| 1. |
- Becanovic, K, et al.
(författare)
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New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
- 2003
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Ingår i: Journal of Immunology. - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 170:2, s. 1062-1069
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Tidskriftsartikel (refereegranskat)abstract
- Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease in rats that closely mimics many clinical and histopathological aspects of multiple sclerosis. Non-MHC quantitative trait loci regulating myelin oligodendrocyte glycoprotein-induced EAE have previously been identified in the EAE-permissive strain, DA, on rat chromosomes 4,10,15, and 18. To find any additional gene loci in another well-known EAE-permissive strain and thereby to assess any genetic heterogeneity in the regulation of the disease, we have performed a genome-wide linkage analysis in a reciprocal (LEW.1AV1 x PVG.1AV1) male/female F-2 population (n = 185). We examined reciprocal crosses, but no parent-of-origin effect was detected. The parental rat strains share the RT1(av1) MHC haplotype; thus, non-MHC genes control differences in EAE susceptibility. We identified Eae(16) on chromosome 8 and Eae17 on chromosome 13, significantly linked to EAE phenotypes. Two loci, on chromosomes 1 and 17, respectively showed suggestive linkage to clinical and histopathological EAE phenotypes. Eae16 and Eae17 differ from those found in previously studied strain combinations, thus demonstrating genetic heterogeneity of EAE. Furthermore, we detected a locus-specific parent-of-origin effect with suggestive linkage in Eae17. Further genetic and functional dissection of these loci may disclose critical disease-regulating molecular mechanisms.
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| 2. |
- Kritikos, M., et al.
(författare)
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Novel bis(diethylenetriamine)thallium(III) complex. Synthesis and characterization in pyridine solution and in solid
- 2002
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Ingår i: Inorganica Chimica Acta. - 0020-1693 .- 1873-3255. ; 331, s. 224-231
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Tidskriftsartikel (refereegranskat)abstract
- A new complex of thallium(ill) with the nitrogen donor ligand diethylenetriamine (dien) has been prepared and characterized by multinuclear NMR (H-1, C-13. Tl-205), infrared and Raman spectroscopy. and X-ray diffraction. In solution, the symmetric s-facial isomer of [Tl(dien)(2)](3+) is formed. This is a fluxional molecule even at low temperature (235 K): therefore, the different rotamers cannot be observed separately. A complete characterization of the complex is given from its non-trivial NMR spectra. The crystal structure of [Tl(dien)(2)](ClO4)(3).H2O shows u-facial geometry. where the coordination environment around thallium can be described as a distorted trigonal prism.
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| 3. |
- Ma, G. B., et al.
(författare)
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2,2 '-Bipyridinium bis(perchlorate)
- 2000
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Ingår i: Acta Crystallographica Section C. - 0108-2701 .- 1600-5759. ; 56, s. 1473-1475
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Tidskriftsartikel (refereegranskat)abstract
- The title compound, [H(2)bipy](ClO4)(2) or C10H10N22+. 2ClO(4)(-), was obtained at the interface between an organic (2,2'-bipyridine in methanol) and an aqueous phase (perchloric acid in water). The compound crystallizes in space group P(1) over bar and comprises discrete diprotonated trans-bipyridinium cations, [H(2)bipy](2+), and ClO4- anions. The cations and anions are connected through N-H . . .O and C-H . . .O hydrogen bonds [distances N . . .O 2.817 (4) and 2.852 (4) Angstrom, and C . . .O 3.225 (6)-3.412 (5)Angstrom]. The C-C bond distance between the two rings is 1.452 (5) Angstrom. The bipyridinium cation has a trans conformation and the N-C-C-N torsion angle is 152.0 (3)degrees.
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| 4. |
- Ma, G. B., et al.
(författare)
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Equilibrium and structure of thallium(III)-ethylenediamine complexes in pyridine solution and in solid
- 2001
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Ingår i: Inorganica Chimica Acta. - 0020-1693 .- 1873-3255. ; 320:02-jan, s. 92-100
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Tidskriftsartikel (refereegranskat)abstract
- The formation of three [TI(en)(n)](3+) complexes (n = 1-3) in a pyridine solvent has been established by means of Tl-205 and H-1 NMR. Their stepwise stability constants based on concentrations, K-n = [Tl(en)(n)(3+)]/{[Tl(en)(n-1)(3+)](.)[en]}, at 298 K in 0.5 M NaClO4 ionic medium in pyridine, were calculated from Tl-205 NMR integrals: log K-1 = 7.6 +/- 0.7; log K-2 = 5.2 +/- 0.5 and log K-3 = 2.64 +/- 0.05. Linear correlation between both the Tl-205 NMR shifts and spin-spin coupling Tl-205-H-1 versus the stability constants has been found and discussed. A single crystal with the composition [Tl(en)(3)](ClO4)(3) was synthesized and its structure determined by X-ray diffraction. The Tl3+ ion is coordinated by three ethylenediamine ligands via six N-donor atoms in a distorted octahedral fashion.
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| 5. |
- Ma, G. B., et al.
(författare)
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Formation and structure of novel ternary complexes of thallium(III)cyanide-amine (ethylenediamine and triethylenetetramine) in solution and in solid
- 2003
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Ingår i: Inorganica Chimica Acta. - 0020-1693 .- 1873-3255. ; 344, s. 117-122
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Tidskriftsartikel (refereegranskat)abstract
- A novel ternary Tl(III) complex [Tl(en)(2)(CN)](2+) has been synthesized and characterized in solution by NMR and in solid by Raman spectroscopy. This complex has been prepared in the solid state, [Tl(en)(2)(CN)](ClO4)(2) (1), and the related [Tl(tren)(CN)(2)](ClO4) (2), and their crystal structures determined by X-ray diffraction. A linear cyano-bridged supramolecular complex exists in [Tl(en)(2)(CN)](ClO4)(2). In [Tl(tren)(CN)(2)](ClO4), the thallium ion exists in a distorted octahedral geometry cis coordinated cyanides.
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| 6. |
- Ma, G. B., et al.
(författare)
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Novel monomeric phenanthroline-thallium(III) complexes multinuclear NMR characterization in organic solvents
- 2002
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Ingår i: Chinese Chemical Letters. - 1001-8417 .- 1878-5964. ; 13:7, s. 695-698
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Tidskriftsartikel (refereegranskat)abstract
- A novel complex of monomeric thallium(III) with the nitrogen donor ligand phenanthroline (phen) has been prepared and characterized by multinuclear NMR (H-1, C-13, Tl-205). The three complexes exist in equilibria in DMSO and acetonitrile solution which was proved by the Tl-205 NMR spectra. The H-1 and C-13 NMR spectra of tris-phen Tl(III) complex have been measured, where the spin-spin coupling between Tl (I = 1/2) and C-13 or H-1 signals were observed with the H-1 and C-13 NMR spectroscopy in acetonitrile. The coupling constants are presented and the chemical shifts of complexes are discussed in detail.
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| 7. |
- Ma, G. B., et al.
(författare)
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Small platinum-thallium clusters stabilized by ethylenediamine, (NC)(5)Pt-Tl(en)(n-1) (n=1-3) - Characterization in solution and in the solid state
- 2001
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Ingår i: European Journal of Inorganic Chemistry. - 1434-1948 .- 1099-1948. ; :5, s. 1311-1319
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Tidskriftsartikel (refereegranskat)abstract
- Three neutral binuclear platinum-thallium compounds containing a direct and naked (unsupported by ligands) metal-metal bond have been prepared in dimethyl sulfoxide (DMSO). The compounds have the formula [(NC)(5)Pt-Tl(en)(n-1)] (n = 1-3, for compounds 1, 2 and 3, respectively) and were found to exist in solution by means of multinuclear NMR (Pt-195, Tl-205, C-13 and H-1) and Raman spectroscopy. The compounds exhibit very large single bond Pt-195-Tl-205 spin-spin coupling constants of 48-66 kHz. In addition, the solid state analogues of 1 and 3, [(NC)(5)Pt-Tl(DMSO)(4)](DMSO) and [(NC)(5)Pt-Tl(en)(2)]-(DMSO)(2), were synthesized and their structures determined by single crystal X-ray diffraction. The metal-metal bond lengths of Pt-Tl are 2.6131(4) Angstrom and 2.6348(5) Angstrom in compounds I and 3, respectively. Crystal data for compound 1: monoclinic, space group Cc (No. 9), Z = 4, a = 17.2367(14), b = 9.5560(11), c = 17.7941(15) Angstrom, beta = 100.551(10)9 V = 2881.4(5) Angstrom (3), T = 110(1) K; and for compound 3: monoclinic, space group P2(1) (No. 4), Z = 2, a 9.3167(14), b 12.3007(13), c = 11.4586(16) Angstrom, beta = 112.318(16)degrees, V =1214.8(3) Angstrom (3), T = 110(1) K.
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| 8. |
- Ma, G. B., et al.
(författare)
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Structure of the dimethyl sulfoxide solvated thallium(III) ion in solution and in the solid state
- 2001
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Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 40:25, s. 6432-6438
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Tidskriftsartikel (refereegranskat)abstract
- The structure and vibrational spectra of the dimethyl sulfoxide solvated thallium(III) ion have been studied in a dimethyl sulfoxide solution and in the solid state. X-ray crystallography shows a trigonal unit cell, space group R (3) over bar (No. 148), for the [TI(dmso)(6)](ClO4)(3) Compound with Z = 3, a = b = 11.9764(13) [11.8995(9)] Angstrom, c = 20.802(2) [20.467(2)] Angstrom, and V = 2584.0(5) [2509.9(4)] Angstrom (3) at 295 [150] K. The crystal structure comprises a highly symmetric hexakis(dimethyl sulfoxide)thallium(III) ion, with thallium in a 3 symmetry site and a TI-O bond distance of 2.224(3) Angstrom at 295 K. The octahedral TlO6 kernel is compressed along the threefold axis with an O-Tl-O bond angle of 96.20(11)degrees. The Tl-O-S bond angle of 120.7(2)degrees corresponds to a Tl . . .S distance of 3.292(2) Angstrom. One perchlorate ion centered on the (3) over bar axis was described by a statistically disordered model. A low-temperature EXAFS study (10 K) resulted in the TI-O and Tl . . .S distances of 2.221(4) and 3.282(6) Angstrom, respectively, consistent with a Tl-O-S bond angle of 120(1)degrees. The low Debye-Waller factors confirm a regular coordination without the disorder of the dimethyl sulfoxide ligands, which would have resulted from the alternative choice of space group R3 for the crystal structure. Raman and infrared spectra have been recorded and assigned, with the bands at 435 and 447 cm(-1) corresponding to the vibrational frequency of the symmetric and asymmetric TI-O stretching modes, respectively. EXAFS data of a 0.5 mol dm(-3) thallium(III) trifluoromethanesulfonate in a dimethyl sulfoxide solution were consistent with that of a hexasolvated ion with mean Tl-O and Tl . . .S distances of 2.22(1) and 3.33(2) Angstrom, respectively, which correspond to a mean Tl-O-S bond angle of 124(2)degrees. The anomalously large disorder parameter for the TI-O distances is consistent with a weal, pseudo-Jahn-Teller effect. The Tl-205, C-13, and H-1 NMR spectra of the complex in solution show single signals at 1886, 39.5, and 2.3 ppm, respectively.
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| 9. |
- Ma, G. B., et al.
(författare)
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The trigonal-bipyramidal triiodothallium(III) complex TlI3{(CH3)(2)SO}(2)
- 2002
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Ingår i: Acta Crystallographica Section C. - : International Union of Crystallography (IUCr). - 0108-2701 .- 1600-5759. ; 58, s. m177-m178
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Tidskriftsartikel (refereegranskat)abstract
- The title compound, bis(dimethyl sulfoxide)triiodothallium(III), [TlI3 (C2H6OS)(2)], was crystallized from equimolar amounts of (TlI)-I-I and I-2 in a dimethyl sulfoxide (DMSO) solution. After the initial redox reaction, the thallium(III)- iodo complex forms and precipitates as a DMSO solvate. In the crystal structure, Tl is surrounded by three iodide ligands in the equatorial plane and two O-coordinated DMSO molecules in the axial positions, forming a slightly distorted trigonal bipyramid. The complex lies on a twofold rotation axis, making the DMSO molecules and two of the I atoms crystallographically equivalent.
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| 10. |
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