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Pro-inflammatory bi...
Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus : a proof-of-concept study.
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- Salvi, Giovanni E (författare)
- University of Bern, Bern, Switzerland
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- Franco, Lea M (författare)
- University of Michigan, Ann Arbor, MI, USA
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- Braun, Thomas M (författare)
- University of Michigan, Ann Arbor, MI, USA
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visa fler...
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- Lee, Angie (författare)
- University of Michigan, Ann Arbor, MI, USA
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- Persson, G. Rutger (författare)
- University of Bern, Bern, Switzerland
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- Lang, Niklaus P (författare)
- University of Bern, Bern, Switzerland & University of Hong Kong
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- Giannobile, William V (författare)
- University of Michigan, Ann Arbor, MI, USA
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visa färre...
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(creator_code:org_t)
- 2010
- 2010
- Engelska.
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Ingår i: Journal of Clinical Periodontology. - 0303-6979 .- 1600-051X. ; 37:1, s. 9-16
- Relaterad länk:
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https://doi.org/10.1...
Abstract
Ämnesord
Stäng
- AIM: To compare gingival crevicular fluid (GCF) biomarker levels and microbial distribution in plaque biofilm (SP) samples for subjects with type 1 diabetes (T1DM) versus healthy subjects without diabetes during experimental gingivitis (EG).MATERIALS AND METHODS: A total of nine T1DM patients and nine healthy controls of age and gender similar to the T1DM patients were monitored for 35 days during EG. Hygiene practices were stopped for 3 weeks, and GCF, SP, plaque index (PI) and gingival index were determined. IL-1beta, IL-8, MMP-8 and MMP-9 were quantified by enzyme-linked immunosorbent assay, and SP samples were assessed by DNA-DNA hybridization for a panel of 40 subgingival microbial species.RESULTS: IL-1beta levels in T1DM patients were elevated compared with healthy individuals, and showed differences between groups at 7-21 days while healthy patients showed IL-1beta increases from baseline to 14-21 days (p<0.05). Differences were observed in MMP-9 levels between patients with and without T1DM at 7-14 days (p<0.05). Orange complex species and PI measurements displayed a superior correlation with biomarker levels when compared with other complexes or clinical measurements during EG.CONCLUSIONS: The mean GCF biomarker levels for IL-1beta and MMP-8 were most significantly elevated in T1DM subjects compared with healthy individuals during EG, not resulting from differences in the mean PI or microbial composition.
Ämnesord
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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