| 1. |
- Gao, Tao, et al.
(författare)
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Pdx1 Maintains beta Cell Identity and Function by Repressing an alpha Cell Program
- 2014
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Ingår i: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 19:2, s. 259-271
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Tidskriftsartikel (refereegranskat)abstract
- Pdx1 is a homeobox-containing transcription factor that plays a key role in pancreatic development and adult beta cell function. In this study, we traced the fate of adult beta cells after Pdx1 deletion. As expected, beta-cell-specific removal of Pdx1 resulted in severe hyperglycemia within days. Surprisingly, a large fraction of Pdx1-deleted cells rapidly acquired ultrastructural and physiological features of a cells, indicating that a robust cellular reprogramming had occurred. Reprogrammed cells exhibited a global transcriptional shift that included derepression of the alpha cell transcription factor MafB, resulting in a transcriptional profile that closely resembled that of alpha cells. These findings indicate that Pdx1 acts as a master regulator of beta cell fate by simultaneously activating genes essential for beta cell identity and repressing those associated with alpha cell identity. We discuss the significance of these findings in the context of the emerging notion that loss of beta cell identity contributes to the pathogenesis of type 2 diabetes.
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| 2. |
- Huang, Xin, 1982-, et al.
(författare)
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Sensor Aided Authentication
- 2010
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Ingår i: Communications in Computer and Information Science Volume 76 CCIS, 2010. - Berlin, Heidelberg : Springer. - 3642133649 - 9783642133640 ; , s. 265-277
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Konferensbidrag (refereegranskat)abstract
- The sharing of sensor data globally becomes possible by the development of wireless sensor network, cloud computing, and other related technologies. These new trends can also benefit information security. In this paper, the sensor data is involved in the authentication procedure which is one main component of security systems. Sensor aided password is proposed. In addition, the architecture for sensor aided authentication corresponding to the simple authentication scenario is also designed. Sensor data aided password generation and utilization bring convenience to users without weakening the password strength.
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