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Sökning: WFRF:(Gomes M.) > (2000-2004)

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  • Estalote, AC, et al. (författare)
  • A novel blood group B subgroup: serological and genetic studies
  • 2004
  • Ingår i: Transfusion Medicine. - : Wiley. - 0958-7578 .- 1365-3148. ; 14:2, s. 173-180
  • Tidskriftsartikel (refereegranskat)abstract
    • A discrepancy in the ABO blood groups between a newborn child and her parents was identified. Serological and DNA investigative techniques were performed. A weak variant of B (B-w) was detected on the erythrocytes of the child, her grandmother and great-uncle. Adsorption-elution studies showed that their erythrocytes adsorb and yield anti-B on elution. The B-w antigenic strength of the A(1)B(w) cells of her mother and maternal aunt was reduced when compared to that of the A(2)B(w) from another family member. Only one of 15 different anti-B sera agglutinated the A(1)B(w) erythrocytes. Agglutinin anti-B that reacted strongly with normal B erythrocytes and did not agglutinate the B-w cells, was found in the sera of the A(1)B(w) individuals. The B-w serum glycosyltransferase could not convert O cells into B cells and no B substance was found in saliva. All family members with the B-w/AB(w) phenotypes were heterozygous for a B allele and DNA sequencing revealed a novel missense mutation in exon 7 of the B allele (556A > G), resulting in M186V. This substitution changes a highly conserved region of the enzyme, proposed to be a disordered loop near the enzyme cleft, and is expected to diminish the enzyme's activity, leading to this B-w phenotype.
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  • Gomes, Sônia M., et al. (författare)
  • Combining Wavelets with Finite Differences : Consistency Analysis
  • 2002
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • The method is an adaptive finite difference strategy for numerical solution of evolution partial differential equations. The principle is to represent the solution only through those point values indicated by the significant wavelet coefficients. Typically, few points are found in each time step, the grid being coarse in smooth regions, and refined close to irregularities. At each point, the spatial derivatives are discretized by uniform finite differences, using step size proportional to the point local scale. Eventually, required neighboring stencils are not present in the grid. In such case, the correspondig point values are approximated from coarser scales by using reconstruction operators defined by means of interpolating subdivision scheme. Our purpose in this paper is to analyse a generalization of the concept of truncation error, which is the familiar basis of the analysis of difference schemes. For this consistency analysis, we show that the adaptive finite difference scheme can also be formulated in terms of a collocation scheme for an adapted wavelet expansion of the solution. For this purpose, we first prove some results concerning the local behavior of the reconstruction operators, which stand for appropiate cone-like grids.
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  • Resultat 1-10 av 23

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