| 1. |
- Calén, H., et al.
(författare)
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Deuteron breakup by 1.15 GeV protons and excitation of the Δ isobar
- 1993
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Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 303:1-2, s. 10-15
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Tidskriftsartikel (refereegranskat)abstract
- The pd→npp reaction has been measured using circulating 1.15 GeV protons, a gas jet target and scintillation detectors selecting scattered protons with energy above 30 MeV. The distribution of the two-proton invariant mass has a maximum at 2.13 ± 0.01 GeV/c2 and a width of 130 ± 10 MeV/c2 (FWHM). We see no evidence of narrow (Γ < 30 MeV/c2) peaks in the phase-space region selected. The mass of X, excited in the pN→nX elementary process, is 40 MeV/c2 smaller than the mass of a real Δ isobar.
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| 2. |
- Calén, H, et al.
(författare)
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Deuteron breakup in the Δ-isobar region
- 1993
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Ingår i: Physica Scripta. - : Institute of Physics (IOP). - 0031-8949 .- 1402-4896. ; 48:1, s. 86-91
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Tidskriftsartikel (refereegranskat)abstract
- The pd → npp charge exchange reaction has been studied at 1.15 GeV incident proton energy in a selected kinematical region. The distributions of two-proton invariant mass Mpp, of angle of a single proton and the differential cross section dσ/dt of the (p, n) reaction are presented and compared with model predictions corrected for the acceptance of the experimental apparatus. We see no evidence of narrow (Γ < 30 MeV/c2) peaks in the Mpp interval 2.1-2.3 GeV/c2. The production of an intermediate Δ isobar in the primary (p, n) charge exchange and its subsequent absorption in a final state ΔN → pp process together with the background from quasi-free charge exchange scattering reasonably reproduces the general trends of the data.
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| 3. |
- Fransson, L Å, et al.
(författare)
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Effects of cycloheximide, brefeldin A, suramin, heparin and primaquine on proteoglycan and glycosaminoglycan biosynthesis in human embryonic skin fibroblasts
- 1992
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Ingår i: Biochimica et Biophysica Acta. - 0006-3002. ; 1137:3, s. 287-297
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Tidskriftsartikel (refereegranskat)abstract
- (1) We have isolated radiolabelled proteoglycans and glycosaminoglycans produced by human embryonic skin fibroblasts in the presence of (a) cycloheximide to inhibit protein synthesis or (b) brefeldin A to impede transport between the endoplasmic reticulum and the Golgi complex or (c) suramin, heparin or primaquine to interfere with internalization, recycling and degradation. Effects on glycosaminoglycan synthesis were assayed separately by using exogenous p-nitrophenyl beta-D-xylopyranoside (and [3H]galactose) or 125I-labelled p-hydroxyphenyl beta-D-xylopyranoside as initiators. (2) Inhibition of protein synthesis or blocking of transport to the Golgi complex prevented production of most of the proteoglycans with one exception: Cell-associated heparan sulphate-proteoglycan was still produced at 20% of the control level. (3) Treatment with suramin or heparin resulted in decreased deposition of proteoglycan in the pericellular matrix but increased accumulation of cell-associated proteoglycan. Primaquine blocked all proteoglycan synthesis. (4) In the presence of cycloheximide, exogenous beta-D-xyloside initiated galactosaminoglycan production. In contrast, in brefeldin A-treated cells, synthesis was completely abolished. Not even formation of the linkage-region trisaccharide could be detected. (5) These results suggest that exogenous xyloside enters the endoplasmic reticulum and is subsequently transported to the trans-Golgi complex where all further steps involved in glycosaminoglycan assembly takes place. (6) Heparan sulphate proteoglycan produced by brefeldin A-treated cells could be derived from (a) an intracellular pool of preformed core protein located to the trans-Golgi complex, or (b) resident proteoglycan that was either deglycanated/reglycanated or chain-extended. As combined treatment with suramin and brefeldin A markedly reduced cell-associated proteoglycan production, the latter possibility is favoured.
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| 4. |
- Gustafsson, P. M., et al.
(författare)
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Gastro-oesophageal reflux and severity of pulmonary disease in cystic fibrosis
- 1991
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa Healthcare. - 0036-5521 .- 1502-7708. ; 26:5, s. 449-456
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Tidskriftsartikel (refereegranskat)abstract
- The correlation between oesophageal dysfunction (OD), pathologic gastro-oesophageal reflux (GOR), and severity of pulmonary disease was studied in 12 patients with cystic fibrosis (CF). They were interviewed about symptoms of OD and underwent 24-h pH recording in the oesophagus, oesophageal manometry combined with reflux provocation tests, the acid perfusion test, the acid clearance test, lung function tests, and scoring of the chest radiograph. Six of the 12 patients reported symptoms of OD. Abnormal GOR, as shown by 24-h pH monitoring of the oesophagus, was found in eight of them. Altogether 9 of the 12 participants had at least one pathologic oesophagus test result. Results of radiologic examinations of the oesophagus, performed in six patients, were pathologic. The four patients with the best chest radiograph scores and the best lung function had significantly less signs and symptoms of OD and GOR than the other eight patients. We conclude that OD, GOR, and pulmonary disease covariate in CF.
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