| 1. |
- Friman, Styrbjörn, 1948, et al.
(författare)
-
Hepatic clearance of polyethylene glycol 900 and mannitol in the pig.
- 1988
-
Ingår i: Digestion. - 0012-2823. ; 39:3, s. 172-80
-
Tidskriftsartikel (refereegranskat)abstract
- Fluid phase markers like erythritol and mannitol have been used to study canalicular bile secretion in the liver. It has recently been suggested that these molecules cross the ductular epithelium and thereby their biliary clearance may underestimate the canalicular bile flow. In the present study, the hepatic clearance of polyethylene glycol 900 (PEG 900), a fluid phase marker that has been used in studies of the kidney, was compared to the clearance of mannitol in the pig. We found that the hepatic clearance of PEG 900 exceeded that of mannitol by a factor of 55. After intravenous bolus injections, both mannitol and PEG 900 appeared within 1 min in bile while significant proportions of inulin were seen only after 7 min. The hepatic clearances of both mannitol and PEG 900 positively correlated to the bile acid secretion rate and were not affected by secretin infusion. The high hepatic clearance of PEG 900 compared to mannitol may be explained by a higher fluid flux into the canaliculi than previously estimated and a continuous ductular reabsorption of fluid and mannitol. Another possibility is an active transcellular vesicular transport of this molecule--an explanation that is not supported by the immediate appearance of PEG 900 in bile following an intravenous bolus injection nor by the finding that hepatic clearance of labeled PEG was not affected by a load of unlabeled marker.
|
|
| 2. |
- Friman, Styrbjörn, 1948, et al.
(författare)
-
Intussusception at four separate locations in the small intestine. Case report.
- 1988
-
Ingår i: Acta chirurgica Scandinavica. - 0001-5482. ; 154:7-8, s. 485-6
-
Tidskriftsartikel (refereegranskat)abstract
- A case of intussusception at four different locations in the small intestine is reported. Operative reduction of the interponates were performed with an uneventful postoperative course. The treatment of intussusception in adults is discussed and the literature is reviewed.
|
|
| 3. |
- Rådberg, Göran, 1945, et al.
(författare)
-
Enterohepatic bile-acid circulation in the pregnant cat.
- 1988
-
Ingår i: Acta physiologica Scandinavica. - 0001-6772. ; 133:1, s. 19-24
-
Tidskriftsartikel (refereegranskat)abstract
- Pregnancy increases the risk of gallstones. The physiological changes responsible for this are not clearly demonstrated. Adjustments in the enterohepatic circulation of bile acids have earlier been studied in pregnancy by methods involving dilution of labelled bile acids. In the present study the bile-acid circulation was measured with direct drainage methods in pregnant animals and controls. It was found that the total bile-acid-pool size was reduced to 65% in the pregnant cat (P less than 0.01) and there was a reduced accumulation of bile acids in the gallbladder after fasting 24 h (P less than 0.01). Bile-acid synthesis by the liver was not reduced and the relation between water and bile-acid secretion by the liver was unchanged. It is concluded that, in the pregnant cat, the bile-acid-pool size is reduced due to a decreased accumulation of bile acids in the gallbladder and an increased interdigestive recycling rate of the bile-acid pool (P less than 0.05). One possible explanation for the reduced accumulation of bile acids in the gallbladder is delayed emptying of the stomach, inducing a late refilling of the gallbladder after a meal.
|
|
| 4. |
- Rådberg, Göran, 1945, et al.
(författare)
-
Relationship between gallbladder histopathology and ability to concentrate biliary lipids and bilirubin. A study on gallstone patients with functioning gallbladder.
- 1988
-
Ingår i: Acta chirurgica Scandinavica. - 0001-5482. ; 154:10, s. 581-4
-
Tidskriftsartikel (refereegranskat)abstract
- Biliary lipids and bilirubin were measured in hepatic and gallbladder bile obtained at routine cholecystectomy in 35 gallstone patients. The gallbladders had opacified at cholecystography and the cystic ducts were patent at operation. The histologic changes in the gallbladder wall were evaluated by an independent pathologist. Increasing abnormality of the gallbladder wall was shown to be associated with reduced gallbladder contents/hepatic bile ratio of biliary lipids and of bilirubin. The concentrating function of the human gallbladder thus appears to be impaired in proportion to the severity of histologic lesions in its wall. Taken together with earlier findings in vitro, this relationship suggests impaired absorption of electrolytes and water by the gallbladder mucosa, or diffusion of biliary constituents from the lumen of the inflamed gallbladder.
|
|
