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- Schael, S, et al.
(författare)
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Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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| 2. |
- Gonzalez Palmén, Lorena, 1970-
(författare)
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Homotrimeric dUTPases : Principles of Catalysis and Inhibitor Design
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The ubiquitous enzyme dUTPase hydrolyzes dUTP into dUMP and pyrophosphate, preventing DNA fragmentation and cell death due to accumulation of dUTP. Inhibitors of dUTPase could serve as drugs in the treatment of cancers and infectious diseases. This thesis presents five studies. A mutational study on the Escherichia coli dUTPase (S72A) provides new insights about the catalytic principles of the homotrimeric dUTPases. A model is presented in which transition state formation is associated with a rotation of the conserved Ser72 side chain. The model can explain the strict order of deamination and hydrolysis catalyzed by the bifunctional dCTP deaminase:dUTPases. The S72A/D90N double mutant is currently investigated. Preliminary data indicate that this form preserves the binding properties of the S72A mutant but is completely inactive, making it attractive for structural studies. In the remaining studies we compare the binding of substrate analogues to the human, the E. coli and the equine infectious anemia virus (EIAV) homotrimeric dUTPases. One study concerns 2´,3´-dideoxy-UTP (ddUTP) and shows that removal of the 3´-hydroxyl group increases KM, ten times with the cellular dUTPases and fifty times with the viral dUTPase, but does not affect kcat with any of these enzymes. Another study concerns the inhibitory effects of 3´-azido-2´,3´-dideoxy-UTP. This derivative binds to the bacterial dUTPase but not to the other forms making it a potential lead for the development of antibacterial dUTPase inhibitors. Yet another study investigates two uracil derivatives. Both compounds are found to inhibit the human, the bacterial but not the viral dUTPase. The inhibition is shown to be competitive.
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- Rodríguez de Llera González, Delia, 1978-
(författare)
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Methodologies and Tools for the Design and Optimization of Multi-Standard Radio Receivers
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- One of the main challenges posed by 4G wireless communication systems is achieving flexible, programmable multi-standard radio transceivers with maximum hardware share amongst different standards at a minimum power consumption. Evaluating the feasibility and performance of different multi-standard/multi-band radio solutions at an early stage, i.e. system level, is key for succeeding in surmounting this challenge. This entails for- mulation of the transceiver budget for several RF architectures and frequency plans with different degrees of hardware sharing. This task is complicated by the fact that transceiver blocks can have different implementations that lead to different performances. The tools that are available for use at present have only analysis capabilities or address only one standard and/or receiver architecture at a time.In the belief that a new approach to this problem is necessary, the work that has led to this thesis proposes a novel methodology that automates the design-space explo- ration of integrated multi-standard wireless radio receivers. This methodology has been implemented in a multi-standard RF Transceiver Architecture Comparison Tool, TACT. TACT helps surmounting many of the challenges faced by RF system designers targeting multi-standard/multi-band radio receivers.The goal of the algorithms TACT is built upon is to find a multi-standard receiver frequency plan and budget that meets or exceeds the specifications of the addressed wire- less standards while keeping the requirements of each of the receiver blocks as relaxed as possible. TACT offers RF engineers a deep insight into the receiver behavior at a very early stage of the design flow. It models the impact of critical circuit non-idealities using a high level of abstraction. This reduces the number of design iterations and, thus, the time-to-market of the solution. The reuse of already available intellectual property (IP) blocks is also considered in TACT, what can result in a significant cost reduction of the receiver implementation. A combination of a behavioural-based cooperative multi-agent optimization and deterministic techniques is proposed.The capabilities of the proposed techniques and developed tool are illustrated through case studies addressing different design challenges the design of multi-standard receivers present.The last part of this thesis is devoted to one of the key blocks of any communica- tions receiver: the analog-to-digital converter. This work focuses on modeling and design methodologies for continuous-time ΔΣ modulators. A method to evaluate the stability margin of continuous-time ΔΣ modulators as a function of the timing uncertainty effects is proposed.
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