta Paediatr. - 0803-5253. ; 95:3, s. 312-7
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To study the long-term effects of enzyme replacement therapy on the neurological signs of chronic neuronopathic Gaucher disease and to evaluate some biochemical parameters for monitoring the treatment. METHODS: Eight patients from the Norrbottnian cohort were followed during 10 y of treatment. They were followed with regular clinical observations, biochemical tests and psychometric testing. RESULTS: After the start of treatment, their general well-being improved and was stable during the follow-up. In three of the patients there were some indications of slow neurological deterioration. The mean results of psychometric testing did not decrease. Glucosylceramide and chitotriosidase levels were useful in monitoring the treatment. The chemokine CCL18 also seems to be a useful parameter for future monitoring. CONCLUSIONS: Enzyme replacement therapy seems to slow down further neurological and mental deterioration in mild chronic neuronopathic (type 3) Gaucher disease.
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| 7. |
- Forsberg, Anders, et al.
(författare)
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Landmark-Based Software for Anatomical Measurements : A Precision Study
- 2009
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Ingår i: Clinical anatomy (New York, N.Y. Print). - : Wiley. - 0897-3806 .- 1098-2353. ; 22:4, s. 456-462
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to develop a software program, called Landmarker, which would aid studies of complex anatomical morphometry by simplifying the manual identification of landmarks in 3D images. We also tested its precision on routine magnetic resonance imaging (MRI) scans. To understand human biological variation, there is a need to identify morphological characteristics from the exterior and the interior of human anatomy. MRI, as opposed to other radiographic methods (mainly based on X-ray techniques), supplies good soft tissue contrast, which allows for more complex assessments than what bony landmarks can provide. Because automation of this assessment is highly demanding, one of the primary goals for the new software was to enable more rapid identification of landmark sets in 3D image data. Repeat acquisition of head MRIs having a resolution of 0.94 x 0.94 x 1.20 mm3 were performed on 10 volunteers. Intra- and interoperator, as well as interacquisition variations of manual identification of exterior, craniofacial interior, and brain landmarks were studied. The average distances between landmarks were <1.8 mm, <2.3 mm, and <2.0 mm in the intra- and interoperator, and interacquisition evaluations, respectively. This study presents new software for time efficient identification of complex craniofacial landmarks in 3D MRI. To the best of our knowledge, no evaluation of software for rapid landmark-based analysis of complex anatomies from 3D MR data has yet been presented. This software may also be useful for studies in other anatomical regions and for other types of image data.
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| 8. |
- Forsberg, Christer, et al.
(författare)
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Principle, calibration, and application of the in situ alkali chloride monitor
- 2009
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Ingår i: Review of Scientific Instruments. - : American Institute of Physics. - 0034-6748 .- 1089-7623. ; 80:2, s. 023104-1-023104-4
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Tidskriftsartikel (refereegranskat)abstract
- The extended use of biomass for heat and power production has caused increased operational problems with fouling and high-temperature corrosion in boilers. These problems are mainly related to the presence of alkali chlorides (KCl and NaCl) at high concentrations in the flue gas. The In-Situ Alkali Chloride Monitor (IACM) was developed by Vattenfall Research and Development AB for measuring the alkali chloride concentration in hot flue gases (>650 oC). The measurement technique is based on molecular differential absorption spectroscopy in the UV range. Simultaneous measurement of SO2 concentration is also possible. The measuring range is 1-50 ppm for the sum of KCl and NaCl concentrations, and 4-750 ppm for SO2. This paper describes the principle of the IACM as well as its calibration. Furthermore, an example of its application in an industrial boiler is given.
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