| 1. |
- Gallagher, Michael D., et al.
(författare)
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TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions
- 2014
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 127:3, s. 407-418
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Tidskriftsartikel (refereegranskat)abstract
- Hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (C9orf72) have recently been linked to frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis, and may be the most common genetic cause of both neurodegenerative diseases. Genetic variants at TMEM106B influence risk for the most common neuropathological subtype of FTLD, characterized by inclusions of TAR DNA-binding protein of 43 kDa (FTLD-TDP). Previous reports have shown that TMEM106B is a genetic modifier of FTLD-TDP caused by progranulin (GRN) mutations, with the major (risk) allele of rs1990622 associating with earlier age at onset of disease. Here, we report that rs1990622 genotype affects age at death in a single-site discovery cohort of FTLD patients with C9orf72 expansions (n = 14), with the major allele correlated with later age at death (p = 0.024). We replicate this modifier effect in a 30-site international neuropathological cohort of FTLD-TDP patients with C9orf72 expansions (n = 75), again finding that the major allele associates with later age at death (p = 0.016), as well as later age at onset (p = 0.019). In contrast, TMEM106B genotype does not affect age at onset or death in 241 FTLD-TDP cases negative for GRN mutations or C9orf72 expansions. Thus, TMEM106B is a genetic modifier of FTLD with C9orf72 expansions. Intriguingly, the genotype that confers increased risk for developing FTLD-TDP (major, or T, allele of rs1990622) is associated with later age at onset and death in C9orf72 expansion carriers, providing an example of sign epistasis in human neurodegenerative disease.
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| 2. |
- Aalto, Susanne, 1964, et al.
(författare)
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Winds of change - a molecular outflow in NGC 1377? The anatomy of an extreme FIR-excess galaxy
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 546, s. Article Number: A68-
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Tidskriftsartikel (refereegranskat)abstract
- Aims. Our goal was to investigate the molecular gas distribution and kinematics in the extreme far-infrared (FIR) excess galaxy NGC 1377 and to address the nature and evolutionary status of the buried source. Methods. We used high-(0.'' 65 x 0.'' 52, (65 x 52 pc)) and low-(4.'' 88 x 2.'' 93) resolution SubMillimeter Array (SMA) observations to image the (CO)-C-12 and (CO)-C-13 2-1 line emission. Results. We find bright, complex (CO)-C-12 2-1 line emission in the inner 400 pc of NGC 1377. The (CO)-C-12 2-1 line has wings that are tracing a kinematical component that appears to be perpendicular to the component traced by the line core. Together with an intriguing X-shape of the integrated intensity and dispersion maps, this suggests that the molecular emission of NGC 1377 consists of a disk-outflow system. Lower limits to the molecular mass and outflow rate are M-out(H-2) > 1 x 10(7) M-circle dot and (M) over dot > 8 M-circle dot yr(-1). The age of the proposed outflow is estimated to be 1.4 Myr, the extent to be 200 pc and the outflow speed to be V-out = 140 km s(-1). The total molecular mass in the SMA map is estimated to M-tot(H-2) = 1.5 x 10(8) M-circle dot (on a scale of 400 pc) while in the inner r = 29 pc the molecular mass is M-core(H-2) = 1.7 x 10(7) M-circle dot with a corresponding H-2 column density of N(H-2) = 3.4 x 10(23) cm(-2) and an average (CO)-C-12 2-1 brightness temperature of 19 K. (CO)-C-13 2-1 emission is found at a factor 10 fainter than (CO)-C-12 in the low-resolution map while (CO)-O-18 2-1 remains undetected. We find weak 1 mm continuum emission of 2.4 mJy with spatial extent less than 400 pc. Conclusions. Observing the molecular properties of the FIR-excess galaxy NGC 1377 allows us to probe the early stages of nuclear activity and the onset of feedback in active galaxies. The age of the outflow supports the notion that the current nuclear activity is young - a few Myr. The outflow may be powered by radiation pressure from a compact, dust enshrouded nucleus, but other driving mechanisms are possible. The buried source may be an active galactic nucleus (AGN) or an extremely young (1 Myr) compact star-burst. Limitations on size and mass lead us to favor the AGN scenario, but additional studies are required to settle this question. In either case, the wind with its implied mass outflow rate will quench the nuclear power source within the very short time of 5-25 Myr. It is possible, however, that the gas is unable to escape the galaxy and may eventually fall back onto NGC 1377 again.
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| 3. |
- Elmegreen, Debra Meloy, et al.
(författare)
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HIERARCHICAL STAR FORMATION IN NEARBY LEGUS GALAXIES
- 2014
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Ingår i: Astrophysical Journal Letters. - 2041-8205. ; 787:1, s. L15-
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Tidskriftsartikel (refereegranskat)abstract
- Hierarchical structure in ultraviolet images of 12 late-type LEGUS galaxies is studied by determining the numbers and fluxes of nested regions as a function of size from similar to 1 to similar to 200 pc, and the number as a function of flux. Two starburst dwarfs, NGC 1705 and NGC 5253, have steeper number-size and flux-size distributions than the others, indicating high fractions of the projected areas filled with star formation. Nine subregions in seven galaxies have similarly steep number-size slopes, even when the whole galaxies have shallower slopes. The results suggest that hierarchically structured star-forming regions several hundred parsecs or larger represent common unit structures. Small galaxies dominated by only a few of these units tend to be starbursts. The self-similarity of young stellar structures down to parsec scales suggests that star clusters form in the densest parts of a turbulent medium that also forms loose stellar groupings on larger scales. The presence of super star clusters in two of our starburst dwarfs would follow from the observed structure if cloud and stellar subregions more readily coalesce when self-gravity in the unit cell contributes more to the total gravitational potential.
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| 4. |
- Konig, Sabine, et al.
(författare)
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Molecular tendrils feeding star formation in the Eye of the Medusa -- The Medusa merger in high resolution 12CO 2–1 maps
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 569, s. Art. no. A6-
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Tidskriftsartikel (refereegranskat)abstract
- Studying molecular gas properties in merging galaxies gives us important clues to the onset and evolution of interaction-triggered starbursts. NGC 4194 (the Medusa merger) is particularly interesting to study, since its FIR-to-CO luminosity ratio rivals that of ultraluminous galaxies (ULIRGs), despite its lower luminosity compared to ULIRGs, which indicates a high star formation efficiency (SFE) that is relative to even most spirals and ULIRGs. We study the molecular medium at an angular resolution of 0.65′′ × 0.52′′ (~120 × 98 pc) through our observations of 12CO 2−1 emission using the Submillimeter Array (SMA). We compare our 12CO 2−1 maps with the optical Hubble Space Telescope and high angular resolution radio continuum images to study the relationship between molecular gas and the other components of the starburst region. The molecular gas is tracing the complicated dust lane structure of NGC 4194 with the brightest emission being located in an off-nuclear ring-like structure with ~320 pc radius, the Eye of the Medusa. The bulk CO emission of the ring is found south of the kinematical center of NGC 4194. The northern tip of the ring is associated with the galaxy nucleus, where the radio continuum has its peak. Large velocity widths associated with the radio nucleus support the notion of NGC 4194 hosting an active galactic nucleus. A prominent, secondary emission maximum in the radio continuum is located inside the molecular ring. This suggests that the morphology of the ring is partially influenced by massive supernova explosions. From the combined evidence, we propose that the Eye of the Medusa contains a shell of swept up material where we identify a number of giant molecular associations. We propose that the Eye may be the site of an efficient starburst of 5−7 M⊙ yr-1, but it would still constitute only a fraction of the 30−50 M⊙ yr-1 star formation rate of the Medusa. Furthermore, we find that ~50% of the molecular mass of NGC 4194 is found in extended filamentary-like structures tracing the minor and major axis dust lanes. We suggest that molecular gas is transported along these lanes, providing the central starburst region with fuel. Interestingly, a comparison with locations of super star clusters (SSCs) reveal that the molecular gas and the SSCs are not co-spatial.
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| 5. |
- Konig, Sabine, et al.
(författare)
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The NGC 1614 interacting galaxy Molecular gas feeding a "ring of fire"
- 2013
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 553
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Tidskriftsartikel (refereegranskat)abstract
- Minor mergers frequently occur between giant and gas-rich low-mass galaxies and can provide significant amounts of interstellar matter to refuel star formation and power active galactic nuclei (AGN) in the giant systems. Major starbursts and/or AGN result when fresh gas is transported and compressed in the central regions of the giant galaxy. This is the situation in the starburst minor merger NGC 1614, whose molecular medium we explore at half-arcsecond angular resolution through our observations of (CO)-C-12(2-1) emission using the Submillimeter Array (SMA). We compare our (CO)-C-12(2-1) maps with optical and Pa alpha, Hubble Space Telescope and high angular resolution radio continuum images to study the relationships between dense molecular gas and the NGC 1614 starburst region. The most intense (CO)-C-12 emission occurs in a partial ring with similar to 230 pc radius around the center of NGC 1614, with an extension to the northwest into the dust lane that contains diffuse molecular gas. We resolve ten giant molecular associations (GMAs) in the ring, which has an integrated molecular mass of similar to 8 x 10(8) M-circle dot. Our interferometric observations filter out a large part of the (CO)-C-12(1-0) emission mapped at shorter spacings, indicating that most of the molecular gas is diffuse and that GMAs only exist near and within the circumnuclear ring. The molecular ring is uneven with most of the mass on the western side, which also contains GMAs extending into a pronounced tidal dust lane. The spatial and kinematic patterns in our data suggest that the northwest extension of the ring is a cosmic umbilical cord that is feeding molecular gas associated with the dust lane and tidal debris into the nuclear ring, which contains the bulk of the starburst activity. The astrophysical process for producing a ring structure for the final resting place of accreted gas in NGC 1614 is not fully understood, but the presence of numerous GMAs suggests an orbit-crowding or resonance phenomenon. There is some evidence that star formation is progressing radially outward within the ring, indicating that a self-triggering mechanism may also affect star formation processes. The net result of this merger therefore very likely increases the central concentration of stellar mass in the NGC 1614 remnant giant system.
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