The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes.

Nyckelord

Adenovirus E1A Proteins/*genetics

Blotting; Western

Cell Line

Chromatin/chemistry

DNA-Binding Proteins/*genetics

Exons

Gene Expression Regulation

Humans

Immunoprecipitation

Luciferases/metabolism

Macromolecular Substances

Models; Genetic

Mutagenesis; Site-Directed

Mutation

Phosphoproteins/*genetics

Plasmids/metabolism

Promoter Regions (Genetics)

RNA/*genetics

Research Support; Non-U.S. Gov't

Sp1 Transcription Factor/metabolism

Telomerase/*genetics

Transcription; Genetic

Transfection

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)