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The proliferative h...
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome
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- Duran-Ferrer, Marti (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
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- Clot, Guillem (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
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- Nadeu, Ferran (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
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- Beekman, Renee (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
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- Baumann, Tycho (author)
- CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
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- Nordlund, Jessica (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Marincevic-Zuniga, Yanara (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Lönnerholm, Gudmar, 1941- (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Rivas-Delgado, Alfredo (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
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- Martin, Silvia (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
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- Ordonez, Raquel (author)
- CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDISNA, Ctr Invest Med Aplicada CIMA, Pamplona, Spain.
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- Castellano, Giancarlo (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
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- Kulis, Marta (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
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- Queiros, Ana C. (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
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- Lee, Seung-Tae (author)
- Yonsei Univ, Coll Med, Dept Lab Med, Seoul, South Korea.
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- Wiemels, Joseph (author)
- Univ Southern Calif, Ctr Genet Epidemiol, Los Angeles, CA 90007 USA.
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- Royo, Romina (author)
- Univ Barcelona, Spanish Natl Bioinformat Inst, Inst Recerca Biomed IRB, Programa Conjunto Biol Computac,Barcelona Superco, Barcelona, Spain.
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- Puiggros, Montserrat (author)
- Univ Barcelona, Spanish Natl Bioinformat Inst, Inst Recerca Biomed IRB, Programa Conjunto Biol Computac,Barcelona Superco, Barcelona, Spain.
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- Lu, Junyan (author)
- European Mol Biol Lab EMBL, Heidelberg, Germany.
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- Gine, Eva (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
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- Bea, Silvia (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.
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- Jares, Pedro (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.
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- Agirre, Xabier (author)
- CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDISNA, Ctr Invest Med Aplicada CIMA, Pamplona, Spain.
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- Prosper, Felipe (author)
- CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDISNA, Ctr Invest Med Aplicada CIMA, Pamplona, Spain.;Univ Navarra, Clin Univ Navarra, Hematol & Cell Therapy Dept, Pamplona, Spain.
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- Lopez-Otin, Carlos (author)
- CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Oviedo, Inst Univ Oncol IUOPA, Dept Bioquim & Biol Mol, Oviedo, Spain.
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- Puente, Xose S. (author)
- CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Oviedo, Inst Univ Oncol IUOPA, Dept Bioquim & Biol Mol, Oviedo, Spain.
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- Oakes, Christopher C. (author)
- Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.
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- Zenz, Thorsten (author)
- Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.;Univ Hosp Zurich, Dept Med Oncol & Hematol, Zurich, Switzerland.;Univ Zurich, Zurich, Switzerland.
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- Delgado, Julio (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
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- Lopez-Guillermo, Armando (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
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- Campo, Elias (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Barcelona, Fac Med, Dept Fonaments Clin, Barcelona, Spain.
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- Ignacio Martin-Subero, Jose (author)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Barcelona, Fac Med, Dept Fonaments Clin, Barcelona, Spain.;Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain.
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Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain. CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain. (creator_code:org_t)
- 2020-11-02
- 2020
- English.
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In: NATURE CANCER. - : Springer Nature. - 2662-1347. ; 1:11, s. 1066-1081
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- We report a systematic analysis of the DNA methylation variability in 1,595 samples of normal cell subpopulations and 14 tumor subtypes spanning the entire human B-cell lineage. Differential methylation among tumor entities relates to differences in cellular origin and to de novo epigenetic alterations, which allowed us to build an accurate machine learning-based diagnostic algorithm. We identify extensive individual-specific methylation variability in silenced chromatin associated with the proliferative history of normal and neoplastic B cells. Mitotic activity generally leaves both hyper- and hypomethylation imprints, but some B-cell neoplasms preferentially gain or lose DNA methylation. We construct a DNA-methylation-based mitotic clock, called epiCMIT, whose lapse magnitude represents a strong independent prognostic variable in B-cell tumors and is associated with particular driver genetic alterations. Our findings reveal DNA methylation as a holistic tracer of B-cell tumor developmental history, with implications in differential diagnosis and the prediction of clinical outcome. Martin-Subero and colleagues analyze DNA methylation patterns in B-cell tumors and their normal cells of origin, and develop epiCMIT, a methylation-based mitotic clock with prognostic relevance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Duran-Ferrer, Ma ...
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Clot, Guillem
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Nadeu, Ferran
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Beekman, Renee
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Baumann, Tycho
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Nordlund, Jessic ...
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show more...
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Marincevic-Zunig ...
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Lönnerholm, Gudm ...
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Rivas-Delgado, A ...
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Martin, Silvia
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Ordonez, Raquel
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Castellano, Gian ...
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Kulis, Marta
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Queiros, Ana C.
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Lee, Seung-Tae
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Wiemels, Joseph
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Royo, Romina
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Puiggros, Montse ...
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Lu, Junyan
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Gine, Eva
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Bea, Silvia
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Jares, Pedro
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Agirre, Xabier
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Prosper, Felipe
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Lopez-Otin, Carl ...
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Puente, Xose S.
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Oakes, Christoph ...
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Zenz, Thorsten
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Delgado, Julio
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Lopez-Guillermo, ...
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Campo, Elias
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Ignacio Martin-S ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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NATURE CANCER
- By the university
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Uppsala University