| 1. |
- Aspenström, Pontus, et al.
(författare)
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Pombe Cdc15 homology proteins : regulators of membrane dynamics and the actin cytoskeleton
- 2006
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Ingår i: TIBS -Trends in Biochemical Sciences. Regular ed.. - : Elsevier BV. - 0968-0004 .- 1362-4326. ; 31:12, s. 670-679
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Forskningsöversikt (refereegranskat)abstract
- Pombe Cdc15 homology (PCH) proteins have emerged in many species as important coordinators of signalling pathways that regulate actomyosin assembly and membrane dynamics. For example, the prototype PCH protein, Cdc15p of Schizosaccharomyces pombe, has a role in assembly of the contractile ring, which is needed to separate dividing cells. Recently, mammalian PCH proteins have been found to bind phospholipids and to participate in membrane deformation. These findings suggest that PCH proteins are crucial linkers of membrane dynamics and actin polymerization, for example, during the internalization of transmembrane receptors. Intriguingly, some members of the PCH protein family are mutated in neurodegenerative and inflammatory diseases, which has implications for the identification of cures for such disorders.
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| 2. |
- Axelsson, Magnus, 1974, et al.
(författare)
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Design criteria for permeation grouting in hard rock at great depths
- 2008
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Ingår i: Proceedings World Tunnel Congress 2008, Underground facilities for better environmnet and saftey. ; 1, s. 510-520
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Tidskriftsartikel (refereegranskat)abstract
- Grouting at tunnelling in hard rock at great depths below the groundwater table, when constructing a nuclear waste repository for example, makes special demands on the strength of the grout in order to resist groundwater forces. The aim of this study is to distinguish the most important parameters to ensure that suitable grouting can be performed at large depths. Initially, laboratory studies were conducted in order to determine the most critical parameters. The results from the laboratory tests were used in a field study at the Äspö Hard Rock Laboratory in Sweden. The results indicate that the most important characteristics for the rock are the fracture aperture and the groundwater gradient and for the grout: a resolute grouting pressure and sufficient early strength. This implies that for cementitious grouts the yield stress is important and for non-cementitious grouts it is the shear strength prior to gelling. The results emphasise the need to perform hydraulic characterisation of the rock mass in advance. The results also show the importance of performing a proper grouting, especially at large depths where a decreased penetration length of the grout increases the risk of a high gradient and hence erosion of the grout.
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| 3. |
- Axelsson, Magnus, 1974, et al.
(författare)
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Stop mechanism for cementitious grouts at different water-to-cement ratios
- 2009
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Ingår i: Tunnelling and Underground Space Technology. - : Elsevier BV. - 0886-7798. ; 24:4, s. 390-397
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Tidskriftsartikel (refereegranskat)abstract
- Cementitious grouts are the most commonly used grouting material in the world. The general concept of grouting is to propagate the grout in a sufficiently large volume in the grouted medium and hence to have a controlled penetration. This study has been performed in order to determine and test the different mechanisms that result in stoppage of the penetration of cementitious grouts. This is performed as sand column tests in a laboratory study, coupled with grouting in the field. The result shows that three different stop mechanisms can be identified depending on the ratio between the grain size of the grout and the available opening. At an opening up to three times the size of the largest grout grains, penetration does not occur due to clogging of the grains. For an opening larger than five times the largest grain the penetration is unrestricted and stoppage occurs due to equilibrium between the driving and resistance forces. Between these ratios, a transition area exists where the water content determines the penetrability and the stoppage is governed by a filtration process for the grout grains. This implies that grouting with higher water-to-cement ratios results in a larger penetration area and hence by applying the mixture-thickening method during grouting an increased sealing efficiency can be obtained. (c) 2008 Elsevier Ltd. All rights reserved.
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| 4. |
- Benson, Mikael, 1954, et al.
(författare)
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Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen-challenged patients with intermittent allergic rhinitis.
- 2007
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Ingår i: Allergy. - : Wiley. - 0105-4538 .- 1398-9995. ; 62:2, s. 178-83
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Decreased levels of the anti-inflammatory Clara Cell Protein 16 (CC16) are found in intermittent allergic rhinitis (IAR) and asthma. In asthma this decrease has been associated with hyperreactivity and the A38G single nucleotide polymorphism (SNP). The aim of this study was to examine if IAR is associated with signs and symptoms of rhinitis and the A38G SNP. METHODS: Nasal fluid CC16 was analyzed in 20 patients with IAR before allergen challenge and 1 and 6 h after challenge, and from 28 healthy controls. The A38G SNP was analyzed in 80 patients with IAR and 106 controls. Nasal biopsies were obtained from three subjects in each group for immunohistochemical analysis of CC16. RESULTS: In the allergen-challenged patients symptoms and rhinoscopic signs of rhinitis increased after 1 h and normalized after 6 h. In contrast, nasal fluid CC16 decreased 1 h after allergen challenge and returned to baseline after 6 h. Nasal fluid CC16 levels did not differ from controls before and 6 h after challenge. Immunohistochemical investigation showed intense CC16 staining in the nasal epithelium of both patients before season and healthy controls, but weak staining in symptomatic patients during season. No significant association between the A38G SNP and IAR was found. CONCLUSION: There was an inverse relation between nasal fluid CC16 levels and symptoms and signs of rhinitis in allergen-challenged patients with IAR. However, there was no association between IAR and the A38G SNP.
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| 5. |
- Bråmå, Åsa, 1963-
(författare)
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Studies in the Dynamics of Residential Segregation
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In four scientific papers, this thesis investigates the processes, in terms of movements of individuals, that have produced, reproduced and transformed patterns of residential segregation in Swedish cities between 1990 and 2000.Paper 1 examines processes of immigrant concentration, and the role of the Swedish majority population in these processes. Neighbourhood transition and mobility are described and analysed for a selection of residential areas that have experienced increased immigrant concentration. The results show that low in-migration rate among Swedes, rather than high out-migration rate, has been the main driving force behind the production and reproduction of immigrant concentration areas.Paper 2 investigates the hypothesis that distressed neighbourhoods retain their character of distress through selective migration. The socio-economic situations of in-migrants, out-migrants and stayers in the distressed neighbourhoods of Stockholm are analysed and compared, and the results show the hypothesis to be confirmed. The people who move in are more likely to be unemployed and dependent on social benefits, and have on average lower incomes than those who move out and those who remain in the neighbourhoods. Paper 3 further investigates the selective character of the out-migration from distressed neighbourhoods. One important conclusion is that the out-migration flow from the distressed residential areas is socio-economically and ethnically selective. When demographic and socio-economic differences are controlled for, the likelihood of leaving the distressed neighbourhoods is much lower for an immigrant than for a Swedish-born person.Paper 4 examines the migration flows of a whole city, Göteborg. The paper deals with some of the most common questions within segregation research; the degree of spatial concentration of different ethnic groups, processes of concentration and dispersal, the role of the minority enclaves as ports of entry to the local housing market, and how this differs between ethnic groups.
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| 6. |
- Eriksson, Magnus, et al.
(författare)
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Grouting trials in hard jointed rock-investigation, design and execution
- 2005
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Ingår i: Proceedings of the 16th International Conference on Soil Mechanics and Geotechnical Engineering, Vols 1-5. - 9789059660274 ; , s. 2247-2251
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Konferensbidrag (refereegranskat)abstract
- Grouting trials were performed in crystalline rock at a depth of 450 m during construction of a 70-metre long tunnel. Hydrogeological investigations were undertaken stepwise, resulting in a successive updating of the rock description, followed by grouting design, and prognoses. The application of this coupled methodology for rock characterisation and design meant that, (a) general systematic pre-grouting could be avoided thanks to having detailed rock characterisation, and (b) an early assessment could be made about the most suitable grouting methodology. The initial description of rock, based on data obtained from a core borehole, was used to prepare a base design, and two grouting fans were anticipated. Even though further investigations resulted in design changes along a section of the tunnel, a combination of inflow measurements and pressure build-up tests gave a sound basis from which to choose the appropriate grout, and prepare for encountering more extreme conditions. Based on inflow measurements, the seating effect for Fans I and 2 was approximately 99.9 and 95 per cent respectively.
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| 7. |
- Fransson, Göran, et al.
(författare)
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Baklänges in i framtiden
- 2005
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Ingår i: Pedagogiska magasinet. - 1401-3320. ; :1, s. 28-33
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Att tala om framtidens lärare är inte bara ett sätt att konstruera möjliga framtidsbilder. Talet om framtiden kan även ses om ett sätt att påverka och styra människor. Detta eftersom man rimligen förväntas förbereda sig för den framtid som målas upp. Är det inte så att exempelvis talet om flexibla medarbetare gör att vi lite till mans funderar över hur vi skall agera och över vilka kunskaper eller förhållningssätt som vi behöver utveckla för att betraktas som flexibla? När vi sedan hamnar i situationer där det ställs krav på flexibilitet, är vi redan mentalt förberedda på det och ser inte det som något konstigt. Talet om framtiden och framtidens lärare kan alltså ses som ett sätt att påverka betingelser och människor, att skapa en viss form av mentalitet som styr och påverkar oss att till exempel förstå något på ett visst sätt eller att göra viss val. Begreppet styrningsmentalitet används i detta sammanhang för att beteckna de strategier och tekniker som används för att utveckla, formulera och styra människors handlingar och tankar (Popkewitz, 1998).
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