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Evaluation of the R...
Evaluation of the RSR 3 screen ICA™ and 2 screen ICA™ as screening assays for type 1 diabetes in Sweden
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- Törn, Carina (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Wallenberglaboratoriet, Malmö,Celiac Disease and Diabetes Unit,Lund University Research Groups,Faculty of Medicine,The Wallenberg Laboratory, Malmö
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- Vaziri-Sani, Fariba (författare)
- Lund University,Lunds universitet,LU Samverkan,Sektionen Forskning, samverkan och innovation,Universitetsförvaltningen,Universitetets ledning och förvaltning,Systemvirologi,Forskargrupper vid Lunds universitet,Cooperation office,Research, Collaboration and Innovation,Central Administration,University Management and Central Administration,Systems Virology,Lund University Research Groups
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- Ramelius, Anita (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Celiac Disease and Diabetes Unit,Lund University Research Groups,Faculty of Medicine
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- Elding Larsson, Helena (författare)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Paediatric Endocrinology,Lund University Research Groups,Faculty of Medicine
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- Ivarsson, Sten Anders (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Pediatrisk endokrinologi,Lund University Bioimaging Center,Medicinska fakulteten,Celiac Disease and Diabetes Unit,Lund University Research Groups,Paediatric Endocrinology,Faculty of Medicine
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- Amoroso, Marie (författare)
- RSR Limited
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- Furmaniak, Jadwiga (författare)
- RSR Limited
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- Powell, Michael (författare)
- RSR Limited
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- Smith, Bernard Rees (författare)
- RSR Limited
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(creator_code:org_t)
- 2022-02-26
- 2022
- Engelska.
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Ingår i: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 59:6, s. 773-781
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://link.springe...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aim: The study aim was to evaluate the RSR 3 Screen ICA™ and 2 Screen ICA™ for detection of islet cell autoimmunity in healthy Swedish subjects and patients with newly diagnosed type 1 diabetes (T1D). Methods: 3 Screen is designed for combined detection of autoantibodies to glutamic acid decarboxylase (GADA), to the islet antigen IA-2 (IA-2A) and to zinc transporter 8 (ZnT8A), while 2 Screen detects GADA and IA-2A. Serum samples from 100 T1D patients at onset and 200 healthy controls were studied. Results: 3 Screen achieved 93% assay sensitivity and 97.5% specificity, while 2 Screen achieved 91% assay sensitivity and 98.5% specificity. Samples were also tested in assays for individual autoantibodies. There was only one 3 Screen positive healthy control sample (0.5%) that was positive for multiple autoantibodies (IA-2A and ZnT8A). In contrast, most of the 93 3 Screen positive patients were positive for multiple autoantibodies with 72% (67/93) positive for both GADA and IA-2A and 57% (53/93) positive for three autoantibodies (GADA, IA-2A and ZnT8A). Insulin autoantibodies (IAA, measured by radioimmunoassay) were positive in 13 patients and two healthy controls. Conclusion: 3 Screen achieved high sensitivity and specificity, suitable for islet cell autoimmunity screening in a healthy population. In the case of 3 Screen positivity, further assays for GADA, IA-2A and ZnT8A are required to check for multiple autoantibody positivity, a hallmark for progression to T1D. In addition, testing for IAA in children below two years of age is warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- GADA
- IA-2A
- IAA
- Sensitivity
- Specificity
- ZnT8A
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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