| 1. |
- Dunham, I, et al.
(författare)
-
The DNA sequence of human chromosome 22
- 1999
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
|
|
| 3. |
- Kedra, D, et al.
(författare)
-
Characterization of the human synaptogyrin gene family.
- 1998
-
Ingår i: Human Genetics. - : Springer Science and Business Media LLC. - 0340-6717 .- 1432-1203. ; 103:2, s. 131-41
-
Tidskriftsartikel (refereegranskat)abstract
- Genomic sequencing was combined with searches of databases for identification of active genes on human chromosome 22. A cosmid from 22q13, located in the telomeric vicinity of the PDGFB (platelet-derived growth factor B-chain) gene, was fully sequenced. Using an expressed sequence tag-based approach we characterized human (SYNGR1) and mouse (Syngr1) orthologs of the previously cloned rat synaptogyrin gene (RATSYNGR1). The human SYNGR1 gene reveals three (SYNGR1a, SYNGR1b, SYNGR1c) alternative transcript forms of 4.5, 1.3 and 0.9 kb, respectively. The transcription of SYNGR1 starts from two different promoters, and leads to predicted proteins with different N- and C-terminal ends. The most abundant SYNGR1 a transcript, the 4.5-kb form, which corresponds to RATSYNGR1, is highly expressed in neurons of the central nervous system and at much lower levels in other tissues, as determined by in situ hybridization histochemistry. The levels of SYNGR1b and SYNGR1c transcripts are low and limited to heart, skeletal muscle, ovary and fetal liver. We also characterized two additional members of this novel synaptogyrin gene family in human (SYNGR2 and SYNGR3), and one in mouse (Syngr2). The human SYNGR2 gene transcript of 1.6 kb is expressed at high levels in all tissues, except brain. The 2.2-kb SYNGR3 transcript was detected in brain and placenta only. The human SYNGR2 and SYNGR3 genes were mapped by fluorescence in situ hybridization to 17qtel and 16ptel, respectively. The human SYNGR2 gene has a processed pseudogene localized in 15q11. All predicted synaptogyrin proteins contain four strongly conserved transmembrane domains, which is consistent with the M-shaped topology. The C-terminal polypeptide ends are variable in length, display a low degree of sequence similarity between family members, and are therefore likely to convey the functional specificity of each protein.
|
|
| 4. |
|
|
| 5. |
- Andersson, M, et al.
(författare)
-
Isospin resolved double pion production at Celsius
- 1998
-
Ingår i: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. - 0587-4254. ; 29:11, s. 2963-2968
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Two-pion production close to threshold has been measured in dfd and p+d reactions at CELSIUS. The results are compared to results at higher energies.
|
|
| 6. |
- Andersson, M, et al.
(författare)
-
Study of the p+d -> He-3+2 pi reaction at Celsius
- 1998
-
Ingår i: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. - 0587-4254. ; 29:11, s. 2969-2971
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The exclusive p + d -->(3) He + 2 pi reaction has been studied at CELSIUS at a beam energy of 477 MeV. Preliminary results indicate that the two pions are created mainly in an isospin T = 1 state.
|
|
| 7. |
- Berglund, Per, et al.
(författare)
-
Switched enantiopreference of Humicola lipase for 2-phenoxyalkanoic acid ester homologs can be rationalized by different substrate binding modes
- 1999
-
Ingår i: Tetrahedron. - 0957-4166 .- 1362-511X. ; 10:21, s. 4191-4202
-
Tidskriftsartikel (refereegranskat)abstract
- Humicola lanuginosa lipase was used for enantioselective hydrolyses of a series of homologous 2-phenoxyalkanoic acid ethyl esters. The enantioselectivity (E-value) of the enzyme changed from an (R)-enantiomer preference for the smallest substrate, 2-phenoxypropanoic acid ester, to an (S)-enantiomer preference for the homologous esters with longer acyl moieties. The E-values span the range from E=13 (R) to E=56 (S). A molecular modeling study identified two different substrate-binding modes for each enantiomer. We found that the enantiomers favored different modes. This discovery provided a model that offered a rational explanation for the observed switch in enantioselectivity. (C) 1999 Elsevier Science Ltd. All rights reserved.
|
|
| 8. |
- Bilger, R, et al.
(författare)
-
CELSIUS as an eta factory
- 1997
-
Ingår i: NUCLEAR PHYSICS A. - : ELSEVIER SCIENCE BV. - 0375-9474. ; 626:1-2, s. 93C-96C
-
Tidskriftsartikel (refereegranskat)abstract
- The WASA project at the CELSIUS storage ring is being prepared for high-luminosity experiments to study rare decays of light mesons, in particular the eta meson. The CELSIUS ring together with the newly developed pellet target will serve as an efficient e
|
|
| 9. |
- Bilger, R, et al.
(författare)
-
Two-pion production in proton-proton collisions near threshold at Celsius
- 1998
-
Ingår i: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. ; , s. 2987-2991
-
Konferensbidrag (refereegranskat)abstract
- Two-pion production reactions in proton-proton collisions near threshold are measured using an internal cluster-jet hydrogen target and the WASA/PROMICE detector at the CELSIUS storage ring. Four out of the five possible two-pion production reactions are
|
|
| 10. |
|
|
