| 1. |
- Abdul Hamid, Akram, et al.
(författare)
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The impact of a DCV-system on the IAQ, energy use, and moisture safety in apartments - a case study
- 2022
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Ingår i: International Journal of Ventilation. - : Informa UK Limited. - 1473-3315 .- 2044-4044. ; 21:1, s. 35-52
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Tidskriftsartikel (refereegranskat)abstract
- A novel DCV-system controls the air-change rate for each apartment in multifamily buildings based on two indoor air parameters: 1) the moisture load (supply), and 2) volatile organic compounds. With a central fan, but decentralized control boxes placed outside each apartment, the system controls the air-change rate for each apartment. This paper’s main aim is to determine the potential of this DCV-system, through a case study, to: 1) achieve good IAQ, 2) handle the moisture loads appropriately, and 3) achieve good energy efficiency in multifamily buildings. Furthermore, the paper aims to assess the possibility to achieve good IAQ by validating the DCV-system’s VOC-controls through measurements of CO2 in apartments. Field measurements show that the system responds appropriately to apartment-specific loads, and that acceptable emission and moisture loads are achieved in most apartments in the case study. The impact that the system has on the energy use was assessed through calculations based on the field measurements. The calculations show that the DCV-system saves energy used for heating the supply-air by 86% in comparison to a mechanically balanced ventilation system without heat recovery, and 22% in comparison to the same system but with heat recovery.
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| 2. |
- Bränn, Emma, et al.
(författare)
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Inflammatory markers in women with postpartum depressive symptoms
- 2020
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Ingår i: Journal of Neuroscience Research. - : Wiley. - 0360-4012 .- 1097-4547. ; 98:7, s. 1309-1321
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Tidskriftsartikel (refereegranskat)abstract
- Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in perinatal depression is not as well studied. The aim of this study was to investigate the alterations in peripheral levels of inflammatory biomarkers in 169 Swedish women with and without depressive symptoms according to the Edinburgh postnatal depression scale or the M.I.N.I neuropsychiatric interview at eight weeks postpartum. Among the 70 markers analyzed with multiplex proximity extension assay, five were significantly elevated in women with postpartum depressive symptoms in the adjusted LASSO logistic regression analysis: Tumor necrosis factor ligand superfamily member (TRANCE) (OR-per 1 SD increase = 1.20), Hepatocyte growth factor (HGF) (OR = 1.17) Interleukin (IL)-18 (OR = 1.06), Fibroblast growth factor 23 (FGF-23) (OR = 1.25), and C-X-C motif chemokine 1 (CXCL1) (OR 1.11). These results indicate that women with PPD have elevated levels of some inflammatory biomarkers. It is, therefore, plausible that PPD is associated with a compromised adaptability of the immune system.
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| 3. |
- Doering, Sabrina, et al.
(författare)
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Anxiety symptoms preceding suicide: A Swedish nationwide record review.
- 2024
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Ingår i: Journal of Affective Disorders. - 0165-0327 .- 1573-2517. ; 355, s. 317-324
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Tidskriftsartikel (refereegranskat)abstract
- The literature on the relationship between anxiety and suicidal behaviors is limited and findings are mixed. This study sought to determine whether physicians noted anxiety symptoms and suicidality in their patients in the weeks and months before suicide.Data were derived from a nationwide medical record review of confirmed suicides in Sweden in 2015. Individuals with at least one documented physician consultation in any health care setting during 12months before suicide (N=956) were included. Clinical characteristics were compared between decedents with and without a notation of anxiety symptoms. Odds ratios were calculated to estimate associations between anxiety symptoms and suicidality in relation to suicide proximity.Anxiety symptoms were noted in half of individuals 1week before suicide. Patients with anxiety were characterized by high rates of depressive symptoms, ongoing substance use issues, sleeping difficulties, and fatigue. After adjustment for mood disorders, the odds of having a notation of elevated suicide risk 1week before death were doubled in persons with anxiety symptoms. Associations were similar across time periods (12months - 1week). Two-thirds had been prescribed antidepressants at time of death.Data were based on physicians' notations which likely resulted in underreporting of anxiety depending on medical specialty. Records were not available for all decedents.Anxiety symptoms were common in the final week before suicide and were accompanied by increases in documented elevated suicide risk. Our findings can inform psychiatrists, non-psychiatric specialists, and GPs who meet and assess persons with anxiety symptoms.
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| 4. |
- Fransson, Åsa, 1971, et al.
(författare)
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Bentonite rock interaction experiment: A hydro-structural-mechanical approach
- 2021
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Ingår i: Engineering Geology. - : Elsevier BV. - 0013-7952. ; 281
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Tidskriftsartikel (refereegranskat)abstract
- Deformation zones and fractures are of major importance to engineering and to the characterisation of the mechanical- and hydraulic behaviour of rock. In this paper we demonstrate how structural mapping can provide key information on fracture sets and their properties, and how it can be used to investigate conformity between different working scales. This is shown by the detailed structural mapping related to the experiment "BRIE" - Bentonite Rock Interaction Experiment. "BRIE" was carried out in a tunnel of the Aspo Hard Rock Laboratory, Sweden, in crystalline rock. The implemented approach relied on a multidisciplinary and trans-stadial investigation to compile and interpret all the hydrogeological, structural and rock mechanical constraints as inputs to modelling. To this end, available data from all BRIE construction- and experimental stages were used to characterise natural and induced rock stresses. Results from detailed structural mapping of the tunnel and drill cores recovered from the tunnel floor were key for sound rock mechanical modelling and were successfully integrated with the available hydrogeological observations. Structural mapping was used to define five systematic fracture sets, key fractures and their properties (size, friction angle and normal stiffness) and to establish a simple deformation history. Furthermore, the structural features exposed in the studied tunnel and in the logged BRIE cores were compared with those of an adjacent Aspo HRL tunnel. Both sites structurally fit the sub regional tectonic framework, thus showing conformity between very different observation scales.
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| 5. |
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| 7. |
- Hedlund, Katarina, et al.
(författare)
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Utmaningar och möjligheter
- 2022
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Ingår i: Markanvändning för en klimatpositiv framtid : En rapport om utmaningar och möjligheter i Skåne - En rapport om utmaningar och möjligheter i Skåne. - 9789198434996 - 9789198434989 ; , s. 48-60
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Johansson, Birgitta, 1959-, et al.
(författare)
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The effect of internet-administered support (carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer compared with support as usual: a study protocol for a randomized controlled trial.
- 2024
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Ingår i: BMC cancer. - 1471-2407. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- Informal caregivers (ICs) of patients with cancer provide essential and mainly uncompensated care. A self-perceived preparedness to care for the patient is associated with a lower caregiver burden, described as the extent to which caregiving is perceived as having adverse effects on IC functioning and well-being. ICs' well-being is associated with patient-perceived quality of care, suggesting that interventions to optimize ICs' health are essential in order to improve patient care. Head and neck cancer (HNC) is the seventh most common malignant disease in the world. The disease and its treatment have a significant negative impact on the patient's health and quality of life. Symptoms usually interfere with swallowing, food and fluid intake, breathing, speaking, and communication. ICs frequently manage patients' symptoms and side effects, especially problems related to nutrition and oral pain, without being properly prepared. Carer eSupport is an Internet-administered intervention, based on focus group discussions with ICs, developed in collaboration with ICs and healthcare professionals, tested for feasibility, and deemed feasible. This study protocol outlines the methods of investigating the effects of Carer eSupport plus support as usual (SAU) on self-reported preparedness for caregiving, caregiver burden, and well-being in the ICs of patients with HNC, compared with ICs receiving SAU only.In this randomized controlled trial, 110 ICs of patients with HNC, undergoing radiotherapy combined with surgery and/or medical oncological treatment, will be randomized (1:1) to Carer eSupport plus SAU or SAU only. Data will be collected at baseline (before randomization), post-intervention (after 18 weeks), and 3 months after post-intervention. The primary outcome is self-reported preparedness for caregiving. Secondary outcomes are self-reported caregiver burden, anxiety, depression, and health-related quality of life. The effect of Carer eSupport plus SAU on preparedness for caregiving and secondary outcomes, compared with SAU only, will be evaluated by intention to treat analyses using linear regression models, mixed-model regression, or analysis of covariance.If proven effective, Carer eSupport has the potential to significantly improve ICs' preparedness for caregiving and their wellbeing, thereby improving patient-perceived quality of care and patient wellbeing.ClinicalTrials.gov; NCT06307418, registered 12.03.2024 (https://clinicaltrials.gov/search? term=NCT06307418).
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| 9. |
- Kunovac Kallak, Theodora, 1985-, et al.
(författare)
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DNA methylation in cord blood in association with prenatal depressive symptoms
- 2021
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Ingår i: Clinical Epigenetics. - : BioMed Central (BMC). - 1868-7083 .- 1868-7075. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Prenatal symptoms of depression (PND) and anxiety affect up to every third pregnancy. Children of mothers with mental health problems are at higher risk of developmental problems, possibly through epigenetic mechanisms together with other factors such as genetic and environmental. We investigated DNA methylation in cord blood in relation to PND, taking into consideration a history of depression, co-morbidity with anxiety and selective serotonin reuptake inhibitors (SSRI) use, and stratified by sex of the child. Mothers (N = 373) prospectively filled out web-based questionnaires regarding mood symptoms and SSRI use throughout pregnancy. Cord blood was collected at birth and DNA methylation was measured using Illumina MethylationEPIC array at 850 000 CpG sites throughout the genome. Differentially methylated regions were identified using Kruskal-Wallis test, and Benjamini-Hochberg adjusted p-values < 0.05 were considered significant.Results: No differential DNA methylation was associated with PND alone; however, differential DNA methylation was observed in children exposed to comorbid PND with anxiety symptoms compared with healthy controls in ABCF1 (log twofold change - 0.2), but not after stratification by sex of the child. DNA methylation in children exposed to PND without SSRI treatment and healthy controls both differed in comparison with SSRI exposed children at several sites and regions, among which hypomethylation was observed in CpGs in the promoter region of CRBN (log2 fold change - 0.57), involved in brain development, and hypermethylation in MDFIC (log2 fold change 0.45), associated with the glucocorticoid stress response.Conclusion: Although it is not possible to assess if these methylation differences are due to SSRI treatment itself or to more severe depression, our findings add on to existing knowledge that there might be different biological consequences for the child depending on whether maternal PND was treated with SSRIs or not.
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| 10. |
- Ode Sang, Åsa, et al.
(författare)
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Planning, Designing, and Managing Green Roofs and Green Walls for Public Health : An Ecosystem Services Approach
- 2022
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Ingår i: Frontiers in Ecology and Evolution. - : Frontiers Media S.A.. - 2296-701X. ; 10
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Forskningsöversikt (refereegranskat)abstract
- Installing green roofs and green walls in urban areas is suggested to supply multiple ecosystem services of benefit to human health and well-being. In a three-step literature review, we examined current knowledge on the link between public health and green roofs and green walls. A systematic search identified 69 scientific articles on green roofs/walls with a public health discourse. These articles were categorized according to type of health path covered (reduction of temperature, air pollution, noise or environmental appraisal) and coverage of issues of relevance for strategies on planning, design/construction, and maintenance of green roofs and green walls. Articles identified through the structured search were complemented with reviews (with no explicit public health rationale) covering reduction of noise, temperature, or air pollution and environmental appraisal. Other relevant studies were identified through snowballing. Several of the articles provided guidelines for optimizing the effect of green roofs/walls in supporting ecosystem services and maximizing well-being benefits to support health pathways identified. These included specifications about planning issues, with recommended spatial allocation (locations where people live, sun-exposed for maximum ambient temperature reduction) and with physical access needed for environmental appraisal. Recommendations regarding design parameters covered substrate depth (deeper generally being better), plant choices (more diverse roofs providing more services), and maintenance issues (moist substrate positively correlated with heat reduction).
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