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Stress-evoked tyros...
Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test
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- Ohnishi, Hiroshi (författare)
- Gunma University
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- Murata, Takaaki (författare)
- Gunma University, Gunma University Graduate School of Medicine
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- Kusakari, Shinya (författare)
- Gunma University
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- Hayashi, Yuriko (författare)
- Gunma University
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- Takao, Keizo (författare)
- Kyoto University Graduate School of Medicine, Fujita Health University
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- Maruyama, Toshi (författare)
- Gunma University
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- Ago, Yukio (författare)
- Osaka University
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Koda, Ken (författare)
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- Jin, Feng-Jie (författare)
- Gunma University
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- Okawa, Katsuya (författare)
- Kyowa Hakko Kirin Company Ltd., Takasaki
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- Oldenborg, Per-Arne (författare)
- Umeå universitet,Histologi med cellbiologi
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- Okazawa, Hideki (författare)
- Gunma University
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- Murata, Yoji (författare)
- Gunma University
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- Furuya, Nobuhiko (författare)
- Gunma University Graduate School of Medicine
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Matsuda, Toshio (författare)
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- Miyakawa, Tsuyoshi (författare)
- Kyoto University Graduate School of Medicine, Fujita Health University
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- Matozaki, Takashi (författare)
- Gunma University, Kobe University Graduate School of Medicine
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(creator_code:org_t)
- 2010
- 2010
- Engelska.
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Ingår i: Journal of Neuroscience. - 0270-6474 .- 1529-2401. ; 30:31, s. 10472-10483
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Severe stress induces changes in neuronal function that are implicated in stress-related disorders such as depression. The molecular mechanisms underlying the response of the brain to stress remain primarily unknown, however. Signal regulatory protein alpha (SIRPalpha) is an Ig-superfamily protein that undergoes tyrosine phosphorylation and binds the protein tyrosine phosphatase Shp2. Here we show that mice expressing a form of SIRPalpha that lacks most of the cytoplasmic region manifest prolonged immobility (depression-like behavior) in the forced swim (FS) test. FS stress induced marked tyrosine phosphorylation of SIRPalpha in the brain of wild-type mice through activation of Src family kinases. The SIRPalpha ligand CD47 was important for such SIRPalpha phosphorylation, and CD47-deficient mice also manifested prolonged immobility in the FS test. Moreover, FS stress-induced tyrosine phosphorylation of both the NR2B subunit of the NMDA subtype of glutamate receptor and the K+-channel subunit Kvbeta2 was regulated by SIRPalpha. Thus, tyrosine phosphorylation of SIRPalpha is important for regulation of depression-like behavior in the response of the brain to stress.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- norepinephrine reuptake inhibitor; assessing antidepressant activity; integrin-associated protein; synaptic plasticity; adhesion molecules; knockout mice; axon guidance; receptor; hippocampus; depression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ohnishi, Hiroshi
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Murata, Takaaki
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Kusakari, Shinya
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Hayashi, Yuriko
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Takao, Keizo
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Maruyama, Toshi
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visa fler...
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Ago, Yukio
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Koda, Ken
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Jin, Feng-Jie
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Okawa, Katsuya
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Oldenborg, Per-A ...
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Okazawa, Hideki
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Murata, Yoji
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Furuya, Nobuhiko
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Matsuda, Toshio
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Miyakawa, Tsuyos ...
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Matozaki, Takash ...
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Umeå universitet