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- Fazey, Ioan, et al.
(författare)
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Ten essentials for action-oriented and second order energy transitions, transformations and climate change research
- 2018
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Ingår i: Energy Research and Social Science. - : Elsevier BV. - 2214-6296 .- 2214-6326. ; 40, s. 54-70
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Forskningsöversikt (refereegranskat)abstract
- The most critical question for climate research is no longer about the problem, but about how to facilitate the transformative changes necessary to avoid catastrophic climate-induced change. Addressing this question, however, will require massive upscaling of research that can rapidly enhance learning about transformations. Ten essentials for guiding action-oriented transformation and energy research are therefore presented, framed in relation to second-order science. They include: (1) Focus on transformations to low-carbon, resilient living; (2) Focus on solution processes; (3) Focus on ‘how to’ practical knowledge; (4) Approach research as occurring from within the system being intervened; (5) Work with normative aspects; (6) Seek to transcend current thinking; (7) Take a multi-faceted approach to understand and shape change; (8) Acknowledge the value of alternative roles of researchers; (9) Encourage second-order experimentation; and (10) Be reflexive. Joint application of the essentials would create highly adaptive, reflexive, collaborative and impact-oriented research able to enhance capacity to respond to the climate challenge. At present, however, the practice of such approaches is limited and constrained by dominance of other approaches. For wider transformations to low carbon living and energy systems to occur, transformations will therefore also be needed in the way in which knowledge is produced and used.
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| 2. |
- Hajra, Rajkumar, et al.
(författare)
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Cometary plasma response to interplanetary corotating interaction regions during 2016 June-September : a quantitative study by the Rosetta Plasma Consortium
- 2018
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 480:4, s. 4544-4556
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Tidskriftsartikel (refereegranskat)abstract
- Four interplanetary corotating interaction regions (CIRs) were identified during 2016 June-September by the Rosetta Plasma Consortium (RPC) monitoring in situ the plasma environment of the comet 67P/Churyumov-Gerasimenko (67P) at heliocentric distances of similar to 3-3.8 au. The CIRs, formed in the interface region between low- and high-speed solar wind streams with speeds of similar to 320-400 km s(-1) and similar to 580-640 km s(-1), respectively, are characterized by relative increases in solar wind proton density by factors of similar to 13-29, in proton temperature by similar to 7-29, and in magnetic field by similar to 1-4 with respect to the pre-CIR values. The CIR boundaries are well defined with interplanetary discontinuities. Out of 10 discontinuities, four are determined to be forward waves and five are reverse waves, propagating at similar to 5-92 per cent of the magnetosonic speed at angles of similar to 20 degrees-87 degrees relative to ambient magnetic field. Only one is identified to be a quasi-parallel forward shock with magnetosonic Mach number of similar to 1.48 and shock normal angle of similar to 41 degrees. The cometary ionosphere response was monitored by Rosetta from cometocentric distances of similar to 4-30 km. A quiet time plasma density map was developed by considering dependences on cometary latitude, longitude, and cometocentric distance of Rosetta observations before and after each of the CIR intervals. The CIRs lead to plasma density enhancements of similar to 500-1000 per cent with respect to the quiet time reference level. Ionospheric modelling shows that increased ionization rate due to enhanced ionizing (>12-200 eV) electron impact is the prime cause of the large cometary plasma density enhancements during the CIRs. Plausible origin mechanisms of the cometary ionizing electron enhancements are discussed.
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| 3. |
- Sampson, Joshua N., et al.
(författare)
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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
- 2015
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 107:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
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