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Predictors of histo...
Predictors of histology, tissue eosinophilia and mast cell infiltration in Hodgkin's Lymphoma : a population-based study
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- Glimelius, Ingrid, 1975- (författare)
- Uppsala universitet,Enheten för onkologi
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- Rubin, Jenny (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Rostgaard, Klaus (författare)
- Department of Epidemiology Research, Statens Serum Institut, Denmark
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- Amini, Rose Marie (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Simonsson, Martin (författare)
- Uppsala universitet,Enheten för onkologi
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- Sorensen, Karina Meden (författare)
- Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Denmark
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- Ekström-Smedby, Karin (författare)
- Karolinska Institutet
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- Venge, Per (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Hjalgrim, Henrik (författare)
- Department of Epidemiology Research, Statens Serum Institut, Denmark
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- Molin, Daniel (författare)
- Uppsala universitet,Enheten för onkologi
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- Enblad, Gunilla (författare)
- Uppsala universitet,Enheten för onkologi
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(creator_code:org_t)
- 2011-07-26
- 2011
- Engelska.
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Ingår i: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 87:3, s. 208-216
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Classical Hodgkin’s lymphoma (HL) lesions comprise few tumour cells, surrounded by numerous inflammatory cells. Like in other malignancies, the microenvironment is presumed to be clinically important in HL; however, microenvironment predictors remain poorly characterised. The aim of this study was to investigate how selected patient characteristics and genetic factors affect HL phenotype, in particular tissue eosinophilia, mast cell counts and HL histological subtype.Methods: In a population-based study, patients with HL were interviewed about potential HL risk factors. Available tumours, n = 448, were classified histologically; the number of eosinophils and mast cells were estimated, and eosinophil cationic protein (ECP) and eosinophil protein-x (EPX) gene polymorphisms were determined. Associations were assessed in regression models.Results: Self-reported history of asthma was predictive of having tumour eosinophilia [≥200 eosinophils/10 high power fields, univariate odds ratio (OR) = 2.22, 95% CI 1.06–4.64, P = 0.03]. High numbers of eosinophils were predominantly seen in patients carrying the genotype ECP434GG [multivariate relative levels (RLs) = 1.84, 95% CI 1.02–3.30, P = 0.04]. Lower number of eosinophils was seen in Epstein–Barr virus (EBV)-positive tumours (univariate RL = 0.52, 95% CI 0.3–0.9, P = 0.02) and in older patients (univariate RL = 0.85, 95% CI 0.73–0.99, P = 0.03). Well-known factors such as young age, female sex and EBV-negative status predicted nodular sclerosis histology.Conclusion: The number of eosinophils in HL tumours is influenced by patient traits such as asthma, ECP genotype and EBV status. EBV status was predictive of histology.
Nyckelord
- Hodgkin lymphoma
- microenvironment
- eosinophils
- mast cells
- asthma
- ECP
- hives
- histology
- MEDICINE
- MEDICIN
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- art (ämneskategori)
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Glimelius, Ingri ...
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Rubin, Jenny
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Rostgaard, Klaus
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Amini, Rose Mari ...
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Simonsson, Marti ...
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Sorensen, Karina ...
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visa fler...
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Ekström-Smedby, ...
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Venge, Per
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Hjalgrim, Henrik
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Molin, Daniel
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Enblad, Gunilla
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European Journal ...
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Uppsala universitet
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Karolinska Institutet