Sökning: WFRF:(Gamble Greg D.)
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Circulating levels ...
Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure
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- Vergaro, Giuseppe (författare)
- Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.
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- Gentile, Francesco (författare)
- Pisa Univ Hosp, Cardiol Div, Pisa, Italy.
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- Aimo, Alberto (författare)
- Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.
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visa fler...
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- Januzzi, James L. (författare)
- Massachusetts Gen Hosp, Boston, MA 02114 USA.;Baim Inst Clin Res, Boston, MA USA.
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- Richards, A. Mark (författare)
- Univ Otago, Dept Med, Dunedin, New Zealand.;Natl Univ Singapore, Natl Univ Heart Ctr, Singapore, Singapore.
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- Lam, Carolyn S. P. (författare)
- Natl Heart Ctr Singapore, Singapore, Singapore.;Duke Natl Univ Singapore, Singapore, Singapore.
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- Boer, Rudolf A. (författare)
- Univ Med Ctr Groningen, Groningen, Netherlands.
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- Meems, Laura M. G. (författare)
- Univ Med Ctr Groningen, Groningen, Netherlands.
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- Latini, Roberto (författare)
- Ist Ric Farmacol Mario Negri IRCCS, Milan, Italy.
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- Staszewsky, Lidia (författare)
- Ist Ric Farmacol Mario Negri IRCCS, Milan, Italy.
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- Anand, Inder S. (författare)
- Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA.;VA Med Ctr, Minneapolis, MN USA.
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- Cohn, Jay N. (författare)
- Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA.
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- Ueland, Thor (författare)
- Oslo Univ Hosp, Oslo, Norway.;Oslo Univ Hosp, Rikshosp, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.;Univ Tromso, KG Jebsen Thrombosis Res & Expertise Ctr, Tromso, Norway.
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- Gullestad, Lars (författare)
- Univ Oslo, KG Jebsen Ctr Cardiac Res, Oslo, Norway.;Oslo Univ Hosp, Ctr Heart Failure Res, Oslo, Norway.
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- Aukrust, Pal (författare)
- Oslo Univ Hosp, Rikshosp, Oslo, Norway.
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- Rocca, Hans-Peter Brunner-La (författare)
- Maastricht Univ, Med Ctr, Maastricht, Netherlands.
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- Bayes-Genis, Antoni (författare)
- Hosp Univ Germans Trias I Pujol, Badalona, Barcelona, Spain.;Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain.
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- Lupon, Josep (författare)
- Hosp Univ Germans Trias I Pujol, Badalona, Barcelona, Spain.;Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain.
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- Yoshihisa, Akiomi (författare)
- Fukushima Med Univ, Dept Internal Med 1, Fukushima, Japan.
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- Takeishi, Yasuchika (författare)
- Fukushima Med Univ, Dept Internal Med 1, Fukushima, Japan.
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- Egstrup, Michael (författare)
- Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark.
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- Gustafsson, Ida (författare)
- Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark.
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- Gaggin, Hanna K. (författare)
- Massachusetts Gen Hosp, Heart Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Eggers, Kai M., 1962- (författare)
- Uppsala universitet,Kardiologi
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- Huber, Kurt (författare)
- Wilhelminenspital Stadt Wien, Vienna, Austria.;Sigmund Freud Univ, Med Sch, Vienna, Austria.
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- Gamble, Greg D. (författare)
- Univ Auckland, Fac Med & Hlth Sci, Auckland, New Zealand.
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- Ling, Lieng H. (författare)
- Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore.;Natl Univ Singapore, Singapore, Singapore.
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- Leong, Kui Toh Gerard (författare)
- Changi Gen Hosp, Singapore, Singapore.
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- Yeo, Poh Shuah Daniel (författare)
- Tan Tock Seng Hosp, Singapore, Singapore.
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- Ong, Hean Yee (författare)
- Khoo Teck Puat Hosp, Singapore, Singapore.
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- Jaufeerally, Fazlur (författare)
- Singapore Gen Hosp, Singapore, Singapore.
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- Ng, Tze P. (författare)
- Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore.;Natl Univ Singapore, Singapore, Singapore.
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- Troughton, Richard (författare)
- Univ Otago, Dept Med, Dunedin, New Zealand.;Natl Univ Singapore, Natl Univ Heart Ctr, Singapore, Singapore.
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- Doughty, Robert N. (författare)
- Univ Auckland, Fac Med & Hlth Sci, Auckland, New Zealand.
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- Devlin, Gerry (författare)
- Gisborne Hosp, Gisborne, New Zealand.
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- Lund, Mayanna (författare)
- Middlemore Hosp, Auckland, New Zealand.
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- Giannoni, Alberto (författare)
- Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.
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- Passino, Claudio (författare)
- Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.
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- Emdin, Michele (författare)
- Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.
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Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy. Pisa Univ Hosp, Cardiol Div, Pisa, Italy. (creator_code:org_t)
- 2022-05-05
- 2022
- Engelska.
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Ingår i: ESC Heart Failure. - : John Wiley & Sons. - 2055-5822. ; 9:4, s. 2084-2095
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims To define plasma concentrations, determinants, and optimal prognostic cut-offs of soluble suppression of tumorigenesis-2 (sST2), high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in women and men with chronic heart failure (HF). Methods and results Individual data of patients from the Biomarkers In Heart Failure Outpatient Study (BIOS) Consortium with sST2, hs-cTnT, and NT-proBNP measured were analysed. The primary endpoint was a composite of 1 year cardiovascular death and HF hospitalization. The secondary endpoints were 5 year cardiovascular and all-cause death. The cohort included 4540 patients (age 67 +/- 12 years, left ventricular ejection fraction 33 +/- 13%, 1111 women, 25%). Women showed lower sST2 (24 vs. 27 ng/mL, P < 0.001) and hs-cTnT level (15 vs. 20 ng/L, P < 0.001), and similar concentrations of NT-proBNP (1540 vs. 1505 ng/L, P = 0.408). Although the three biomarkers were confirmed as independent predictors of outcome in both sexes, the optimal prognostic cut-off was lower in women for sST2 (28 vs. 31 ng/mL) and hs-cTnT (22 vs. 25 ng/L), while NT-proBNP cut-off was higher in women (2339 ng/L vs. 2145 ng/L). The use of sex-specific cut-offs improved risk prediction compared with the use of previously standardized prognostic cut-offs and allowed to reclassify the risk of many patients, to a greater extent in women than men, and for hs-cTnT than sST2 or NT-proBNP. Specifically, up to 18% men and up to 57% women were reclassified, by using the sex-specific cut-off of hs-cTnT for the endpoint of 5 year cardiovascular death. Conclusions In patients with chronic HF, concentrations of sST2 and hs-cTnT, but not of NT-proBNP, are lower in women. Lower sST2 and hs-cTnT and higher NT-proBNP cut-offs for risk stratification could be used in women.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Chronic heart failure
- Sex
- Women
- Prognosis
- sST2
- High-sensitivity troponin T
- NT-proBNP
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Vergaro, Giusepp ...
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Gentile, Frances ...
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Aimo, Alberto
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Januzzi, James L ...
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Richards, A. Mar ...
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Lam, Carolyn S. ...
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visa fler...
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Boer, Rudolf A.
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Meems, Laura M. ...
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Latini, Roberto
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Staszewsky, Lidi ...
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Anand, Inder S.
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Cohn, Jay N.
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Ueland, Thor
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Gullestad, Lars
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Aukrust, Pal
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Rocca, Hans-Pete ...
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Bayes-Genis, Ant ...
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Lupon, Josep
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Yoshihisa, Akiom ...
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Takeishi, Yasuch ...
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Egstrup, Michael
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Gustafsson, Ida
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Gaggin, Hanna K.
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Eggers, Kai M., ...
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Huber, Kurt
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Gamble, Greg D.
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Ling, Lieng H.
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Leong, Kui Toh G ...
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Yeo, Poh Shuah D ...
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Ong, Hean Yee
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Jaufeerally, Faz ...
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Ng, Tze P.
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Troughton, Richa ...
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Doughty, Robert ...
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Devlin, Gerry
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Lund, Mayanna
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Giannoni, Albert ...
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Passino, Claudio
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Emdin, Michele
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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ESC Heart Failur ...
- Av lärosätet
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Uppsala universitet