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- Lechman, Eric R, et al.
(författare)
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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.
- 2016
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Ingår i: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 29:2, s. 214-228
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Tidskriftsartikel (refereegranskat)abstract
- To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from functionally validated subpopulations of AML samples. For one signature miRNA, miR-126, high bioactivity aggregated all in vivo patient sample LSC activity into a single sorted population, tightly coupling miR-126 expression to LSC function. Through functional studies, miR-126 was found to restrain cell cycle progression, prevent differentiation, and increase self-renewal of primary LSC in vivo. Compared with prior results showing miR-126 regulation of normal hematopoietic stem cell (HSC) cycling, these functional stem effects are opposite between LSC and HSC. Combined transcriptome and proteome analysis demonstrates that miR-126 targets the PI3K/AKT/MTOR signaling pathway, preserving LSC quiescence and promoting chemotherapy resistance.
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- Golub, M.V., et al.
(författare)
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Effective spring boundary conditions for a damaged interface between dissimilar media in three-dimensional case
- 2016
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Ingår i: International Journal of Solids and Structures. - : Elsevier BV. - 0020-7683. ; 81, s. 141-150
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Tidskriftsartikel (refereegranskat)abstract
- Elastic waves in the presence of a damaged interface between two dissimilar elastic media is investigated in the three-dimensional case. The damaged is modeled as a stochastic distribution of equally sized circular cracks which is transformed into a spring boundary condition. First the scattering by a single circular interface crack between two dissimilar half-spaces is investigated and solved explicitly for normally incident waves in the low frequency limit. The transmission by a distribution of cracks is then determined and is transformed into a spring boundary condition, where effective spring stiffnesses are expressed in terms of elastic moduli and damage parameters. A comparison with previous results for a periodic distribution of cracks shows good agreement.
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- Golub, M. V., et al.
(författare)
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TRANSMISSION OF ELASTIC WAVES THROUGH AN INTERFACE BETWEEN DISSIMILAR MEDIA WITH RANDOM AND PERIODIC DISTRIBUTIONS OF STRIP-LIKE MICRO-CRACKS
- 2018
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Ingår i: Materials Physics and Mechanics. - 1605-8119 .- 1605-2730. ; 37:1, s. 52-59
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Tidskriftsartikel (refereegranskat)abstract
- The present work investigates wave propagation through a damaged interface between two elastic media. Dynamic behaviour of the deterioration or damage of an interface is described using a random distribution of strip-like micro-cracks of different sizes, a periodic array of strip-like cracks or via a distributed spring model. The wave-field scattered by cracks is calculated using a boundary integral equation method. The spring model assumes introduction of the spring boundary conditions, where stresses are proportional to the displacement jump with the proportionality given by the spring stiffness. Components of the spring stiffness matrix are defined in terms of the concentration of the defects, their typical size and the elastic properties of the contacting materials. Numerical analysis of reflection and transmission for the considered models of the damaged interface is provided.
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- Kravets, A. F., et al.
(författare)
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Anisotropic magnetization relaxation in ferromagnetic multilayers with variable interlayer exchange coupling
- 2016
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Ingår i: PHYSICAL REVIEW B. - : American Physical Society. - 2469-9950. ; 94:6
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Tidskriftsartikel (refereegranskat)abstract
- The ferromagnetic resonance (FMR) linewidth and its anisotropy in F-1/f/F-2/AF multilayers, where spacer f has a low Curie point compared to the strongly ferromagnetic F-1 and F-2, is investigated. The role of the interlayer exchange coupling in magnetization relaxation is determined experimentally by varying the thickness of the spacer. It is shown that stronger interlayer coupling via thinner spacers enhances the microwave energy exchange between the outer ferromagnetic layers, with themagnetization of F-2 exchange dragged by the resonance precession in F-1. A weaker mirror effect is also observed: the magnetization of F-1 can be exchange dragged by the precession in F-2, which leads to antidamping and narrower FMR linewidths. A theory is developed to model the measured data, which allows separating various contributions to the magnetic relaxation in the system. Key physical parameters, such as the interlayer coupling constant, in-plane anisotropy of the FMR linewidth, and dispersion of the magnetic anisotropy fields, are quantified. These results should be useful for designing high-speed magnetic nanodevices based on thermally assisted switching.
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