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Proteomic Determina...
Proteomic Determinants of Variation in Cholesterol Efflux : Observations from the Dallas Heart Study
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- Gangwar, Anamika (författare)
- University of Texas Southwestern Medical Center
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- Deodhar, Sneha S. (författare)
- University of Texas Southwestern Medical Center
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- Saldanha, Suzanne (författare)
- University of Texas Southwestern Medical Center
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Abbasi, Fahim (författare)
- Stanford University School of Medicine
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- Pearce, Ryan W. (författare)
- Quest Diagnostics Cardiometabolic Center of Excellence
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- Collier, Timothy S. (författare)
- Quest Diagnostics Cardiometabolic Center of Excellence
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- McPhaul, Michael J. (författare)
- Quest Diagnostics
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- Furtado, Jeremy D. (författare)
- Biogen, Inc.
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- Sacks, Frank M. (författare)
- Harvard University
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- Merrill, Nathaniel J. (författare)
- Pacific Northwest National Laboratory
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- McDermott, Jason E. (författare)
- Pacific Northwest National Laboratory
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- Melchior, John T. (författare)
- University of Cincinnati,Oregon Health & Science University
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- Rohatgi, Anand (författare)
- University of Texas Southwestern Medical Center
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - 1661-6596. ; 24:21
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- High-density lipoproteins (HDLs) are promising targets for predicting and treating atherosclerotic cardiovascular disease (ASCVD), as they mediate removal of excess cholesterol from lipid-laden macrophages that accumulate in the vasculature. This functional property of HDLs, termed cholesterol efflux capacity (CEC), is inversely associated with ASCVD. HDLs are compositionally diverse, associating with >250 different proteins, but their relative contribution to CEC remains poorly understood. Our goal was to identify and define key HDL-associated proteins that modulate CEC in humans. The proteomic signature of plasma HDL was quantified in 36 individuals in the multi-ethnic population-based Dallas Heart Study (DHS) cohort that exhibited persistent extremely high (>=90th%) or extremely low CEC (<=10th%) over 15 years. Levels of apolipoprotein (Apo)A-I associated ApoC-II, ApoC-III, and ApoA-IV were differentially correlated with CEC in high (r = 0.49, 0.41, and −0.21 respectively) and low (r = −0.46, −0.41, and 0.66 respectively) CEC groups (p for heterogeneity (pHet) = 0.03, 0.04, and 0.003 respectively). Further, we observed that levels of ApoA-I with ApoC-III, complement C3 (CO3), ApoE, and plasminogen (PLMG) were inversely associated with CEC in individuals within the low CEC group (r = −0.11 to −0.25 for subspecies with these proteins vs. r = 0.58 to 0.65 for subspecies lacking these proteins; p < 0.05 for heterogeneity). These findings suggest that enrichment of specific proteins on HDLs and, thus, different subspecies of HDLs, differentially modulate the removal of cholesterol from the vasculature.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- apolipoprotein
- atherosclerotic cardiovascular disease
- cholesterol efflux capacity
- high-density lipoproteins (HDLs)
- proteomics
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Gangwar, Anamika
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Deodhar, Sneha S ...
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Saldanha, Suzann ...
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Melander, Olle
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Abbasi, Fahim
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Pearce, Ryan W.
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visa fler...
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Collier, Timothy ...
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McPhaul, Michael ...
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Furtado, Jeremy ...
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Sacks, Frank M.
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Merrill, Nathani ...
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McDermott, Jason ...
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Melchior, John T ...
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Rohatgi, Anand
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