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- Bezek, Can Deniz, et al.
(författare)
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Analytical Estimation of Beamforming Speed-of-Sound Using Transmission Geometry
- 2023
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Ingår i: Ultrasonics. - : Elsevier. - 0041-624X .- 1874-9968. ; 134
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Tidskriftsartikel (refereegranskat)abstract
- Most ultrasound imaging techniques necessitate the fundamental step of converting temporal signals received from transducer elements into a spatial echogenecity map. This beamforming (BF) step requires the knowledge of speed-of-sound (SoS) value in the imaged medium. An incorrect assumption of BF SoS leads to aberration artifacts, not only deteriorating the quality and resolution of conventional brightness mode (B-mode) images, hence limiting their clinical usability, but also impairing other ultrasound modalities such as elastography and spatial SoS reconstructions, which rely on faithfully beamformed images as their input. In this work, we propose an analytical method for estimating BF SoS. We show that pixel-wise relative shifts between frames beamformed with an assumed SoS is a function of geometric disparities of the transmission paths and the error in such SoS assumption. Using this relation, we devise an analytical model, the closed form solution of which yields the difference between the assumed and the true SoS in the medium. Based on this, we correct the BF SoS, which can also be applied iteratively. Both in simulations and experiments, lateral B-mode resolution is shown to be improved by ≈ 25% compared to that with an initial SoS assumption error of 3.3% (50 m/s), while localization artifacts from beamforming are also corrected. After 5 iterations, our method achieves BF SoS errors of under 0.6 m/s in simulations. Residual time-delay errors in beamforming 32 numerical phantoms are shown to reduce down to 0.07 µs, with average improvements of up to 21 folds compared to initial inaccurate assumptions. We additionally show the utility of the proposed method in imaging local SoS maps, where using our correction method reduces reconstruction root-mean-square errors substantially, down to their lower-bound with actual BF SoS.
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| 2. |
- Chen, Boqi, et al.
(författare)
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Generative appearance replay for continual unsupervised domain adaptation
- 2023
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Ingår i: Medical Image Analysis. - : Elsevier. - 1361-8415 .- 1361-8423. ; 89, s. 102924-102924
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Tidskriftsartikel (refereegranskat)abstract
- Deep learning models can achieve high accuracy when trained on large amounts of labeled data. However, real-world scenarios often involve several challenges: Training data may become available in installments, may originate from multiple different domains, and may not contain labels for training. Certain settings, for instance medical applications, often involve further restrictions that prohibit retention of previously seen data due to privacy regulations. In this work, to address such challenges, we study unsupervised segmentation in continual learning scenarios that involve domain shift. To that end, we introduce GarDA (Generative Appearance Replay for continual Domain Adaptation), a generative-replay based approach that can adapt a segmentation model sequentially to new domains with unlabeled data. In contrast to single-step unsupervised domain adaptation (UDA), continual adaptation to a sequence of domains enables leveraging and consolidation of information from multiple domains. Unlike previous approaches in incremental UDA, our method does not require access to previously seen data, making it applicable in many practical scenarios. We evaluate GarDA on three datasets with different organs and modalities, where it substantially outperforms existing techniques. Our code is available at: https://github.com/histocartography/generative-appearance-replay.Previous article in issue
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| 3. |
- Pati, Pushpak, et al.
(författare)
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Weakly supervised joint whole-slide segmentation and classification in prostate cancer
- 2023
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Ingår i: Medical Image Analysis. - : Elsevier. - 1361-8415 .- 1361-8423.
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Tidskriftsartikel (refereegranskat)abstract
- The identification and segmentation of histological regions of interest can provide significant support to pathologists in their diagnostic tasks. However, segmentation methods are constrained by the difficulty in obtaining pixel-level annotations, which are tedious and expensive to collect for whole-slide images (WSI). Though several methods have been developed to exploit image-level weak-supervision for WSI classification, the task of segmentation using WSI-level labels has received very little attention. The research in this direction typically require additional supervision beyond image labels, which are difficult to obtain in real-world practice. In this study, we propose WholeSIGHT, a weakly-supervised method that can simultaneously segment and classify WSIs of arbitrary shapes and sizes. Formally, WholeSIGHT first constructs a tissue-graph representation of WSI, where the nodes and edges depict tissue regions and their interactions, respectively. During training, a graph classification head classifies the WSI and produces node-level pseudo-labels via post-hoc feature attribution. These pseudo-labels are then used to train a node classification head for WSI segmentation. During testing, both heads simultaneously render segmentation and class prediction for an input WSI. We evaluate the performance of WholeSIGHT on three public prostate cancer WSI datasets. Our method achieves state-of-the-art weakly-supervised segmentation performance on all datasets while resulting in better or comparable classification with respect to state-of-the-art weakly-supervised WSI classification methods. Additionally, we assess the generalization capability of our method in terms of segmentation and classification performance, uncertainty estimation, and model calibration. Our code is available at: https://github.com/histocartography/wholesight.
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