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- Carlsson, L G, et al.
(författare)
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Efficacy of cumulative doses of salbutamol administered via Turbuhaler or Diskhaler in patients with reversible airway obstruction
- 1998
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Ingår i: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 53:7, s. 712-715
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Tidskriftsartikel (refereegranskat)abstract
- The study aimed to estimate the relative dose potency of salbutamol inhaled via Turbuhaler and Diskhaler. The 24 adult patients participating had chronic reversible airway obstruction. The study was of a double-blind, double-dummy, crossover, randomized design. Five doses of salbutamol Turbuhaler, 50, 50, 100, 200, and 400 microg, were given on one study day at intervals of 30 min. On another study day, five doses of salbutamol Diskhaler, 200, 200, 400, 800, and 1600 microg, were given with the same interval. The treatment days were separated by a washout period of at least 24 h. The inhalation technique was standardized and supervised. Efficacy variables were recorded before and after each study dose. The primary efficacy variable was forced expiratory volume in 1 s (FEV1). When parallel and linear cumulative dose-response curves were statistically compared on a logarithmic scale, the dose potency of salbutamol Turbuhaler vs salbutamol Diskhaler was 1.99 (95% confidence interval 1.52-2.54). This study indicates that only half the dose of salbutamol is required via Turbuhaler as via Diskhaler for the same bronchodilating effect.
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- Drake, M., et al.
(författare)
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The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain
- 1996
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Ingår i: Acta Physiologica Scandinavica. - 0001-6772. ; 158:2, s. 155-159
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Tidskriftsartikel (refereegranskat)abstract
- The effect of the immunosuppressant FK506 on ischaemic neuronal damage was studied in a rat model of transient cerebral ischemia induced by occlusion of both common carotid arteries in combination with hypotension for 10 min. Neuronal damage was assessed morphologically after 4 days of recovery. Treatment with FK506, given at a dose of 2 mg kg-1 by intraperitoneal injections 30 min prior to ischemia and once daily during recovery, decreased neuronal damage by 52% in the hippocampal CA1 region and by 48% in the temporal cortex. The protection was not due to diminished body temperature or a marked reduction of ischaemia-induced synaptic overflow of glutamate. We propose that FK506 decreases neuronal damage either by inhibiting calcineurin-mediated events or by preserving mitochondrial function.
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- Ferrand-Drake, M., et al.
(författare)
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Mitochondrial permeability transition induced DNA-fragmentation in the rat hippocampus following hypoglycemia
- 1999
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Ingår i: Neuroscience. - 0306-4522. ; 90:4, s. 1325-1338
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Tidskriftsartikel (refereegranskat)abstract
- In the present study the time-course of DNA fragmentation following insulin-induced hypoglycemia was examined. In situ localization of DNA breaks were studied by the terminal deoxynucleotidyl transferase-mediated biotin- deoxyuridine triphosphate nick-end labelling method, and the temporal profile of DNA-fragmentation by agarose gel electrophoresis. Cell nuclei displayed terminal deoxynucleotidyl transferase-deoxyuridine triphosphate nick-end labelling within 3 h of recovery following 30 min of a hypoglycemic insult, and DNA from the hippocampus displayed oligonucleosomal fragmentation. Ultrastructural examination of the dentate granule cells showed mitochondrial swelling during the acute phase of the hypoglycemic insult, which preceded the DNA fragmentation seen in the recovery phase. Cyclosporin A but not tacrolimus, prevented mitochondrial swelling and subsequent DNA fragmentation. We conclude that during severe energy deprivation following hypoglycemia, mitochondrial swelling occurs due to mitochondrial permeability transition and that factors are released, which upon recovery can activate processes leading to DNA fragmentation and cell death.
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- Friberg, Bertil, 1950, et al.
(författare)
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Mk II: the self-tapping Brånemark implant: 5-year results of a prospective 3-center study.
- 1997
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Ingår i: Clinical oral implants research. - 0905-7161. ; 8:4, s. 279-85
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Tidskriftsartikel (refereegranskat)abstract
- The 5-year result of a prospective 3-center study is presented, comprising 103 patients with 288 Mk II self-tapping and 275 standard implants of the Brånemark System. Out of 363 mandibular and 200 maxillary fixtures, one Mk II was lost of the lower jaw and 13 of each implant type failed in maxillae during the study period. Cumulative prosthesis stability was 97%. Five patients accounted for more than 85% of the fixture losses. Marginal bone resorption was similar for both implant designs. Apart from the implant failures and one patient exhibiting disturbed nerve sensation of the mental nerve, no major complications were encountered. Overall, this study revealed equal cumulative success rates for standard and Mk II implants after 5 years of observation. Mandibular implants exhibited greater success rates (100%) for both tested implant types compared to maxillary implants (87%).
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