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- Terenin, V. I., et al.
(författare)
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1-(Trifluoromethyl)-3,4-dihydropyrrolo-[1,2-a] pyrazines: synthesis and reactions with O- and N-nucleophiles
- 2011
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Ingår i: Chemistry of Heterocyclic Compounds. - : Springer Science and Business Media LLC. - 0009-3122 .- 1573-8353. ; 46:10, s. 1271-1278
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Tidskriftsartikel (refereegranskat)abstract
- The method of synthesis has been developed and reactions of 1-(trifluoromethyl)-3,4-dihydro-pyrrolo[1,2-a]pyrazines with O- and N-nucleophiles have been studied. It was found that reactions of nucleophiles with 1-(trifluoro-methyl)pyrrolo[1,2-a]pyrazines transforms the trifluoromethyl group to amide and amidine groups together with aromatization of the pyrrolo[1,2-a]pyrazine system as a result of the formal elimination of a molecule of hydrogen fluoride.
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