| 1. |
- Tran, K. B., et al.
(författare)
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The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet. - 0140-6736. ; 400:10352, s. 563-591
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Tidskriftsartikel (refereegranskat)abstract
- Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 2. |
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| 3. |
- Sheena, B. S., et al.
(författare)
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Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet Gastroenterology & Hepatology. - : Elsevier BV. - 2468-1253. ; 7:9, s. 796-829
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Tidskriftsartikel (refereegranskat)abstract
- Background Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-ofsample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4 center dot 1% (95% uncertainty interval [UI] 3 center dot 7 to 4 center dot 5), corresponding to 316 million (284 to 351) infected people. There was a 31 center dot 3% (29 center dot 0 to 33 center dot 9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76 center dot 8% (76 center dot 2 to 77 center dot 5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 000 global deaths (487 000 to 630 000) in 2019. The number of HBV-related deaths increased between 1990 and 2019 (by 5 center dot 9% [-5 center dot 6 to 19 center dot 2]) and between 2015 and 2019 (by 2 center dot 9% [-5 center dot 9 to 11 center dot 3]). By contrast, all-age and age-standardised death rates due to HBV-related diseases decreased during these periods. We compared estimates for 2019 in 194 WHO locations to WHO-GHSS 2020 targets, and found that four countries achieved a 10% reduction in deaths, 15 countries achieved a 30% reduction in new cases, and 147 countries achieved a 1% prevalence in children younger than 5 years. As of 2019, 68 of 194 countries had already achieved the 2030 target proposed in WHO Interim Guidance of an all-age HBV-related death rate of four per 100 000. Interpretation The prevalence of chronic HBV infection declined over time, particularly in children younger than 5 years, since the introduction of hepatitis B vaccination. HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and cohort effects. By 2019, many countries had met the interim seroprevalence target for children younger than 5 years, but few countries had met the WHO-GHSS interim targets for deaths and new cases. Progress according to all indicators must be accelerated to meet 2030 targets, and there are marked disparities in burden and progress across the world. HBV interventions, such as vaccination, testing, and treatment, must be strategically supported and scaled up to achieve elimination.
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| 4. |
- Sbarra, AN, et al.
(författare)
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Mapping routine measles vaccination in low- and middle-income countries
- 2021
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 589:7842, s. 415-
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Tidskriftsartikel (refereegranskat)abstract
- The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children.
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| 5. |
- Afshari, Davood, et al.
(författare)
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Optimization in the Resistant Spot-Welding Process of AZ61 Magnesium Alloy
- 2022
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Ingår i: Strojniski vestnik. - : Faculty of Mechanical Engineering. - 0039-2480. ; 68:7-8, s. 485-492
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, an integrated artificial neural network (ANN) and multi-objective genetic algorithm (GA) are developed to optimize the resistance spot welding (RSW) of AZ61 magnesium alloy. Since the stability and strength of a welded joint are strongly dependent on the size of the nugget and the residual stresses created during the welding process, the main purpose of the optimization is to achieve the maximum size of the nugget and minimum tensile residual stress in the weld zone. It is identified that the electrical current, welding time, and electrode force are the main welding parameters affecting the weld quality. The experiments are carried out based on the full factorial design of experiments (DOE). In order to measure the residual stresses, an X-ray diffraction technique is used. Moreover, two separate ANNs are developed to predict the nugget size and the maximum tensile residual stress based on the welding parameters. The ANN is integrated with a multi-objective GA to find the optimum welding parameters. The findings show that the integrated optimization method presented in this study is effective and feasible for optimizing the RSW joints and process.
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| 6. |
- Bahrami, Saeed, et al.
(författare)
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Identifying a simplified model for heavy duty gas turbine
- 2014
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Ingår i: Journal of Mechanical Science and Technology. - : Springer Science and Business Media LLC. - 1738-494X .- 1976-3824. ; 28:6, s. 2399-2408
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Tidskriftsartikel (refereegranskat)abstract
- A dynamic model was developed for long-term simulation of a heavy duty gas turbine. The model includes the essential control algorithm of the gas turbine as well as the most common outputs and other important intermediate variables. Control algorithm details, such as wind up protection and load limiter algorithm which have large effect on gas turbine transient behavior, are included. The model parameters are identified by applying genetic algorithm and least squares algorithm on regular operational data from a real plant to better match the model response to the real plant. The simulation results have been validated with real plant data and shown to have valid accuracy for many engineering applications.
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| 7. |
- Bahrami, Saeed, et al.
(författare)
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Improving the Transient Performance of the Gas Turbine by Steam Injection during Frequency Dips
- 2013
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Ingår i: Energies. - : MDPI AG. - 1996-1073. ; 6:10, s. 5283-5296
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Tidskriftsartikel (refereegranskat)abstract
- Single-shaft gas turbines are sensitive to frequency changes which might affect the grid stability during large frequency drops. This paper presents a new control system that uses steam injection as an auxiliary input to improve the transient performance of the gas turbine during frequency drops. Steam injection is beneficial because it reduces the peak temperature in the combustion chamber and augments the output power by increasing the mass flow through the turbine. The use of this auxiliary input is based on the event-based control approach. It means that during the frequency drop, the controller exploits the steam injection to help the main control loop recover the frequency and when the frequency reaches its predefined value, the system will return to its normal operation. The performance of the proposed control algorithm is investigated under different scenarios and the results show that the application of steam injection improves the performance of the regular control algorithm significantly, especially near full load condition.
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| 8. |
- Bahrami, Saeed, et al.
(författare)
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Performance Comparison between Steam Injected Gas Turbine and Combined Cycle during Frequency Drops
- 2015
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Ingår i: Energies. - : MDPI AG. - 1996-1073. ; 8:8, s. 7582-7592
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Tidskriftsartikel (refereegranskat)abstract
- Single-shaft gas turbine and its cycles are sensitive to frequency drops and, therefore, sudden change loads or large frequency dips might affect their stability. This phenomenon is related to the reduction of the air mass flow passing through the machine during the frequency dips, which might lead to an interaction between governor and temperature control loop. In this paper, the performance of the combined cycle and steam-injected gas turbine are studied during frequency dips and transient maneuvers. For this purpose, two similar units are developed based on these cycles and their performances are studied in different scenarios. The simulation results show that the steam injected gas turbine has a better performance during frequency drops and it can handle relatively larger change loads.
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| 9. |
- Danandeh Mehr, Ali, et al.
(författare)
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VMD-GP : A New Evolutionary Explicit Model for Meteorological Drought Prediction at Ungauged Catchments
- 2023
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Ingår i: Water (Switzerland). - 2073-4441. ; 15:15
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Tidskriftsartikel (refereegranskat)abstract
- Meteorological drought is a common hydrological hazard that affects human life. It is one of the significant factors leading to water and food scarcity. Early detection of drought events is necessary for sustainable agricultural and water resources management. For the catchments with scarce meteorological observatory stations, the lack of observed data is the main leading cause of unfeasible sustainable watershed management plans. However, various earth science and environmental databases are available that can be used for hydrological studies, even at a catchment scale. In this study, the Global Drought Monitoring (GDM) data repository that provides real-time monthly Standardized Precipitation and Evapotranspiration Index (SPEI) across the globe was used to develop a new explicit evolutionary model for SPEI prediction at ungauged catchments. The proposed model, called VMD-GP, uses an inverse distance weighting technique to transfer the GDM data to the desired area. Then, the variational mode decomposition (VMD), in conjunction with state-of-the-art genetic programming, is implemented to map the intrinsic mode functions of the GMD series to the subsequent SPEI values in the study area. The suggested model was applied for the month-ahead prediction of the SPEI series at Erbil, Iraq. The results showed a significant improvement in the prediction accuracy over the classic GP and gene expression programming models developed as the benchmarks.
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| 10. |
- Esmaeeli, Ali, 1996, et al.
(författare)
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A Comprehensive Review on Pulp and Paper Industries Wastewater Treatment Advances
- 2023
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Ingår i: Industrial & Engineering Chemistry Research. - 1520-5045 .- 0888-5885. ; 62:21, s. 8119-8145
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Forskningsöversikt (refereegranskat)abstract
- The pulp and paper industry generates vast amounts of wastewater, and its character heavily depends on various factors (raw material, the undertaken process, the final product, etc.). The wastewater from this sector, which originates from several sources in each mill and are mostly combined, is polluting and hazardous. This paper presents a state-of-the-art review of the physical, chemical, biological, and advanced hybrid treatment techniques, concerning their effectiveness in removing specific pollutants, namely, chemical oxygen demand, lignin, color, and adsorbable organo-halogens. Throughout the manuscript, at the end of each section, a conclusive comparison has been presented and the proper method is introduced. Furthermore, numeric data regarding the effectiveness of each technique toward each pollutant are gathered from the literature and are available in the Supporting Information of the paper. Biological treatment processes using anaerobic-aerobic treatment mostly cure organic biodegradable contaminants (75-90% COD removal). Moreover, biological treatment using a consortium of microorganisms can potentially increase color removal efficiency (from 65 to 97%). Hybrid treatment is also among the candidates for color removal. To treat complex matters (lignin and AOX), physical and chemical treatments have shown promising performance, but they are generally expensive and impractical to treat huge amounts of wastewater. For the treatment of high molecular weight contaminants (lignin) advanced oxidation processes (AOPs), including ozonation and Fenton-based treatment, have shown great performance (90-99%); however, they are limited due to their maintenance and operation costs. To overcome these challenges, source separation of the wastewater streams in the pulp and paper industry is recommended. AOPs or membrane technologies or hybrid processes are suggested for the bleaching effluent (80% AOX removal), which is relatively low in amount, and a combination of conventional treatment processes would be preferred to treat wastewater streams that are more biodegradable. The biological performance can also be enhanced using granular activated carbon on the sequence. Finally, for treating black liquor, adsorption processes have proven to be the prime candidate.
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