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- Beyer, K., et al.
(author)
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Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers
- 2000
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In: Journal of Investigative Dermatology. - : Elsevier BV. - 0022-202X .- 1523-1747. ; 115:5, s. 906-908
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Journal article (peer-reviewed)abstract
- Atopic dermatitis is a chronic inflammatory skin disease that affects 10-20% of the population. Linkage of atopy, asthma, allergic rhinitis, and total serum IgE levels to several different chromosomal regions have been described extensively, but little is known about the genetic control of atopic dermatitis. We tested for the association and linkage between atopic dermatitis and five chromosomal regions: 5q31-33, 6p21.3, 12q15-24.1, 13q12-31, and 14q11.2/14q32.1-32.3. Marker analysis was performed in two Caucasian populations: (i) 192 unrelated German children with atopic dermatitis and 59 non-atopic children from a German birth cohort study (MAS '90), parental DNA was tested in 77 of 192 children with atopic dermatitis, (ii) 40 Swedish families with at least one family member with atopic dermatitis selected from the International Study of Asthma and Allergy in Children. Evidence for linkage and allelic association for atopic dermatitis was observed for markers on chromosome 13q12-14 and 5q31-33.
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- Hjelm, Johan, et al.
(author)
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Electropolymerisation dynamics of a highly conducting metallopolymer : poly-[Os(4′-(5-(2,2′-bithienyl))-2,2′:6′,2″-terpyridine)2]2
- 2004
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In: Electrochemistry communications. - : Elsevier BV. - 1388-2481 .- 1873-1902. ; 6:2, s. 193-200
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Journal article (other academic/artistic)abstract
- The potential, time, and concentration dependence of the potentiostatic electropolymerisation of the thienyl-substituted transition metal complex [Os(bttpy)22+] onto platinum disk microelectrodes is reported, bttpy is 4′-(5-(2,2′-bithienyl))-2,2′:6′,2″-terpyridine. Oxidative electropolymerisation of the thienyl bridges is highly efficient with an electropolymerisation efficiency of 36 ± 3% being observed across a wide range of potentials and monomer concentrations. The osmium centres are oxidised when polymerisation proceeds and the deposited polymer is highly conducting allowing high surface coverage films, up to 6 × 10−7 mol cm−2, to be deposited within 60 s. SEM imaging reveals that smooth films can be produced using moderate overpotentials for electrodeposition. Significantly, diffusional mass transport controls the rate of film deposition allowing the radial diffusion field found at microelectrodes to be exploited to favour film growth co-planar with the electrode surface. The electropolymerisation rate increases approximately linearly with increasing monomer concentration from approximately 8 to 400 μM and this first-order dependence likely arises from mass transport limitations. The rate of homogeneous charge transport through potentiostatically deposited films, characterised by D1/2C, where D is the apparent charge transport diffusion coefficient and C is the concentration of osmium centres, is 3.5 ± 0.5 × 10−7 mol cm−2 s−1/2 and is largely insensitive to the deposition potential, and is very similar to that previously observed for potentiodynamically deposited films. This charge transport parameter is approximately two orders of magnitude larger than those found for non-conjugated bridges and is interpreted in terms of resonant superexchange across the quaterthienyl bridge.
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