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- Banfi, C, et al.
(författare)
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Prenylcysteine oxidase 1, an emerging player in atherosclerosis
- 2021
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 1109-
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Tidskriftsartikel (refereegranskat)abstract
- The research into the pathophysiology of atherosclerosis has considerably increased our understanding of the disease complexity, but still many questions remain unanswered, both mechanistically and pharmacologically. Here, we provided evidence that the pro-oxidant enzyme Prenylcysteine Oxidase 1 (PCYOX1), in the human atherosclerotic lesions, is both synthesized locally and transported within the subintimal space by proatherogenic lipoproteins accumulating in the arterial wall during atherogenesis. Further, Pcyox1 deficiency in Apoe-/- mice retards atheroprogression, is associated with decreased features of lesion vulnerability and lower levels of lipid peroxidation, reduces plasma lipid levels and inflammation. PCYOX1 silencing in vitro affects the cellular proteome by influencing multiple functions related to inflammation, oxidative stress, and platelet adhesion. Collectively, these findings identify the pro-oxidant enzyme PCYOX1 as an emerging player in atherogenesis and, therefore, understanding the biology and mechanisms of all functions of this unique enzyme is likely to provide additional therapeutic opportunities in addressing atherosclerosis.
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- Ghilardi, A., et al.
(författare)
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Brayton pumped thermal energy storage : Optimal dispatchment in multi-energy districts
- 2024
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Ingår i: Energy Conversion and Management. - : Elsevier. - 0196-8904 .- 1879-2227. ; 314
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Tidskriftsartikel (refereegranskat)abstract
- Energy storage systems play a crucial role in supporting the integration of renewable energy sources. In this framework, Brayton Pumped Thermal Energy Storage is an emerging technology thanks to many positive features, including geographical and raw materials independence, long lifetime, and peculiar sector-coupling capabilities. By storing electric energy as thermal exergy, this technology offers the flexibility to discharge energy directly for heating or cooling applications or convert it back into electricity as needed by the grid. This dual functionality fits well with the multi-energy intrinsic nature of urban districts in which electrical and thermal energy carriers are involved. This paper aims then to evaluate the potential economic benefit due to the usage of a Brayton based Pumped Thermal Energy Storage as multi-energy device instead of a solely electric-to-electric. An urban district with thermal and electric requirements is used as a case study to investigate the techno-economic performance of the mentioned storage capacity when coupled to photo-voltaic plants to simulate deep-decarbonization scenarios. The system day-ahead optimization, performed through a Mixed Integer Linear Programming approach, aims to minimize the operational cost computed over a 24-h horizon. The results highlight that operational yearly cost savings are 5–10 % when using the multi-energy storage functionalities compared to the standard electric-to-electric operation. Despite the cost reduction, allowing only direct heating causes unavoidable thermal curtailment losses in the 6–10 % range. However, these losses can be reduced to 3 % by introducing the additional direct cooling functionality, bringing the best performances from the economic and thermodynamic standpoints.
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- Walsh, Kevin, et al.
(författare)
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Holocene demographic fluctuations, climate and erosion in the Mediterranean : A meta data-analysis
- 2019
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Ingår i: The Holocene. - : SAGE Publications. - 0959-6836 .- 1477-0911. ; 29:5, s. 864-885
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Tidskriftsartikel (refereegranskat)abstract
- As part of the Changing the Face of the Mediterranean Project, we consider how human pressure and concomitant erosion has affected a range of Mediterranean landscapes between the Neolithic and, in some cases, the post-medieval period. Part of this assessment comprises an investigation of relationships among palaeodemographic data, evidence for vegetation change and some consideration of rapid climate change events. The erosion data include recent or hitherto unpublished work from the authors. Where possible, we consider summed probabilities of 14C dates as well as the first published synthesis of all known optically stimulated luminescence dated sequences. The results suggest that while there were some periods when erosion took place contemporaneously across a number of regions, possibly induced by climate changes, more often than not, we see a complex and heterogeneous interplay of demographic and environmental changes that result in a mixed pattern of erosional activity across the Mediterranean.
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