| 1. |
- Charitsis, Vassilis, et al.
(författare)
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'Made to Run' : Biopolitical marketing and the making of the self-quantified runner
- 2019
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Ingår i: Marketing Theory. - : Sage Publications. - 1470-5931 .- 1741-301X. ; 19:3, s. 347-366
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Tidskriftsartikel (refereegranskat)abstract
- While previous critical marketing research on co-creation has focused on how consumers’ cognitive and social abilities are governed, this article focuses on how firms’ marketing strategies attempt to govern every aspect of consumers’ lives. By drawing on a biopolitical framework and a study of Nike+, a marketing system for runners which Nike has developed around its self-tracking devices, three biopolitical marketing dimensions were identified: the gamification of the running experience, the transformation of running into a competitive activity and the conversion of running into a social activity. In identifying these marketing dimensions, the study demonstrates how self-tracking affordances are deployed in the development of a biopolitical marketing environment that tames, captures and appropriates value from different aspects of consumers’ lives, including – and combining – their social behaviours, cognitive capacities and bodily conducts. This article contributes to critical studies of value co-creation by focusing on the tamed self-tracking body as a resource for value creation, but also by demonstrating that consumers engage, through cognitive labour, in the production of the biopolitical environment that leads to their exploitation.
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| 2. |
- Fyrberg, Anna, et al.
(författare)
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NUCLEOSIDE ANALOG ACTIVITY IN MALIGNANT MELANOMA CELL LINES
- 2015
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Ingår i: Nucleosides, Nucleotides & Nucleic Acids. - : Taylor andamp; Francis: STM, Behavioural Science and Public Health Titles. - 1525-7770 .- 1532-2335. ; 34:9, s. 639-649
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Tidskriftsartikel (refereegranskat)abstract
- Mitochondrial deoxyguanosine kinase (dGK), is an enzyme responsible for activation of nucleoside analogs (NAs) to phosphorylated compounds which exert profound cytotoxicity, especially in hematological malignancies. Screening malignant melanoma cell lines against NAs revealed high sensitivity to several of them. This was believed to be due to the high levels of dGK expression in these cells. Downregulation of dGK in the melanoma cell line RaH5 using siRNA did not cause resistance to NAs as expected, but instead cells became more sensitive. This was probably partly due to the increased activity of another mitochondrial enzyme, thymidine kinase 2, seen in transfected cells.
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| 3. |
- Fyrberg Yngfalk, Anna, et al.
(författare)
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Hybridity as Fluid Identity in the Organization of Associations
- 2019. - 1
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Ingår i: Managing Hybrid Organizations. - Cham : Palgrave Macmillan. - 9783319954868 - 9783319954851 ; , s. 109-128
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter addresses the issue of hybridity in non-profit organizations formally run as non-profit associations (NPA) and the case of Swedish FriskisXX1Svettis. It does so by examining and discussing how organizational legitimacy is managed under what is commonly referred to as “marketization”. In contradiction to previous research, we show how the hybrid position of the NPA in the market not only enacts a struggle upon the organization but also leads to a flexibility that is actively utilized in the management of organizational identity and legitimacy. In so doing, the chapter draws attention to two key organizational strategies that help to explain how FriskisXX1Svettis is able to utilize its hybridity in order to maintain legitimacy in the market: adaptation and activation, which creates a fluidness in which the organization is able to maintain and incorporate multiple organizational identities.
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| 4. |
- Fyrberg Yngfalk, Anna
(författare)
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Konsumentbeteende och genus – en forskningsöversikt
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rapporten sammanfatta relevant forskning om konsumentbeteende och genus. Genom att belysa skillnaderna mellan kvinnors och mäns möjligheter att göra medvetna och aktiva beslut i konsumentvardagen är förhoppningen att rapporten kan bidra till ytterligare kunskap och diskussion om hur kvinnor och män ska kunna agera medvetet och aktivt på alla marknader.
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| 5. |
- Fyrberg Yngfalk, Anna, et al.
(författare)
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Ska vi konsumera oss till hälsa?
- 2015
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Ingår i: Organisation & Samhälle. - 2001-9114 .- 2002-0287. ; :2, s. 4-7
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 6. |
- Fyrberg Yngfalk, Anna, 1980-, et al.
(författare)
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Ska vi konsumera oss till hälsa?
- 2015
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Ingår i: Organisation & Samhälle. - Göteborg. - 2001-9114. ; :2, s. 4-7
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
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| 8. |
- Jakobsen, Ingrid, 1984-
(författare)
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Prognostic markers in acute myeloid leukemia : A candidate gene approach
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The standard treatment of acute myeloid leukemia (AML) consists of induction chemotherapy, most commonly daunorubicin together with the nucleoside analogue cytarabine (Ara-C), followed by consolidation chemotherapy and in selected cases allogenic stem cell transplantation (allo-SCT). Despite a high initial response rate, a considerable proportion of all AML cases eventually suffer from relapse and the five-year overall survival rate in patients >60 years is only around 15%. Based on cytogenetic analysis, patients are divided into low risk, intermediate risk, and high-risk groups. While low risk patients have a high chance of reaching and remaining in remission after standard induction therapy, high-risk patients are likely to suffer from relapse and should be scheduled for allo-SCT when first complete remission is reached. The intermediate risk group consists of normal karyotype (NK) patients and those with karyotypes of uncertain clinical relevance, but the outcomes are heterogeneous. In NKAML patients, risk classification has improved with the addition of molecular markers including FLT3 internal tandem duplications (ITD) and mutations of NPM1 and CEBPA. Despite this development, there is a group of patients lacking reliable prognostic markers and in some cases the outcomes predicted do not match the outcomes observed, highlighting the need for additional markers. ABCB1 encodes a transporter protein responsible for the extrusion of cytotoxic compounds, including daunorubicin, over the cell membrane, and is a known resistance mechanism. Ara-C is subject to both activating and inactivating metabolic enzymes including DCK (activating), CDA and cN-II (inactivating). ABCB1, DCK, CDA and cN-II are all polymorphic, and SNPs affecting enzyme function and/or activity have potential as prognostic markers. In addition, recurrent IDH1/2 mutations lead to the expression of an enzyme with neomorphic activity associated with epigenetic alterations and disturbed differentiation. Mutations as well as a SNP in codon 105 of IDH1 have prognostic implications in AML, although the effects of different IDH mutations have been unclear. The aim of this thesis was to investigate SNPs in ABCB1 and genes associated with Ara-C metabolism, mutations in IDH1/2 and the IDH1 SNP, and their associations with treatment response and survival in AML. We show that the 1236C>T and 2677G>T SNPs in ABCB1 influence in vitro sensitivity towards AML drugs, with corresponding effects on NK-AML patient survival. These survival differences were seen mainly in patients lacking FLT3-ITD, further adding to the risk stratification. In contrast, the CDA SNPs 79A>C and -451C>T appear to influence survival mainly in FLT3-ITD positive cases. In conclusion, the above-mentioned SNPs have the potential to add important information to risk classifications especially in NK-AML patients with the ambiguous FLT3-ITD-/NPM1- or FLT3-ITD+/NPM1+ genotypes. In addition, we have shown that IDH2 R140 mutation is associated with impaired survival in AML, and that the IDH1 codon 105 SNP appears to confer a worse outcome in a subset of intermediate risk patients without FLT3-ITD. With the introduction of next generation sequencing into clinical diagnostics, IDH mutations may not only provide prognostic information but also guide the selection of patients for new drugs targeting the variant enzyme. Our results indicate that in addition to leukemia-specific mutations, constitutional SNPs may prove useful for further individualizing care-taking and should be considered when implementing these new techniques.
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| 9. |
- Yngfalk, Carl, 1980-, et al.
(författare)
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Creating the cautious consumer : Marketing managerialism and bio-power in health consumption
- 2015
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Ingår i: Journal of Macromarketing. - : SAGE Publications. - 0276-1467 .- 1552-6534. ; 35:4, s. 435-447
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Tidskriftsartikel (refereegranskat)abstract
- This study examines the power and potential of marketing in the proliferation of health discourses in society. More specifically, drawing on a Foucauldian bio-political framework, it undertakes a discourse analysis of a commercial weight-loss program and the service marketing managerialism it actualizes, focusing on the interactions between service workers and consumers. The study contributes to recent discussions concerning the governmentality of marketing and its effects on consumer well-being by showing how people are invested in identity work in which the body becomes a site of collective control in consumer culture. The study reveals how service marketing is infused with bio-power, which simultaneously spurs people to lose weight and constructs them as cautious consumers that embody increased levels of self-care, control, anxiety and stress. Finally, it is argued that this continuous creation of bodily distress functions as a key mechanism of the contemporary market economy under neoliberal capitalism.
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