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Cerium oxide nanopa...
Cerium oxide nanoparticles inhibit differentiation of neural stem cells
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- Gliga, Anda R. (författare)
- Karolinska Institutet,Karolinska Inst, Div Mol Toxicol, Stockholm, Sweden.;Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Stockholm, Sweden.
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- Edoff, Karin (författare)
- Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
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- Caputo, Fanny (författare)
- Univ Roma Tor Vergata, Dept Biol, Rome, Italy.;Univ Roma Tor Vergata, Dept Chem Sci & Technol, Rome, Italy.
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- Källman, Thomas, 1976- (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Blom, Hans, 1968- (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Royal Inst Technol, Sci Life Lab, Solna, Sweden.
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- Karlsson, Hanna L. (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Stockholm, Sweden.
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- Ghibelli, Lina (författare)
- Univ Roma Tor Vergata, Dept Biol, Rome, Italy.
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- Traversa, Enrico (författare)
- Univ Roma Tor Vergata, Dept Chem Sci & Technol, Rome, Italy.;Xi An Jiao Tong Univ, Int Res Ctr Renewable Energy, Xian, Shaanxi, Peoples R China.
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- Ceccatelli, Sandra (författare)
- Karolinska Institutet,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
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- Fadeel, Bengt (författare)
- Karolinska Institutet,Karolinska Inst, Div Mol Toxicol, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Div Mol Toxicol, Stockholm, Sweden;Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Stockholm, Sweden. (creator_code:org_t)
- 2017-08-24
- 2017
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 7
- Relaterad länk:
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https://www.nature.c...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Cerium oxide nanoparticles (nanoceria) display antioxidant properties and have shown cytoprotective effects both in vitro and in vivo. Here, we explored the effects of nanoceria on neural progenitor cells using the C17.2 murine cell line as a model. First, we assessed the effects of nanoceria versus samarium (Sm) doped nanoceria on cell viability in the presence of the prooxidant, DMNQ. Both particles were taken up by cells and nanoceria, but not Sm-doped nanoceria, elicited a temporary cytoprotective effect upon exposure to DMNQ. Next, we employed RNA sequencing to explore the transcriptional responses induced by nanoceria or Sm-doped nanoceria during neuronal differentiation. Detailed computational analyses showed that nanoceria altered pathways and networks relevant for neuronal development, leading us to hypothesize that nanoceria inhibits neuronal differentiation, and that nanoceria and Sm-doped nanoceria both interfere with cytoskeletal organization. We confirmed that nanoceria reduced neuron specific beta 3-tubulin expression, a marker of neuronal differentiation, and GFAP, a neuroglial marker. Furthermore, using super-resolution microscopy approaches, we could show that both particles interfered with cytoskeletal organization and altered the structure of neural growth cones. Taken together, these results reveal that nanoceria may impact on neuronal differentiation, suggesting that nanoceria could pose a developmental neurotoxicity hazard.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- art (ämneskategori)
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Gliga, Anda R.
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Edoff, Karin
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Caputo, Fanny
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Källman, Thomas, ...
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Blom, Hans, 1968 ...
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Karlsson, Hanna ...
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visa fler...
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Ghibelli, Lina
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Traversa, Enrico
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Ceccatelli, Sand ...
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Fadeel, Bengt
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visa färre...
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Kungliga Tekniska Högskolan
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Karolinska Institutet
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Uppsala universitet