Sökning: WFRF:(Francisco Liton)
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Late morbidity and ...
Late morbidity and mortality after autologous blood or marrow transplantation for lymphoma in children, adolescents and young adults—a BMTSS report
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- Holmqvist, Anna Sällfors (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Meng, Qingrui (författare)
- University of Alabama at Birmingham School of Medicine
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- Dai, Chen (författare)
- University of Alabama at Birmingham School of Medicine
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- Hageman, Lindsey (författare)
- University of Alabama at Birmingham School of Medicine
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- Landier, Wendy (författare)
- University of Alabama at Birmingham School of Medicine
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- Wu, Jessica (författare)
- University of Alabama at Birmingham School of Medicine
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- Francisco, Liton F. (författare)
- University of Alabama at Birmingham School of Medicine
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- Ross, Elizabeth Schlichting (författare)
- University of Alabama at Birmingham School of Medicine
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- Balas, Nora (författare)
- University of Alabama at Birmingham School of Medicine
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- Bosworth, Alysia (författare)
- City of Hope National Medical Center
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- Te, Hok Sreng (författare)
- University of Minnesota
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- Bhatia, Ravi (författare)
- University of Alabama
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- Rosenthal, Joseph (författare)
- City of Hope National Medical Center
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- Wong, F. Lennie (författare)
- City of Hope National Medical Center
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- Weisdorf, Daniel (författare)
- University of Minnesota
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- Armenian, Saro H. (författare)
- City of Hope National Medical Center
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- Bhatia, Smita (författare)
- University of Alabama at Birmingham School of Medicine,University of Alabama
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(creator_code:org_t)
- 2024
- 2024
- Engelska 9 s.
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Ingår i: Leukemia. - 0887-6924. ; 38:3, s. 601-609
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We determined the risk of late morbidity and mortality after autologous blood or marrow transplantation (BMT) for lymphoma performed before age 40. The cohort included autologous BMT recipients who had survived ≥2 years after transplantation (N = 583 [HL = 59.9%; NHL = 40.1%]) and a comparison cohort (N = 1070). Participants self-reported sociodemographics and chronic health conditions. A severity score (grade 3 [severe], 4 [life threatening] or 5 [fatal]) was assigned to the conditions using CTCAE v5.0. Logistic regression estimated the odds of grade 3–4 conditions in survivors vs. comparison subjects. Proportional subdistribution hazards models identified predictors of grade 3–5 conditions among BMT recipients. Median age at BMT was 30.0 years (range: 2.0–40.0) and median follow-up was 9.8 years (2.0–32.1). Survivors were at a 3-fold higher adjusted odds for grade 3–4 conditions (95% CI = 2.3–4.1) vs. comparison subjects. Factors associated with grade 3–5 conditions among BMT recipients included age at BMT (>30 years: adjusted hazard ratio [aHR] = 2.31; 95% CI = 1.27–4.19; reference: ≤21 years), pre-BMT radiation (aHR = 1.52; 95% CI = 1.13–2.03; reference: non-irradiated), and year of BMT (≥2000: aHR = 0.54; 95% CI = 0.34–0.85; reference: <1990). The 25 years cumulative incidence of relapse-related and non-relapse-related mortality was 18.2% and 25.9%, respectively. The high risk for late morbidity and mortality after autologous BMT for lymphoma performed at age <40 calls for long-term anticipatory risk-based follow-up.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Leukemia
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Holmqvist, Anna ...
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Meng, Qingrui
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Dai, Chen
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Hageman, Lindsey
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Landier, Wendy
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Wu, Jessica
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Francisco, Liton ...
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Ross, Elizabeth ...
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Balas, Nora
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Bosworth, Alysia
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Te, Hok Sreng
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Bhatia, Ravi
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Rosenthal, Josep ...
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Wong, F. Lennie
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Weisdorf, Daniel
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Armenian, Saro H ...
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Bhatia, Smita
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