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Validation of stand...
Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children
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- Björk, Jonas (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Nyman, Ulf (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups
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- Berg, Ulla (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Delanaye, Pierre (författare)
- University of Liège
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- Dubourg, Laurence (författare)
- Hôpital Edouard Herriot,Claude Bernard University Lyon 1
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- Goffin, Karolien (författare)
- University Hospitals Leuven
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- Grubb, Anders (författare)
- Lund University,Lunds universitet,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups,Skåne University Hospital
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- Hansson, Magnus (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Littmann, Karin (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Åsling-Monemi, Kajsa (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Bökenkamp, Arend (författare)
- Vrije Universiteit Amsterdam,Emma Children’s Hospital
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- Pottel, Hans (författare)
- Catholic University of Leuven
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(creator_code:org_t)
- 2019-02-04
- 2019
- Engelska.
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Ingår i: Pediatric Nephrology. - : Springer Science and Business Media LLC. - 0931-041X .- 1432-198X.
- Relaterad länk:
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http://dx.doi.org/10...
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https://orbi.uliege....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from several European medical centres. Methods: Three thousand four hundred eight measurements of GFR (mGFR) using plasma clearance of exogenous substances were performed in 2218 children aged 2–17 years. Validated equations included Schwartz-2009CR/2012CR/CYS/CR+CYS, FASCR/CYS/CR+CYS, LMRCR, Schwartz-LyonCR, BergCYS, CAPACYS, CKD-EPICYS, AndersenCR+CYS and arithmetic means of the best single-marker equations in explorative analysis. Five metrics were used to compare the performance of the GFR equations: bias, precision and three accuracy measures including the percentage of GFR estimates (eGFR) within ± 10% (P10) and ± 30% (P30) of mGFR. Results: Three of the cystatin C equations, BergCYS, CAPACYS and CKD-EPICYS, exhibited low bias and generally satisfactory accuracy across all levels of mGFR; CKD-EPICYS had more stable performance across gender than the two other equations. Among creatinine equations, Schwartz-LyonCR had the best performance but was inaccurate at mGFR < 30 mL/min/1.73 m2 and in underweight patients. Arithmetic means of the best creatinine and cystatin C equations above improved bias compared to the existing composite creatinine+cystatin C equations. Conclusions: The present study strongly suggests that cystatin C should be the primary biomarker of choice when estimating GFR in children with decreased GFR. Arithmetic means of well-performing single-marker equations improve accuracy further at most mGFR levels and have practical advantages compared to composite equations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Children
- Chronic kidney disease
- Glomerular filtration rate
- Kidney function tests
- Renal failure
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- art (ämneskategori)
- ref (ämneskategori)
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Björk, Jonas
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Nyman, Ulf
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Berg, Ulla
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Delanaye, Pierre
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Dubourg, Laurenc ...
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Goffin, Karolien
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visa fler...
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Grubb, Anders
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Hansson, Magnus
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Littmann, Karin
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Åsling-Monemi, K ...
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Bökenkamp, Arend
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Pottel, Hans
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Pediatrik
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Pediatric Nephro ...
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Lunds universitet
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Karolinska Institutet