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- Cousins, Sara A. O., et al.
(författare)
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Reconstructing past land use and vegetation patterns using palaeogeographical and archaeological data : A focus on grasslands in Nynas by the Baltic Sea in south-eastern Sweden
- 2002
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Ingår i: Landscape and Urban Planning. - 0169-2046 .- 1872-6062. ; 61:1, s. 1-18
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Tidskriftsartikel (refereegranskat)abstract
- Past landscape characteristics were reconstructed in Nynas, south-eastern Sweden, using geographical and archaeological data together with pollen stratigraphy and an existing shore displacement model, with the aim to explore the development of semi-natural grasslands in the area. A 2.3 m peat core was analysed and radiocarbon dated at three levels. The pollen stratigraphy was estimated to start at approximately 3800 C-14 years before present (BP), at the end of Late Neolithic. Human activities are evident, from both archaeological findings and pollen analysis, for more than 4000 years. Grazing is apparent, possibly more intense around 3200 C-14 years BP, 2500-2600 C-14 years BP, 2100-2200 C-14 years BP, and 1300/1400 C-14 years BP to present day. From 1900+/-80 C-14 years BP and onwards cultivation is intensified at the same time as spruce (Picea abies) expands. Maps on land-cover distribution in the late 17th century was used as a model for the utilisation of the landscape during the Iron Age. Land-covers on very thin soils were grazed and sometimes mown within the village boundaries, but they were also used for cultivation in narrow strips where bedrock is adjacent to clays. Till and varved glacial clays would have been used for cultivation. A reasonable estimation is that 10% of the study area could have been used for cultivation 1900 C-14 years BP, compared to 28% in the end of the 17th century. During the last century there has been a shift towards more arable fields and more forestry. There are 10% open or semi-open grassland left today, and 6% wooded grassland, compared with 47% open or semi-open grassland in the 17th century. Little more than half of the open grasslands are managed today, all by grazing. It is argued that encroachment of trees and shrubs on open or semi-open grasslands will not only reduce species richness in the landscape but also threaten parts of our cultural heritage.
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- Höckerfelt, U, et al.
(författare)
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Early increase and later decrease in VIP and substance P nerve fiber densities following abdominal radiotherapy : a study on the human colon.
- 2002
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Ingår i: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 78:11, s. 1045-53
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The neuropeptides substance P (SP) and vasoactive intestinal peptide (VIP) mediate physiologic activities in the intestine, not least in relation to motility and inflammatory processes. Neuropeptides are up-regulated and play particular importance during tissue stress. This paper aims to quantify mucosal and smooth muscle SP, VIP and total innervation in human colon in short- and long-term perspectives after abdominal irradiation.MATERIALS AND METHODS: Colon specimens from 23 irradiated or non-irradiated patients were investigated with immunohistochemistry and computerized image analysis. Plasma levels of SP and VIP in 15 additional patients receiving radiotherapy were analyzed.RESULTS: At 4-7 days after irradiation (5 x 5 Gy), the overall innervation, and also VIP and SP nerve fiber densities, were increased in both mucosa and circular muscle layer. In contrast, 5-6 weeks as well as several years after irradiation, the VIP and SP nerve fiber densities were decreased. No peptide changes were revealed in plasma.CONCLUSIONS: The degree of VIP and SP intestinal innervation was increased after radiotherapy in the short-term perspective but it decreased in the long-term. In the short-term, SP may have pro-inflammatory and VIP anti-inflammatory effects and the peptides may have trophic effects and be related to the occurrence of motor changes. It cannot be excluded that the decrease in VIP and SP neuronal supply seen in the long-term may contribute to intestinal malfunction.
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- Tornblom, M, et al.
(författare)
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Lead time associated with screening for prostate cancer
- 2004
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136. ; 108:1, s. 122-129
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Tidskriftsartikel (refereegranskat)abstract
- Screening serum levels of prostate-specific antigen (PSA) is now a major strategy for early detection of prostate cancer (PC). Quantification of the lead time thus obtained is important both for understanding the development of PC and for evaluating the advantages and disadvantages of widespread screening. In our study, 1,233 randomly selected men living in Stockholm in 1988 were invited to participate in an early detection (ED) program, in which suspicious findings provided by digital rectal examination (DRE), transrectal ultrasonography (TRUS) and/or a PSA value greater than or equal to10.0 ng/mL were followed up by biopsy. The cumulative incidence (Kaplan-Meier) of PC in the 946 participants (ED) during 12 years of follow-up was compared to that of an age-matched, randomly selected reference population (RP) of 657 men for whom PSA values (from frozen serum samples) could also be obtained. The PC incidence in men in the RP with PSA values >3.0 ng/mL reached the corresponding level for the ED group after 10.6 years (the "catch-up" point). After 12 years of follow-up, the estimated median lead time for men with PSA values in this interval was 4.5 years in the ED population, compared to 7.8 years in the RP. With 20 years of follow-up, the estimated median lead time of the RP was enhanced to 10.7 years. The lead time in connection with PC was influenced by the initial PSA level (although with large variations), length of follow-up and sensitivity of the ED procedure employed. The ED program described here was not associated with major overdetection.
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