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Interplay between C...
Interplay between Caveolin-1 and body and tumor size affects clinical outcomes in breast cancer
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- Godina, Christopher (author)
- Lund University,Lunds universitet,Lund Univ, Dept Clin Sci Lund, Div Oncol, Barngatan 4, SE-22185 Lund, Sweden.;Skane Univ Hosp, Barngatan 4, SE-22185 Lund, Sweden.,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cancerepidemiologi & strål,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Cancerepidemiology and radiation,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Indira Chandran, Vineesh (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Barbachowska, Magdalena (author)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,Skåne University Hospital
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- Tryggvadottir, Helga (author)
- Lund University,Lunds universitet,Epidemiologi och farmakogenetik,Forskargrupper vid Lunds universitet,Epidemiology and pharmacogenetics,Lund University Research Groups,Skåne University Hospital
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- Nodin, Björn (author)
- Lund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Skåne University Hospital
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- Visse, Edward (author)
- Lund University,Lunds universitet,Glioma immunterapigrupp,Forskargrupper vid Lunds universitet,Glioma immunotherapy group,Lund University Research Groups,Skåne University Hospital
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- Borgquist, Signe (author)
- Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,Breast cancer prevention & intervention,Lund University Research Groups,Aarhus University,Aarhus University Hospital,Skåne University Hospital
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Isaksson, Karolin (author)
- Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Lund Melanoma Study Group,Lund University Research Groups,Central Hospital Kristianstad
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- Bosch, Ana (author)
- Lund University,Lunds universitet,Molekylära behandlingsstrategier vid bröstcancer,Forskargrupper vid Lunds universitet,Molecular therapeutics in breast cancer,Lund University Research Groups,Skåne University Hospital
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- Belting, Mattias (author)
- Uppsala University,Lund University,Lunds universitet,Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab,Lund Univ, Dept Clin Sci Lund, Div Oncol, Barngatan 4, SE-22185 Lund, Sweden.;Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Malmö, Sweden.;Skane Univ Hosp, Barngatan 4, SE-22185 Lund, Sweden.,Tumörmikromiljön,Forskargrupper vid Lunds universitet,Tumor microenvironment,Lund University Research Groups,Skåne University Hospital
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- Jernström, Helena (author)
- Lund University,Lunds universitet,Epidemiologi och farmakogenetik,Forskargrupper vid Lunds universitet,Epidemiology and pharmacogenetics,Lund University Research Groups,Skåne University Hospital
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Lund Univ, Dept Clin Sci Lund, Div Oncol, Barngatan 4, SE-22185 Lund, Sweden;Skane Univ Hosp, Barngatan 4, SE-22185 Lund, Sweden. LUCC: Lunds universitets cancercentrum (creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Translational Oncology. - : Elsevier. - 1944-7124 .- 1936-5233. ; 22
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Abstract
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- Background: Caveolin-1 (CAV1) is associated with cholesterol-rich membrane raft domains and is a master regulator of cell signaling and membrane transport. Here, we investigated CAV1's role in cellular compartments of breast cancer in relation to signaling pathways, clinicopathological features, and clinical outcomes.Methods: CAV1 levels were evaluated with immunohistochemistry in cytoplasm of invasive tumor cells and stromal cells in tumor tissue microarrays from a cohort of 1018 breast cancer patients (inclusion 2002-2012, Sweden). Cytoplasmic and stromal CAV1 were categorized as positive/negative and strong/not strong, respectively. CAV1 expression in relation to clinical outcomes was assessed with Cox regression. Investigations into CAV1 functional pathways was conducted in the STRING, GOBO, and TCGA databases.Results: CAV1 expression was associated with non-luminal subtypes, cell cycle control, inflammation, epithelialmesenchymal transition, and the IGF/Insulin system. Generally, CAV1 was not associated with recurrence risk. Stromal CAV1's impact on recurrence risk was modified by BMI > 25 kg/m(2) (P-interaction = 0.002), waist > 80 cm (P-interaction = 0.005), and invasive tumor size (pT2/3/4) (P-interaction = 0.028). In low-risk patients only, strong stromal CAV1 significantly increased recurrence risk (HRs(adj) > 1.61). In all patients, positive cytoplasmic CAV1 conferred > 2-fold risk for contralateral disease HRadj 2.63 (95% CI 1.36-5.10). Strong stromal CAV1 conferred nearly 2-fold risk for locoregional recurrence HRadj 1.88 (95% CI 1.09-3.24).Conclusions: CAV1's prognostic impact depended on its localization, anthropometric, and tumor factors. Stromal CAV1 predicted high recurrence risk in a group of supposedly "low-risk' patients. Cytoplasmic CAV1 predicted metachronous contralateral disease. If confirmed, CAV1 could be used as treatment target and for risk stratification.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Breast cancer
- Caveolin-1
- Anthropometrics
- Cohort
- Prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Godina, Christop ...
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Indira Chandran, ...
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Barbachowska, Ma ...
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Tryggvadottir, H ...
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Nodin, Björn
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Visse, Edward
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Borgquist, Signe
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Jirström, Karin
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Isaksson, Karoli ...
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Bosch, Ana
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Belting, Mattias
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Jernström, Helen ...
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