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- Stroth, U., et al.
(författare)
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Progress from ASDEX Upgrade experiments in preparing the physics basis of ITER operation and DEMO scenario development
- 2022
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 62:4
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Tidskriftsartikel (refereegranskat)abstract
- An overview of recent results obtained at the tokamak ASDEX Upgrade (AUG) is given. A work flow for predictive profile modelling of AUG discharges was established which is able to reproduce experimental H-mode plasma profiles based on engineering parameters only. In the plasma center, theoretical predictions on plasma current redistribution by a dynamo effect were confirmed experimentally. For core transport, the stabilizing effect of fast ion distributions on turbulent transport is shown to be important to explain the core isotope effect and improves the description of hollow low-Z impurity profiles. The L-H power threshold of hydrogen plasmas is not affected by small helium admixtures and it increases continuously from the deuterium to the hydrogen level when the hydrogen concentration is raised from 0 to 100%. One focus of recent campaigns was the search for a fusion relevant integrated plasma scenario without large edge localised modes (ELMs). Results from six different ELM-free confinement regimes are compared with respect to reactor relevance: ELM suppression by magnetic perturbation coils could be attributed to toroidally asymmetric turbulent fluctuations in the vicinity of the separatrix. Stable improved confinement mode plasma phases with a detached inner divertor were obtained using a feedback control of the plasma β. The enhanced D α H-mode regime was extended to higher heating power by feedback controlled radiative cooling with argon. The quasi-coherent exhaust regime was developed into an integrated scenario at high heating power and energy confinement, with a detached divertor and without large ELMs. Small ELMs close to the separatrix lead to peeling-ballooning stability and quasi continuous power exhaust. Helium beam density fluctuation measurements confirm that transport close to the separatrix is important to achieve the different ELM-free regimes. Based on separatrix plasma parameters and interchange-drift-Alfvén turbulence, an analytic model was derived that reproduces the experimentally found important operational boundaries of the density limit and between L- and H-mode confinement. Feedback control for the X-point radiator (XPR) position was established as an important element for divertor detachment control. Stable and detached ELM-free phases with H-mode confinement quality were obtained when the XPR was moved 10 cm above the X-point. Investigations of the plasma in the future flexible snow-flake divertor of AUG by means of first SOLPS-ITER simulations with drifts activated predict beneficial detachment properties and the activation of an additional strike point by the drifts.
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- Cruz, Raquel, et al.
(författare)
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Novel genes and sex differences in COVID-19 severity
- 2022
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 31:22, s. 3789-3806
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Tidskriftsartikel (refereegranskat)abstract
- Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
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- Dullo, B. T., et al.
(författare)
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LeMMINGs. VI. Connecting nuclear activity to bulge properties of active and inactive galaxies: radio scaling relations and galaxy environment
- 2023
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Ingår i: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 522:3, s. 3412-3438
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Tidskriftsartikel (refereegranskat)abstract
- Multiwavelength studies indicate that nuclear activity and bulge properties are closely related, but the details remain unclear. To study this further, we combine Hubble Space Telescope bulge structural and photometric properties with 1.5 GHz, e-MERLIN nuclear radio continuum data from the LeMMINGs survey for a large sample of 173 'active' galaxies (LINERs and Seyferts) and 'inactive' galaxies (H IIs and absorption line galaxies, ALGs). Dividing our sample into active and inactive, they define distinct (radio core luminosity)-(bulge mass), LR,core − M∗,bulge, relations, with a mass turnover at M∗,bulge ∼ 109.8±0.3M☉ (supermassive blackhole mass MBH ∼ 106.8±0.3M☉), which marks the transition from AGN-dominated nuclear radio emission in more massive bulges to that mainly driven by stellar processes in low-mass bulges. None of our 10/173 bulge-less galaxies host an AGN. The AGN fraction increases with increasing M∗,bulge such that foptical_AGN ∝ M∗,bulge0.24±0.06 and fradio_AGN ∝ M∗,bulge0.24±0.05. Between M∗,bulge ∼ 108.5 and 1011.3M☉, foptical_AGN steadily rises from 15 ± 4 to 80 ± 5 per cent. We find that at fixed bulge mass, the radio loudness, nuclear radio activity, and the (optical and radio) AGN fraction exhibit no dependence on environment. Radio-loud hosts preferentially possess an early-type morphology than radio-quiet hosts, the two types are however indistinguishable in terms of bulge Sérsic index and ellipticity, while results on the bulge inner logarithmic profile slope are inconclusive. We finally discuss the importance of bulge mass in determining the AGN triggering processes, including potential implications for the nuclear radio emission in nearby galaxies.
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- Dullo, B. T., et al.
(författare)
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LeMMINGs: V. Nuclear activity and bulge properties: A detailed multi-component decomposition of e -MERLIN Palomar galaxies with HST
- 2023
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 675
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Tidskriftsartikel (refereegranskat)abstract
- We used high-resolution HST imaging and e-MERLIN 1.5-GHz observations of galaxy cores from the LeMMINGs survey to investigate the relation between optical structural properties and nuclear radio emission for a large sample of galaxies. We performed accurate, multi-component decompositions of new surface brightness profiles extracted from HST images for 163 LeMMINGs galaxies and fitted up to six galaxy components (e.g. bulges, discs, AGN, bars, rings, spiral arms, and nuclear star clusters) simultaneously with Sérsic and/or core-Sérsic models. By adding such decomposition data for ten LeMMINGs galaxies from our past work, the final sample of 173 nearby galaxies (102 Ss, 42 S0s, 23 Es, plus six Irr) with a typical bulge stellar mass of M∗,bulge ~ 106 -1012.5 M⊙ encompasses all optical spectral classes: low-ionisation nuclear emission-line region (LINER), Seyfert, Absorption Line Galaxy (ALG), and H′ ¯II. We show that the bulge mass can be significantly overestimated in many galaxies when components such as bars, rings, and spirals are not included in the fits. We additionally implemented a Monte Carlo method to determine errors on the bulge, disc, and other fitted structural parameters. Moving (in the opposite direction) across the Hubble sequence, that is from the irregular to elliptical galaxies, we confirm that bulges become larger, more prominent, and round. Such bulge dominance is associated with a brighter radio core luminosity. We also find that the radio detection fraction increases with bulge mass. At M∗,bulge ≫ 1011 M⊙, the radio detection fraction is 77%, declining to 24% for M∗,bulge < 1010 M⊙. Furthermore, we observe that core-Sérsic bulges tend to be systematically round and to possess high radio core luminosities and boxy-distorted or pure elliptical isophotes. However, there is no evidence for the previously alleged strong tendency of galaxies'central structures (i.e. a sharp Sérsic, core-Sérsic dichotomy) with their radio loudness, isophote shape, and flattening.
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